2024
Hypertension Control During the Coronavirus Disease 2019 Pandemic
Korves C, Peixoto A, Lucas B, Davies L, Weinberger D, Rentsch C, Vashi A, Young-Xu Y, King J, Asch S, Justice A. Hypertension Control During the Coronavirus Disease 2019 Pandemic. Medical Care 2024, 62: 196-204. PMID: 38284412, PMCID: PMC10922611, DOI: 10.1097/mlr.0000000000001971.Peer-Reviewed Original ResearchConceptsHypertension controlFollow-up intervalPrimary care clinic visitsFollow-up lengthVeterans Health AdministrationControlled hypertensionUncontrolled hypertensionGeneralized estimating equationsCohort of individualsStudy inclusion criteriaHealth careHealth AdministrationLonger follow-up intervalsBlood pressure measurementsAssessed associationsClinic visitsInclusion criteriaDecreased likelihoodEstimating equationsPrepandemic periodLow likelihoodCoronavirus diseaseFollow-upHypertensionIndividuals
2023
Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development
Garg K, Staunton M, Peixoto A, Wilson F, Ghazi L. Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development. American Journal Of Hypertension 2023, 37: 273-279. PMID: 37988620, DOI: 10.1093/ajh/hpad112.Peer-Reviewed Original ResearchBlood pressure reductionSevere hypertensionBP reductionPressure reductionRetrospective cohort studyChronic pulmonary diseaseMultivariable logistic regressionFuture treatment decisionsAntihypertensive medicationsAntihypertensive therapyCohort studyHypertension developmentBP dropHospitalized patientsPulmonary diseaseTreatment guidelinesBP treatmentWorse outcomesTreatment decisionsCardiac arrythmiasPatientsPotassium levelsHigh potassium levelsLogistic regressionDemographic characteristics
2022
Neurogenic orthostatic hypotension after treatment with sorafenib
Wippel C, Deshpande H, Patwa H, Peixoto A. Neurogenic orthostatic hypotension after treatment with sorafenib. BMJ Case Reports 2022, 15: e247140. PMID: 36549761, PMCID: PMC9791444, DOI: 10.1136/bcr-2021-247140.Peer-Reviewed Original ResearchConceptsOrthostatic hypotensionVascular endothelial growth factor inhibitorsLower extremity weaknessNeurogenic orthostatic hypotensionPalpable abdominal massGrowth factor inhibitorsHistory of fatigueAppropriate chronotropic responseSupine hypertensionAbdominal painAutonomic testingExtremity weaknessAbdominal massSodium intakeChronotropic responseFactor inhibitorsCompression stockingsDesmoid tumorsLiberal fluidsSympathetic responseHypotensionTumor growthSorafenibGradual improvementTreatmentEffect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatientsBlood pressure response to commonly administered antihypertensives for severe inpatient hypertension
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Peixoto AJ, Wilson FP. Blood pressure response to commonly administered antihypertensives for severe inpatient hypertension. PLOS ONE 2022, 17: e0265497. PMID: 35385506, PMCID: PMC8985959, DOI: 10.1371/journal.pone.0265497.Peer-Reviewed Original ResearchConceptsHTN developmentSevere hypertensionOral hydralazineOral carvedilolIntensive care unit patientsBlood pressure elevationCare unit patientsAssociation of treatmentSingle healthcare systemAntihypertensive treatmentCommon antihypertensivesInpatient hypertensionOral amlodipinePrescribed antihypertensivesOral metoprololClinical characteristicsCohort studyUnit patientsBP responseHospitalized patientsPressure elevationBP changesLower BPHypertensionHydralazineSevere inpatient hypertension prevalence and blood pressure response to antihypertensive treatment
