2011
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
Elashoff MR, Wingrove JA, Beineke P, Daniels SE, Tingley WG, Rosenberg S, Voros S, Kraus WE, Ginsburg GS, Schwartz RS, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky AJ, Topol EJ. Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients. BMC Medical Genomics 2011, 4: 26. PMID: 21443790, PMCID: PMC3072303, DOI: 10.1186/1755-8794-4-26.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlgorithmsBlood CellsCase-Control StudiesCluster AnalysisCohort StudiesCoronary Artery DiseaseDiabetes MellitusFemaleGene Expression RegulationHumansMaleMicroarray AnalysisMiddle AgedReverse Transcriptase Polymerase Chain ReactionROC CurveSex FactorsConceptsObstructive coronary artery diseaseCoronary artery diseaseNon-diabetic patientsDiabetic statusArtery diseaseRT-PCR analysisNon-invasive blood testStudy of patientsPeripheral blood cellsClassifier genesCell type-specific markersPREDICT cohortGene expressionClinical factorsInvasive angiographyBlood testsControl cohortRegistry casesCohort analysisPREDICT studyResultsMicroarray analysisDiagnostic utilityPopulation predictorsRT-PCR dataCAD association
2010
Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.
Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky A, Winn ME, Schork NJ, Topol EJ. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Annals Of Internal Medicine 2010, 153: 425-34. PMID: 20921541, PMCID: PMC3786733, DOI: 10.7326/0003-4819-153-7-201010050-00005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAlgorithmsArea Under CurveChest PainCoronary AngiographyCoronary Artery DiseaseDiabetes MellitusFemaleGene ExpressionHumansMaleMiddle AgedProspective StudiesReverse Transcriptase Polymerase Chain ReactionRisk AssessmentROC CurveSensitivity and SpecificitySex FactorsYoung AdultConceptsObstructive coronary artery diseaseCoronary artery diseaseCoronary angiographyNondiabetic patientsQuantitative coronary angiographyArtery diseasePresence of CADClinical modelMore major coronary arteriesPeripheral blood gene expressionBlood-based gene expression testDiamond-Forrester methodMulticenter prospective trialMajor coronary arteriesChronic inflammatory disordersIndependent validation cohortReceiver-operating characteristic analysisBlood gene expressionReal-time polymerase chain reactionWhole blood testCardiac protein markersGene expression testNoninvasive imaging methodProspective trialRisk patients