2024
Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review
Patel K, Rathod K, Lansky A, Prendergast B, Kharbanda R, Mathur A, Perry R, Baumbach A. Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review. Stroke 2024, 55: 2754-2764. PMID: 39371005, DOI: 10.1161/strokeaha.124.047149.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementCerebrovascular eventsValve replacementAtrial fibrillationLow operative risk patientsAdvent of transcatheter aortic valve replacementNew-onset atrial fibrillationComplication of transcatheter aortic valve replacementIncreased risk of bleedingHigher risk of cerebrovascular eventsAssociated with significant mortalityTranscatheter aortic valve replacement procedureRisk of cerebrovascular eventsOperative risk patientsResults of embolizationRisk of bleedingRisk of thromboembolismHypoattenuated leaflet thickeningImprove risk stratificationCerebral lesion volumeAssociated with cerebrovascular eventsTherapy to patientsOverall stroke rateSeverity of comorbiditiesAngiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study
Bharadwaj A, Abu-Much A, Maini A, Zhou Z, Li Y, Batchelor W, Grines C, Baron S, Redfors B, Lansky A, Basir M, O’Neill W. Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study. Circulation Cardiovascular Interventions 2024, 17: e013503. PMID: 38708609, PMCID: PMC11239095, DOI: 10.1161/circinterventions.123.013503.Peer-Reviewed Original ResearchChronic kidney diseaseHigh-risk percutaneous coronary interventionPercutaneous coronary interventionAdvanced chronic kidney diseaseIII studiesCerebrovascular eventsAngiographic characteristicsClinical outcomesCoronary calcificationCoronary interventionSevere coronary calcificationCardiac Surgery scoreHigh-risk patientsLong-term outcomesPercutaneous coronary intervention complicationsPCI-related complicationsPrevalence of hypertensionPeripheral arterial diseaseCoronary complicationsBaseline comorbiditiesSurgery scoreArtery diseasePrimary outcomeEGFRKidney diseaseAssociation of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention
Medranda G, Faraz H, Thompson J, Zhang Y, Bharadwaj A, Osborn E, Abu-Much A, Lansky A, Basir M, Moses J, O’Neill W, Grines C, Baron S. Association of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101981. PMID: 39166169, PMCID: PMC11330901, DOI: 10.1016/j.jscai.2024.101981.Peer-Reviewed Original ResearchSYNTAX I scoreHigh-risk percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionSYNTAX IIII studiesSYNTAX scoreI scoresAssociated with higher ratesComplex coronary artery diseaseCoronary artery diseaseMultivariate regression analysisMechanical circulatory supportInterventionClinical outcomesPoor outcomeCerebrovascular eventsRegression analysisArtery diseasePost-PCIPatientsCirculatory supportProcedural factorsHigher ratesOutcomes
2023
Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI
Abu-Much A, Grines C, Batchelor W, Maini A, Zhang Y, Redfors B, Bellumkonda L, Bharadwaj A, Moses J, Truesdell A, Li Y, Baron S, Lansky A, Basir M, Cohen D, O'Neill W. Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI. American Heart Journal 2023, 269: 139-148. PMID: 38151142, DOI: 10.1016/j.ahj.2023.12.015.Peer-Reviewed Original ResearchBaseline LV ejection fractionLV ejection fractionPercutaneous coronary interventionPCI-related complicationsLV dysfunctionEjection fractionLV functionLeft main percutaneous coronary interventionHigh-risk percutaneous coronary interventionHigh-risk PCI patientsImmediate percutaneous coronary interventionMain percutaneous coronary interventionModerate LV dysfunctionSevere LV dysfunctionVentricular systolic dysfunctionVentricular ejection fractionCoronary complicationsLVEF groupMACCE rateCerebrovascular eventsPCI patientsSystolic dysfunctionCoronary interventionIII studyMyocardial infarctionPredictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study
Grubman D, Ahmad Y, Leipsic J, Blanke P, Pasupati S, Webster M, Nazif T, Parise H, Lansky A. Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study. The American Journal Of Cardiology 2023, 207: 28-34. PMID: 37722198, DOI: 10.1016/j.amjcard.2023.08.137.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementAtrial fibrillationHuman studiesEmbolic protection device useHigh embolic riskPrimary end pointHigh-risk patientsIndependent core laboratorySelf-expanding valvesComputed tomography angiographyProtection device useCerebral embolizationCerebrovascular eventsEmbolic riskAcute thrombusEmbolic burdenAngiography featuresTechnical successTomography angiographyEmbolic debrisValve useCore laboratoryEnd pointSex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study
Shah T, Abu-Much A, Batchelor W, Grines C, Baron S, Zhou Z, Li Y, Maini A, Redfors B, Hussain Y, Wollmuth J, Basir M, O'Neill W, Lansky A. Sex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study. JACC Cardiovascular Interventions 2023, 16: 1721-1729. PMID: 37409991, DOI: 10.1016/j.jcin.2023.04.036.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionFemale patientsIII studySex-based differencesImmediate PCISYNTAX scoreClinical outcomesMyocardial infarctionStroke/transient ischemic attackWorse renal functionAcute limb ischemiaTransient ischemic attackSex differencesPercutaneous coronary interventionAcute myocardial infarctionHigher ejection fractionCause deathCoronary complicationsIschemic attackMajor bleedingNonfemoral accessPercutaneous CoronaryPrior strokeCerebrovascular eventsVascular complications
2022
Safety and performance of a novel cerebral embolic protection device for transcatheter aortic valve implantation: the PROTEMBO C Trial.