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Townsend R, Peixoto A, Wilson FP. Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment. Journal Of Clinical Hypertension 2022, 24: 339-349. PMID: 35174627, PMCID: PMC8925013, DOI: 10.1111/jch.14431.Peer-Reviewed Original ResearchConceptsSevere hypertensionBlood pressure responseBP elevationUntreated patientsCox proportional hazards modelRetrospective cohort studyPressure responseProportional hazards modelAntihypertensive treatmentInpatient hypertensionMore comorbiditiesPossible overtreatmentHospitalized adultsCohort studyHypertension prevalenceArterial pressureHospitalized patientsTreatment guidelinesHypertensionGreater rateHazards modelPatientsAntihypertensivesTreatmentAdmissionExcessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension
Hanna J, Ghazi L, Yamamoto Y, Simonov M, Shah T, Wilson F, Peixoto A. Excessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension. American Journal Of Hypertension 2022, 35: 433-440. PMID: 35038322, PMCID: PMC9088839, DOI: 10.1093/ajh/hpac004.Peer-Reviewed Original ResearchConceptsAsymptomatic severe hypertensionBlood pressure responseSevere hypertensionHospitalized patientsPressure responseExcessive blood pressure responseMean arterial pressure reductionMAP reductionAcute kidney injuryBlood pressure declineArterial pressure reductionHours of administrationClonidine doseKidney injuryPrimary endpointAdverse eventsIschemic eventsBlood pressureIll patientsClinical groundsMedian timePatient sexFemale sexVascular diseaseMultivariable modelEvaluation and management of orthostatic hypotension: Limited data, limitless opportunity
Peixoto AJ. Evaluation and management of orthostatic hypotension: Limited data, limitless opportunity. Cleveland Clinic Journal Of Medicine 2022, 89: 36-45. PMID: 34983800, DOI: 10.3949/ccjm.89gr.22001.Peer-Reviewed Original Research
2021
ASSOCIATION BETWEEN CARDIOVASCULAR RISK ESTIMATION BY THE ASCVD RISK ESTIMATOR AND CAROTID-FEMORAL PULSE WAVE VELOCITY IN OLDER INDIVIDUALS
Ferreira-Filho S, Souza D, Freitas E, Peixoto A, Araujo L. ASSOCIATION BETWEEN CARDIOVASCULAR RISK ESTIMATION BY THE ASCVD RISK ESTIMATOR AND CAROTID-FEMORAL PULSE WAVE VELOCITY IN OLDER INDIVIDUALS. Journal Of Hypertension 2021, 39: e167. DOI: 10.1097/01.hjh.0000746248.89781.62.Peer-Reviewed Original ResearchThe Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study
Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCohort StudiesCOVID-19C-Reactive ProteinCreatinineDiureticsFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRespiration, ArtificialRisk FactorsSARS-CoV-2Severity of Illness IndexUnited StatesVasoconstrictor AgentsConceptsAcute kidney injurySARS-CoV-2Cohort studyRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testingTime-updated Cox proportional hazards modelsDialysis-requiring acute kidney injuryYale New Haven Health SystemHigher inflammatory marker levelsMore acute kidney injuryCox proportional hazards modelMulticenter cohort studyHigh rateInflammatory marker levelsTraditional risk factorsProportional hazards modelCoronavirus disease 2019KDIGO criteriaNephrotoxin exposureKidney injuryInjury independentUnivariable analysisNasopharyngeal samplesMarker levels
2020
Arterial Mechanics following Living Kidney Donation
Peixoto AJ. Arterial Mechanics following Living Kidney Donation. Clinical Journal Of The American Society Of Nephrology 2020, 15: 1237-1239. PMID: 32857062, PMCID: PMC7480545, DOI: 10.2215/cjn.12280720.Peer-Reviewed Original ResearchIs There a Role for Device Therapies in Resistant Hypertension?: The CON Side.
