2013
Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction
Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF. Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Translational Psychiatry 2013, 3: e328-e328. PMID: 24301646, PMCID: PMC4030323, DOI: 10.1038/tp.2013.104.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCyclic adenosine monophosphateMental illnessRestraint stressCognitive dysfunctionControl groupStress-induced cognitive dysfunctionPhosphodiesterase 4Schizophrenia 1Prefrontal cognitive dysfunctionMild restraint stressH restraint stressUnoperated control groupKD ratsDISC1 mutationViral knockdownNormal animalsPFC dysfunctionImpair functionIncreases SusceptibilityDysfunctionDISC1 geneIllnessCAMP levelsMultifunctional scaffolding protein
2006
Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2000
Local synaptic connections of basal forebrain neurons
Zaborszky L, Duque A. Local synaptic connections of basal forebrain neurons. Behavioural Brain Research 2000, 115: 143-158. PMID: 11000417, DOI: 10.1016/s0166-4328(00)00255-2.Peer-Reviewed Original ResearchConceptsBasal forebrainLocal collateralsLocal synaptic connectionsBasal forebrain neuronsBasal forebrain regionsCholinergic neuronsElectron microscopic levelProjection neuronsCortical plasticityForebrain neuronsFrontal cortexForebrain regionsPutative interneuronsAxon arborsSynaptic connectionsNeural circuitryNeuronsForebrainInterneuronsIntegrative processingCollateralsNPYSomatostatinBiocytinCortex