2006
Predictors of Recurrent In‐Stent Restenosis after Beta‐Radiation: An Analysis from the START 40/20 Trial
KANEDA H, HONDA Y, MORINO Y, LANSKY AJ, YOCK PG, BONAN R, FITZGERALD PJ. Predictors of Recurrent In‐Stent Restenosis after Beta‐Radiation: An Analysis from the START 40/20 Trial. Journal Of Interventional Cardiology 2006, 19: 376-380. PMID: 17020560, DOI: 10.1111/j.1540-8183.2006.00188.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceAngioplasty, Balloon, CoronaryBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCoronary AngiographyCoronary Artery BypassCoronary RestenosisFemaleFollow-Up StudiesHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRadiopharmaceuticalsRecurrenceStentsStrontium RadioisotopesTreatment OutcomeUltrasonography, InterventionalYttrium RadioisotopesConceptsTarget lesion revascularizationBalloon/artery ratioLesion revascularizationRecurrent ISRGeographic missArtery ratioStent restenosisPrimary catheter-based interventionMultivariate logistic regression analysisBeta-radiation therapyPredictors of recurrentRecurrence of stenosisTreatment of ISRLarge multicenter trialsMinimum lumen diameterCatheter-based interventionsPreliminary univariate analysisLogistic regression analysisIntravascular ultrasound parametersCohort patientsIndependent predictorsMulticenter trialDiameter stenosisUnivariate analysisBalloon sizing
2005
Two-year clinical follow-up of 90Sr/90 Y β-radiation versus placebo control for the treatment of in-stent restenosis
Silber S, Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Bass T, O'Neill W, Lasala J, Reisman M, Sharma SK, Kuntz RE, Bonan R, Investigators F. Two-year clinical follow-up of 90Sr/90 Y β-radiation versus placebo control for the treatment of in-stent restenosis. American Heart Journal 2005, 149: 689-694. PMID: 15990754, DOI: 10.1016/j.ahj.2004.05.061.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAnticoagulantsBeta ParticlesBrachytherapyCoronary AngiographyCoronary DiseaseCoronary RestenosisDiabetes ComplicationsDisease-Free SurvivalFemaleFollow-Up StudiesHumansLife TablesMaleMiddle AgedPrognosisStentsStrontium RadioisotopesThrombophiliaTreatment OutcomeYttrium RadioisotopesConceptsMajor adverse cardiac eventsTarget vessel revascularizationStent restenosisIntracoronary brachytherapyOriginal patientsPrimary safety end pointTwo-year clinical outcomesPlacebo-controlled randomized trialEnd pointAdverse cardiac eventsPlacebo-controlled studyPrimary end pointSafety end pointKaplan-Meier analysisInitial beneficial effectsRestenosis TrialVessel revascularizationCardiac eventsPlacebo armClinical followActive treatmentClinical outcomesRandomized trialsPlacebo controlPatients
2003
Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes
Suntharalingam M, Laskey WK, Tantibhedhyangkul W, Lansky A, Teirstein P, Bass T, Silber S, Rutherford B, Wilmer C, Popma JJ, Kuntz R, Bonan R. Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: 536-542. PMID: 12957267, DOI: 10.1016/s0360-3016(03)00537-6.Peer-Reviewed Original ResearchConceptsVessel revascularization ratePercutaneous coronary interventionDiabetic patientsNondiabetic patientsVascular brachytherapyNondiabetic counterpartsStent restenosisRevascularization ratesCoronary interventionLess target lesion revascularizationConventional percutaneous coronary interventionBinary angiographic restenosisAngiographic restenosis rateTarget lesion revascularizationReference vessel diameterComplex coronary lesionsMinimal lumen diameterStudy of patientsPercent diameter stenosisVessel diameterTreatment effectsBeta-Cath SystemBreslow-Day testLesion revascularizationAngiographic restenosis
2002
Randomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis
Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Massullo V, Bass T, Henderson R, Silber S, von Rottkay P, Bonan R, Ho KK, Osattin, MPH A, Kuntz RE. Randomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis. Circulation 2002, 106: 1090-1096. PMID: 12196334, DOI: 10.1161/01.cir.0000027814.96651.72.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationStent restenosisPlacebo-treated patientsPrimary end pointCatheter-based treatmentIn-Stent RestenosisPlacebo sourcesStent thrombosesAngiographic restenosisClinical restenosisFirst multicenterIntracoronary radiationMyocardial infarctionPlacebo controlPatientsPrescribed doseRestenosisConventional treatmentIntracoronary catheterEnd pointDay 244PlaceboRevascularizationTreatmentIncidenceClinical and angiographic outcomes after use of 90Strontium/90Yttrium beta radiation for the treatment of in-stent restenosis: results from the Stents and Radiation Therapy 40 (START 40) registry
Suntharalingam M, Laskey W, Lansky AJ, Waksman R, White L, Teirstien P, Massullo V, Rutherford B, Elman A, Kuntz RE, Popma JJ, Bonan R, Investigators T. Clinical and angiographic outcomes after use of 90Strontium/90Yttrium beta radiation for the treatment of in-stent restenosis: results from the Stents and Radiation Therapy 40 (START 40) registry. International Journal Of Radiation Oncology • Biology • Physics 2002, 52: 1075-1082. PMID: 11958904, DOI: 10.1016/s0360-3016(01)02712-2.Peer-Reviewed Original ResearchConceptsMinimum luminal diameterPlacebo groupStent restenosisAngiographic analysisInjury lengthBinary restenosisRevascularization ratesPlacebo armSTART trialSource trainTarget vessel revascularization rateMajor adverse cardiac eventsTarget lesion revascularization rateAdverse cardiac eventsLesion revascularization rateRepeat balloon angioplastyVessel revascularization rateTarget vessel revascularizationNative coronary arteriesManagement of patientsRate of restenosisQuantitative angiographic analysisResults of patientsLate aneurysm formationPercent diameter stenosis