2006
The randomised study of the double dose versus single dose sirolimus-eluting stent for the treatment of diabetic patients with de novo coronary lesions.
Costa RA, Sousa JE, Abizaid A, Chaves A, Feres F, Sousa AG, Musumeci G, Mehran R, Fitzgerald PJ, Lansky AJ, Leon MB, Shiran A, Halon DA, Lewis BS, Guagliumi G. The randomised study of the double dose versus single dose sirolimus-eluting stent for the treatment of diabetic patients with de novo coronary lesions. EuroIntervention 2006, 2: 295-301. PMID: 19755304.Peer-Reviewed Original ResearchDe novo coronary lesionsSirolimus-eluting stentsNovo coronary lesionsDiabetic patientsCoronary lesionsDouble doseRevascularisation ratesStent late lumen lossLesion revascularisation rateDouble-blind fashionLate lumen lossBare metal stentsIncomplete stent appositionBinary restenosisPrimary endpointStent thrombosisLumen lossLate thrombosesNeointimal proliferationProcedure successNeointimal volumeNeointimal hyperplasiaPatientsMetal stentsBlind fashionVolumetric Intravascular Ultrasound Assessment of Neointimal Hyperplasia and Nonuniform Stent Strut Distribution in Sirolimus-Eluting Stent Restenosis
Sano K, Mintz GS, Carlier SG, Fujii K, Takebayashi H, Kimura M, Costa JR, Tanaka K, Costa RA, Lui J, Weisz G, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps EM, Collins M, Stone GW, Moses JW, Leon MB. Volumetric Intravascular Ultrasound Assessment of Neointimal Hyperplasia and Nonuniform Stent Strut Distribution in Sirolimus-Eluting Stent Restenosis. The American Journal Of Cardiology 2006, 98: 1559-1562. PMID: 17145209, DOI: 10.1016/j.amjcard.2006.07.030.Peer-Reviewed Original ResearchConceptsMinimum lumen siteStent restenotic lesionsStent areaDiabetes mellitusLumen areaRestenotic lesionsStent strut distributionIH areaMinimal lumen area siteSirolimus-eluting stent implantationVolumetric intravascular ultrasound analysisIntravascular ultrasound assessmentMinimum stent areaIntravascular ultrasound analysisMinimum lumen areaMinimal lumen areaMinimal lumen siteIH responseSES implantationStent implantationUltrasound assessmentStent lengthNeointimal hyperplasiaStent restenosisStrut distribution
2004
Nonuniform Strut Distribution Correlates With More Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation
Takebayashi H, Mintz GS, Carlier S, Kobayashi Y, Fujii K, Yasuda T, Costa RA, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps E, Collins MB, Colombo A, Stone GW, Leon MB, Moses JW. Nonuniform Strut Distribution Correlates With More Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation. Circulation 2004, 110: 3430-3434. PMID: 15557367, DOI: 10.1161/01.cir.0000148371.53174.05.Peer-Reviewed Original ResearchConceptsMinimum lumen siteIntimal hyperplasiaLumen areaStent implantationStent strutsIH areaSmaller minimal lumen areaSirolimus-eluting stent implantationAmount of neointimaMinimum lumen areaMinimal lumen areaIVUS predictorsRestenosis patientsSES implantationRestenosis lesionsStent cellsStent strut distributionNeointimal hyperplasiaStrut distributionIntravascular ultrasoundMultivariate analysisVisible strutsComparison groupCross-sectional areaHyperplasia1101-44 Effect of everolimus-eluting stents in preventing neointimal hyperplasia: An intravascular ultrasound analysis from the FUTURE II trial
Sonoda S, Grube E, Shimada Y, Hassan A, Honda Y, Yock P, Chan C, Honda H, Kar S, Hauptmann K, Storger H, Lansky A, Fitzgerald P. 1101-44 Effect of everolimus-eluting stents in preventing neointimal hyperplasia: An intravascular ultrasound analysis from the FUTURE II trial. Journal Of The American College Of Cardiology 2004, 43: a66. DOI: 10.1016/s0735-1097(04)90276-8.Peer-Reviewed Original Research1059-6 The multicenter evaluation of the everolimus-eluting stent for inhibition of neointimal hyperplasia: Results of the pooled FUTURE I and II trials
Costa R, Lansky A, Mehran R, Tsuchiya Y, Cristea E, Gilutz Y, Coral M, Negoita M, Pop R, Rink M, Muller R, Techen G, Grube E. 1059-6 The multicenter evaluation of the everolimus-eluting stent for inhibition of neointimal hyperplasia: Results of the pooled FUTURE I and II trials. Journal Of The American College Of Cardiology 2004, 43: a12. DOI: 10.1016/s0735-1097(04)90045-9.Peer-Reviewed Original Research
2001
Serial intravascular ultrasound analysis of edge recurrence after intracoronary gamma radiation treatment of native artery in-stent restenosis lesions
Ahmed J, Mintz G, Waksman R, Lansky A, Mehran R, Wu H, Weissman N, Pichard A, Satler L, Kent K, Leon M. Serial intravascular ultrasound analysis of edge recurrence after intracoronary gamma radiation treatment of native artery in-stent restenosis lesions. The American Journal Of Cardiology 2001, 87: 1145-1149. PMID: 11356387, DOI: 10.1016/s0002-9149(01)01483-7.Peer-Reviewed Original ResearchConceptsLumen cross-sectional areaIntimal hyperplasia cross-sectional areaSerial intravascular ultrasound analysisMedia cross-sectional areaEdge recurrenceIntravascular ultrasound analysisCross-sectional areaStent restenosisExternal elastic membrane cross-sectional areaUltrasound analysisStent restenosis TrialStent restenosis lesionsDistal cross-sectional areasGreater decreaseGreater increaseRestenosis lesionsRestenosis TrialPositive remodelingProximal plaqueWashington RadiationNative coronariesMean lumenNeointimal hyperplasiaRecurrenceLesionsIntracoronary radiation with gamma wire inhibits recurrent in-stent restenosis
Waksman R, Bhargava B, Chan R, Sherman W, Pisch J, Mintz G, Lansky A, Ahmed J, Ricci N, Liprie S. Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis. Cardiovascular Revascularization Medicine 2001, 2: 63-68. PMID: 11340009, DOI: 10.1016/s1522-1865(00)00086-x.Peer-Reviewed Original ResearchConceptsIntracoronary gamma radiationTarget lesion revascularizationStent restenosisMyocardial infractionBaseline lesion lengthUnderwent bypass surgeryBinary restenosis rateEvent-free survivalNeointimal tissue proliferationInitial clinical trialsStent restenosis resultsSource wireLesion revascularizationRepeat PTCAAngiographic restenosisPrimary endpointRepeat revascularizationSecondary endpointsBypass surgeryRestenosis rateIntracoronary radiationProcedural successTherapeutic challengeClinical trialsNeointimal hyperplasia