2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac outputDuSFE: Dual-Channel Squeeze-Fusion-Excitation co-attention for cross-modality registration of cardiac SPECT and CT
Chen X, Zhou B, Xie H, Guo X, Zhang J, Duncan J, Miller E, Sinusas A, Onofrey J, Liu C. DuSFE: Dual-Channel Squeeze-Fusion-Excitation co-attention for cross-modality registration of cardiac SPECT and CT. Medical Image Analysis 2023, 88: 102840. PMID: 37216735, PMCID: PMC10524650, DOI: 10.1016/j.media.2023.102840.Peer-Reviewed Original ResearchConceptsCross-modality registrationConvolutional layersCo-attention mechanismMultiple convolutional layersCo-attention moduleDifferent convolutional layersMedical image registrationInput data streamDeep learning strategiesLow registration errorIntensity-based registration methodCardiac SPECTΜ-mapsDeep learningFeature fusionData streamsInput imageSource codeFeature mapsNeural networkImage registrationSpatial featuresRegistration performanceRegistration methodInput information
2022
Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography
Ahn S, Ta K, Thorn S, Onofrey J, Melvinsdottir I, Lee S, Langdon J, Sinusas A, Duncan J. Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography. Medical Image Analysis 2022, 84: 102711. PMID: 36525845, PMCID: PMC9812938, DOI: 10.1016/j.media.2022.102711.Peer-Reviewed Original ResearchConceptsSpatial transformer networkMotion trackingNoisy displacement fieldReliable motion estimationMotion tracking methodCardiac strain analysisTransformer networkDisplacement fieldDisplacement pathsMotion fieldTracking methodMotion estimationExperimental resultsStrain analysisSuperior performanceTemporal constraintsCardiac motionTrackingRegularization functionDependent featuresEchocardiography imagesNetworkPrior assumptionsField
2019
Molecular Imaging of the Heart
Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ. Molecular Imaging of the Heart. 2019, 9: 477-533. PMID: 30873600, DOI: 10.1002/cphy.c180007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular diseaseRisk stratificationCardiovascular molecular imagingMultimodality cardiovascular imagingIschemic heart failureMolecular imagingMolecular imaging targetsPositron emission tomographySingle photon emissionNumerous cardiovascular diseasesClinical molecular imagingEjection fractionHeart failureMedical therapySystemic diseaseMyocardial infarctionPathophysiological changesCardiac functionEarly diagnosisDisease processCardiac arrhythmiasEmission tomographyCardiovascular imagingImaging strategiesPhoton emission
2017
Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT
Liu Q, Mohy-ud-Din H, Boutagy N, Jiang M, Ren S, Stendahl J, Sinusas A, Liu C. Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Physics In Medicine And Biology 2017, 62: 3944-3957. PMID: 28266929, PMCID: PMC5568763, DOI: 10.1088/1361-6560/aa6520.Peer-Reviewed Original ResearchConceptsMulti-atlas segmentation methodLabel fusion methodMulti-atlas segmentationSegmentation methodConventional label fusion methodsFusion methodManual segmentationMultiple organ segmentationLabel fusion algorithmImage qualityCardiac SPECT imagesDice similarity coefficientOrgan segmentationSegmentation accuracyAutomatic segmentationCTA segmentationFusion algorithmComputed tomography angiography dataSegmentationOne-out approachCT datasetsTomography angiography dataSimilarity coefficientAngiography dataConsistent image quality
2016
High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function
Palyo RJ, Sinusas A, Liu YH. High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function. Journal Of Nuclear Medicine 2016, 57: 893-899. PMID: 26848173, DOI: 10.2967/jnumed.115.164632.Peer-Reviewed Original ResearchConceptsMyocardial perfusion SPECTEjection fractionDose reductionMyocardial perfusionAnterior descendingRight coronary artery territoryTetrofosmin myocardial perfusion SPECTNormal MPS resultsNuclear Cardiology guidelinesCoronary artery territoryLarge perfusion defectsLV ejection fractionLeft anterior descendingData of patientsNormal myocardial perfusionEnd-systolic volumeRelative dose reductionDefect sizeMPS resultsShort imaging protocolsTetrofosmin scanArtery territoryCardiology guidelinesSubstantial dose reductionLV function
2014
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptake
2001
Estimation of coronary flow reserve: Can SPECT compete with other modalities?
