2002
Actions of α-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype
Franowicz JS, Arnsten A. Actions of α-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype. Psychopharmacology 2002, 162: 304-312. PMID: 12122489, DOI: 10.1007/s00213-002-1110-6.Peer-Reviewed Original ResearchConceptsSame receptor subtypeReceptor subtypesBlood pressureCognitive improvementHypotensive effectNoradrenergic agonistsRhesus monkeysDose-dependent reversalCognitive-enhancing effectsNon-human primatesIdazoxan doseCognitive enhancementMK-912Same dosesHypotensionLow dosesAgonistsSubtypesPotent antagonistAntagonistMK912Recent evidenceClonidineIdazoxanDoses
1985
Stress produces opioid-like effects on investigatory behavior
Arnsten A, Berridge C, Segal DS. Stress produces opioid-like effects on investigatory behavior. Pharmacology Biochemistry And Behavior 1985, 22: 803-809. PMID: 4011639, DOI: 10.1016/0091-3057(85)90531-3.Peer-Reviewed Original ResearchConceptsOpioid systemInvestigatory behaviorOpiate antagonist naloxoneOpioid-like effectsAntagonist naloxoneStress-induced reductionLocomotor hypoactivityOpiate agonistsNaive ratsLow dosesCharacteristic alterationsGreater reductionAverage timeNovel environmentRatsNumerous reportsBehavioral activityAlterationsExposureNaloxoneStressorsAgonistsHypoactivityDoses