Peixoto AJ. Is There a Role for Device Therapies in Resistant Hypertension?: The CON Side. Kidney360 2020, 1: 9-13. PMID: 35372851, PMCID: PMC8808493, DOI: 10.34067/kid.0000742019.Peer-Reviewed Original ResearchChapter 46 Approach to the Patient with Hypertensive Nephrosclerosis
Peixoto A, Bakris G. Chapter 46 Approach to the Patient with Hypertensive Nephrosclerosis. 2020, 737-752. DOI: 10.1016/b978-0-12-815876-0.00046-2.Peer-Reviewed Original ResearchHypertensive nephrosclerosisEnd-stage renal diseaseBlood pressure controlChronic kidney diseaseRenin-angiotensin systemMechanism of injuryArteriolar myogenic responseNonmalignant hypertensionTuft collapseBase therapyImpaired autoregulationUnderlying diseaseRenal diseaseInterstitial fibrosisKidney diseaseGlomerular hypertensionUrine sedimentMyogenic responsePressure controlHypertensionGene mutationsDiseaseNephrosclerosisPatientsProteinuria
2019
Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality
Chang J, Guo X, Rao V, Gromisch ES, Chung S, Kluger HM, Cha C, Gorelick F, Testani J, Safirstein R, Crowley S, Peixoto AJ, Desir GV. Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality. Kidney International Reports 2019, 5: 362-368. PMID: 32154458, PMCID: PMC7056858, DOI: 10.1016/j.ekir.2019.12.002.Peer-Reviewed Original ResearchAcute Severe Hypertension
Peixoto AJ. Acute Severe Hypertension. New England Journal Of Medicine 2019, 381: 1843-1852. PMID: 31693807, DOI: 10.1056/nejmcp1901117.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCerebral HemorrhageElectrocardiographyFemaleHumansHypertensionHypertrophy, Left VentricularInfusions, IntravenousIntensive Care UnitsMedication AdherenceMiddle AgedPosterior Leukoencephalopathy SyndromePractice Guidelines as TopicSeronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma
Gao CA, Weber UM, Peixoto AJ, Weiss SA. Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma. Journal For ImmunoTherapy Of Cancer 2019, 7: 262. PMID: 31623673, PMCID: PMC6796437, DOI: 10.1186/s40425-019-0748-0.Peer-Reviewed Original ResearchConceptsAutoimmune autonomic ganglionopathyImmune checkpoint inhibitor therapyMetastatic melanomaCheckpoint inhibitorsDual immune checkpoint inhibitionSympathetic nervous system responsesBackgroundImmune checkpoint inhibitorsCardiovascular autonomic testingCheckpoint inhibitor therapyImmune checkpoint inhibitionNervous system responsesEndocrine workupHypotension refractoryAutonomic testingImmunomodulatory therapyAdverse eventsCase presentationAFluid resuscitationInhibitor therapyCheckpoint inhibitionClinical outcomesDisease progressionNew symptomsEndocrine toxicityNivolumabMON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA
Rao V, Guo X, Chang J, Peixoto A, Testani J, Desir G. MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA. Kidney International Reports 2019, 4: s67. DOI: 10.1016/j.ekir.2019.05.180.Peer-Reviewed Original ResearchSAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY
Desir G, Chang J, Guo X, Gromisch E, Peixoto A. SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY. Kidney International Reports 2019, 4: s84-s85. DOI: 10.1016/j.ekir.2019.05.217.Peer-Reviewed Original Research
2018
Arterial stiffness in elderly patients with normotension and hypertension in Brazil
de Mendonça G, de Souza D, de Alvarenga Cunha Brunelli A, de Oliveira Peres C, Freitas EGB, Lacerda GN, Dorneles MC, Peixoto AJ, Ferreira‐Filho S. Arterial stiffness in elderly patients with normotension and hypertension in Brazil. Journal Of Clinical Hypertension 2018, 20: 1285-1293. PMID: 30039916, PMCID: PMC8031136, DOI: 10.1111/jch.13358.Peer-Reviewed Original ResearchConceptsAortic augmentation indexArterial stiffnessUncontrolled hypertensionCarotid-femoral pulse wave velocityHigher aortic augmentation indexCf-PWV levelsCf-PWV valuesBlood pressure levelsPulse wave velocityCross-sectional analysisElderly patientsAugmentation indexBP levelsCf-PWVEntire cohortNormotensionHypertensionOlder individualsOlder populationPatientsTonometry dataCore measuresCohortPressure levelsIndividuals
2016
Assessment of Hypertension in Chronic Kidney Disease
Peixoto A. Assessment of Hypertension in Chronic Kidney Disease. 2016, 15-33. DOI: 10.1007/978-1-4939-6436-9_2.Peer-Reviewed Original ResearchChronic kidney diseaseKidney diseaseHypertensive patientsAccurate blood pressure measurementHypertension-related outcomesAmbulatory BP monitoringOffice BP measurementsClinical trial evidenceAssessment of hypertensionDiagnosis of hypertensionBlood pressure measurementsAmbulatory BPBP monitoringTrial evidenceOffice readingsBP measurementsUse of homePatientsHypertensionDiseasePreferred methodPressure measurementsDiagnosis