2009
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten AF. Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience 2009, 10: 410-422. PMID: 19455173, PMCID: PMC2907136, DOI: 10.1038/nrn2648.Peer-Reviewed Original ResearchConceptsPrefrontal functionMemory abilityUncontrollable stressPrefrontal cortex structurePrefrontal pyramidal cellsControl of behaviorCognitive abilitiesEmotional operationsPrefrontal networkImpair performanceMental illnessPrefrontal dysfunctionPrefrontal cortexPrefrontal gray matterPrefrontal neuronsMemory functionStress impairsPersistent firingNeurochemical environmentStress exposureNeurochemical eventsCortex structureHigh levelsEmotionsChronic stress
2000
Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine α-1 receptor mechanisms
Arnsten A. Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine α-1 receptor mechanisms. Progress In Brain Research 2000, 126: 183-192. PMID: 11105647, DOI: 10.1016/s0079-6123(00)26014-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmygdalaAnimalsAttentionCalcium SignalingCyclic AMPCyclic AMP-Dependent Protein KinasesDopamineHaplorhiniHelplessness, LearnedHumansMemory DisordersModels, NeurologicalModels, PsychologicalNerve Tissue ProteinsNoiseNorepinephrinePhosphatidylinositol Diacylglycerol-LyasePrefrontal CortexRatsReceptors, Adrenergic, alpha-1Receptors, Dopamine D1Second Messenger SystemsStress, PhysiologicalType C PhospholipasesConceptsMemory functionSensory cortexLong-term memory consolidationLong-term memoryPrefrontal cortical functionAssociative memory functionStress-induced deficitsAttentional regulationFocus of attentionAversive eventsMemory consolidationSalient signalsCortical functionProminent stimulusNorepinephrine αHigh levelsAmygdalaCortexCatecholamine releaseAttentionMemoryStimuliDeficitsΒ-receptor stimulationD1 receptors
1999
α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function
Arnsten A, Mathew R, Ubriani R, Taylor J, Li B. α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biological Psychiatry 1999, 45: 26-31. PMID: 9894572, DOI: 10.1016/s0006-3223(98)00296-0.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCognitive functionPrefrontal cortical cognitive functionCortical cognitive functionsImpairs cognitive functionHigher cortical functionsMemory taskAlpha-1 adrenoceptorsMost antipsychotic medicationsAlternation performanceNoradrenergic turnoverCortical functionPhenylephrine responseAlpha-1 adrenoceptor stimulationNeuropsychiatric disordersAlpha-1 adrenergic antagonistAlpha-1 adrenergic agonistDisordersAntipsychotic medicationAnxietyHigh levelsPhenylephrine infusionAdrenoceptor stimulationAdrenergic antagonistsSecond messenger pathways
1998
Catecholamine modulation of prefrontal cortical cognitive function
Arnsten A. Catecholamine modulation of prefrontal cortical cognitive function. Trends In Cognitive Sciences 1998, 2: 436-447. PMID: 21227275, DOI: 10.1016/s1364-6613(98)01240-6.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPrefrontal cortexCognitive functionPrefrontal cortical cognitive functionUncontrollable stressCortical cognitive functionsWorking Memory FunctionDeficit hyperactivity disorderHyperactivity disorderPFC functionPFC dysfunctionNormal agingCognitive disordersCatecholamine modulationDopamine systemNeurochemical influencesMental disordersNeuropsychiatric disordersDisordersEnvironmental cuesCuesNeuromodulatory inputsMemoryFresh understandingHigh levels