2024
Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging
Feher A, Bednarski B, Miller R, Shanbhag A, Lemley M, Miras L, Sinusas A, Miller E, Slomka P. Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266761. PMID: 38548351, PMCID: PMC11064832, DOI: 10.2967/jnumed.123.266761.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingHF hospitalizationHeart failureStress left ventricular ejection fractionPerfusion imagingHF exacerbationPredictive of HF hospitalizationsSPECT/CT myocardial perfusion imagingMyocardial perfusionInternational cohortAcute heart failure exacerbationMedian follow-upVentricular ejection fractionReceiver-operating-characteristic curveClinical risk factorsHeart failure exacerbationExternal validation cohortAcute HF exacerbationPrevent HF hospitalizationsImaging parametersCalcium scoreEjection fractionClinical parametersCT scanValidation cohort
2023
Fibroblast activation protein: Pivoting cancer/chemotherapeutic insight towards heart failure
Gehris J, Ervin C, Hawkins C, Womack S, Churillo A, Doyle J, Sinusas A, Spinale F. Fibroblast activation protein: Pivoting cancer/chemotherapeutic insight towards heart failure. Biochemical Pharmacology 2023, 219: 115914. PMID: 37956895, PMCID: PMC10824141, DOI: 10.1016/j.bcp.2023.115914.Peer-Reviewed Original ResearchMeSH KeywordsExtracellular MatrixFibroblastsHeart FailureHumansMyocardiumNeoplasmsVentricular RemodelingConceptsFibroblast activation proteinExtracellular matrixCancer progressionFibroblast subtypesProtein signaturesECM structureEnzyme pathwaysActivation proteinTherapeutic targetImportant mechanismFibroblastsProliferationFibroblast growthProteinProgressionPathwayRemodelingFunctionCancerDiscoveryChemotherapeuticsTargeted imaging of angiogenesis post-myocardial infarction predicts development of heart failure.
Sinusas A. Targeted imaging of angiogenesis post-myocardial infarction predicts development of heart failure. Journal Of Nuclear Cardiology 2023, 30: 2085-2088. PMID: 38245156, DOI: 10.1007/s12350-023-03347-8.Peer-Reviewed Original ResearchTargeted imaging of angiogenesis post-myocardial infarction predicts development of heart failure
Sinusas A. Targeted imaging of angiogenesis post-myocardial infarction predicts development of heart failure. Journal Of Nuclear Cardiology 2023, 30: 2085-2088. PMID: 37495762, DOI: 10.1007/s12350-023-03347-8.Peer-Reviewed Original Research