Jagielak D, Targonski R, Frerker C, Abdel-Wahab M, Wilde J, Werner N, Lauterbach M, Leick J, Grygier M, Misterski M, Erglis A, Narbute I, Witkowski AR, Adam M, Frank D, Gatto F, Schmidt T, Lansky AJ. Safety and performance of a novel cerebral embolic protection device for transcatheter aortic valve implantation: the PROTEMBO C Trial. EuroIntervention 2022, 18: 590-597. PMID: 35608032, PMCID: PMC10241272, DOI: 10.4244/eij-d-22-00238.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve implantationLesion volumeValve implantationTechnical successC trialSingle lesionCerebral embolic protection devicesPerformance endpointBrain diffusion-weighted magnetic resonance imagingLarge single lesionsPrimary safety endpointBrain lesion volumeDiffusion-weighted magnetic resonance imagingCerebral protection systemSingle-arm studyEmbolic protection devicesPrimary performance endpointRate of deathMagnetic resonance imagingTAVI casesTAVI patientsVARC-2Cerebrovascular eventsPrimary endpointPercutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting for Treating In-Stent Restenosis in Unprotected-Left Main: LM-DRAGON-Registry
Wańha W, Bil J, Kołodziejczak M, Kowalówka A, Kowalewski M, Hudziak D, Gocoł R, Januszek R, Figatowski T, Milewski M, Tomasiewicz B, Kübler P, Hrymniak B, Desperak P, Kuźma Ł, Milewski K, Góra B, Łoś A, Kulczycki J, Włodarczak A, Skorupski W, Grygier M, Lesiak M, D'Ascenzo F, Andres M, Kleczynski P, Litwinowicz R, Borin A, Smolka G, Reczuch K, Gruchała M, Gil RJ, Jaguszewski M, Bartuś K, Suwalski P, Dobrzycki S, Dudek D, Bartuś S, Ga̧sior M, Ochała A, Lansky AJ, Deja M, Legutko J, Kedhi E, Wojakowski W. Percutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting for Treating In-Stent Restenosis in Unprotected-Left Main: LM-DRAGON-Registry. Frontiers In Cardiovascular Medicine 2022, 9: 849971. PMID: 35615559, PMCID: PMC9125786, DOI: 10.3389/fcvm.2022.849971.Peer-Reviewed Original ResearchPercutaneous coronary interventionTarget vessel revascularizationCoronary artery bypassCardiac deathMyocardial infarctionPCI groupArtery bypassCoronary interventionStent restenosisUnprotected left main coronary arteryLeft main coronary arteryMain coronary arteryManagement of patientsAnalysis of patientsCerebrovascular eventsPrimary endpointVessel revascularizationConsecutive patientsCoronary arteryCABGLower incidenceLower riskPatientsDeathMACCEImproved outcomes in patients with severely depressed LVEF undergoing percutaneous coronary intervention with contemporary practices
O'Neill WW, Anderson M, Burkhoff D, Grines CL, Kapur NK, Lansky AJ, Mannino S, McCabe JM, Alaswad K, Daggubati R, Wohns D, Meraj PM, Pinto DS, Popma JJ, Moses JW, Schreiber TL, Ohman E. Improved outcomes in patients with severely depressed LVEF undergoing percutaneous coronary intervention with contemporary practices. American Heart Journal 2022, 248: 139-149. PMID: 35192839, DOI: 10.1016/j.ahj.2022.02.006.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHigh-risk percutaneous coronary interventionPROTECT IIProTECT IIICoronary interventionDepressed LVEFIII studyIII patientsMyocardial infarctionStroke/transient ischemic attackTransient ischemic attackCompleteness of revascularizationPrior myocardial infarctionKaplan-Meier analysisDuration of supportHospital bleedingMACCE rateProcedural hypotensionCause mortalityCerebrovascular eventsIschemic attackJeopardy scorePrior CABGSYNTAX scoreHospital discharge