Gullberg G, Di Bella E, Sinusas A. Estimation of coronary flow reserve: Can SPECT compete with other modalities? Journal Of Nuclear Cardiology 2001, 8: 620-625. PMID: 11593228, DOI: 10.1067/mnc.2001.118121.Peer-Reviewed Original ResearchQuantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images
Sinusas A, Papademetris X, Constable R, Dione D, Slade M, Shi P, Duncan J. Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images. AJP Heart And Circulatory Physiology 2001, 281: h698-h714. PMID: 11454574, DOI: 10.1152/ajpheart.2001.281.2.h698.Peer-Reviewed Original Research
2000
Technetium 99m-N-NOET: Although not equivalent to thallium-201, it still offers new opportunities
Sinusas A. Technetium 99m-N-NOET: Although not equivalent to thallium-201, it still offers new opportunities. Journal Of Nuclear Cardiology 2000, 7: 185-188. PMID: 10796010, DOI: 10.1016/s1071-3581(00)90043-6.Peer-Reviewed Original Research
1999
The potential for myocardial imaging with hypoxia markers
Sinusas A. The potential for myocardial imaging with hypoxia markers. Seminars In Nuclear Medicine 1999, 29: 330-338. PMID: 10534235, DOI: 10.1016/s0001-2998(99)80020-8.Peer-Reviewed Original ResearchQuantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method
Liu Y, Sinusas A, DeMan P, Zaret B, Wackers F. Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method. Journal Of Nuclear Cardiology 1999, 6: 190-203. PMID: 10327104, DOI: 10.1016/s1071-3581(99)90080-6.Peer-Reviewed Original Research
1998
Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy
Mattera J, Arain S, Sinusas A, Finta L, Wackers F. Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy. Journal Of Nuclear Cardiology 1998, 5: 498-506. PMID: 9796897, DOI: 10.1016/s1071-3581(98)90181-7.Peer-Reviewed Original ResearchConceptsExercise myocardial perfusion imagingCoronary artery diseaseNormal exercise electrocardiogramMyocardial perfusion imagingNormal myocardial perfusion imagingNormal resting electrocardiogramsExercise electrocardiogramExercise testingArtery diseaseIntermediate likelihoodResting electrocardiogramsAbnormal myocardial perfusion imagingDiagnostic strategiesAbnormal exercise electrocardiogramGroup 3 patientsHard cardiac eventsNonfatal myocardial infarctionNormal baseline electrocardiogramSubsequent coronary revascularizationIncremental diagnostic informationDiagnostic testing strategiesCoronary revascularizationCardiac eventsUnstable anginaConsecutive patientsExperimental evaluation of radiotracers: Role of intact biological models
Sinusas A. Experimental evaluation of radiotracers: Role of intact biological models. Journal Of Nuclear Cardiology 1998, 5: 167-183. PMID: 9588669, DOI: 10.1016/s1071-3581(98)90200-8.Peer-Reviewed Original ResearchPhysical and geometrical modeling for image-based recovery of left ventricular deformation
Duncan J, Shi P, Constable T, Sinusas A. Physical and geometrical modeling for image-based recovery of left ventricular deformation. Progress In Biophysics And Molecular Biology 1998, 69: 333-351. PMID: 9785945, DOI: 10.1016/s0079-6107(98)00014-5.Peer-Reviewed Original Research
1997
Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo.
Young L, Renfu Y, Russell R, Hu X, Caplan M, Ren J, Shulman G, Sinusas A. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation 1997, 95: 415-22. PMID: 9008459, DOI: 10.1161/01.cir.95.2.415.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportDogsFluorescent Antibody TechniqueGlucose Transporter Type 1Glucose Transporter Type 4HeartIntracellular MembranesMonosaccharide Transport ProteinsMuscle ProteinsMyocardial IschemiaMyocardiumRegional Blood FlowSarcolemmaSubcellular FractionsTissue Distribution
1996
Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects
Siebelink H, Natale D, Sinusas A, Wackers F. Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects. Journal Of Nuclear Cardiology 1996, 3: 483-493. PMID: 8989673, DOI: 10.1016/s1071-3581(96)90058-6.Peer-Reviewed Original ResearchConceptsDefect reversibilitySingle photon emissionDual-isotope SPECTNormal databaseStress-rest single-photon emissionTechnetium 99m-labeled sestamibiStress-induced myocardial ischemiaStress single-photon emissionPerfusion defect reversibilityPrior myocardial infarctionDefect sizeRest/stressSingle-isotope imagingMyocardial infarctionThallium SPECTMyocardial ischemiaIndividual patientsMyocardial perfusionThallium-201PatientsSestamibiCircumferential count profilesTomographic imagingImaging protocolDual-isotope imagingQuantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model
Liu Y, Sinusas A, Shi C, Shen M, Dione D, Heller E, Wackers F. Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model. Journal Of Nuclear Cardiology 1996, 3: 312-320. PMID: 8799250, DOI: 10.1016/s1071-3581(96)90091-4.Peer-Reviewed Original ResearchConceptsMyocardial blood flowRelative blood flowRelative myocardial blood flowRegional myocardial blood flowCoronary artery occlusionBlood flowSingle photon emissionArtery occlusionCanine modelShort-axis slicesEx vivoSestamibi single-photon emissionMyocardial countsFlow deficitsMyocardial count densityNormal blood flowMean countsRegional myocardial perfusionCount profilesMIBI uptakeMIBI SPECTSestamibi SPECTMyocardial perfusionCircumferential count profilesRelative regional myocardial blood flow
1995
Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia.
Ng C, Sinusas A, Zaret B, Soufer R. Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia. Circulation 1995, 92: 1261-8. PMID: 7648674, DOI: 10.1161/01.cir.92.5.1261.Peer-Reviewed Original Research
1994
One-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging
Raiker K, Sinusas A, Wackers F, Zaret B. One-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging. Journal Of Nuclear Cardiology 1994, 1: 449-456. PMID: 9420729, DOI: 10.1007/bf02961599.Peer-Reviewed Original ResearchConceptsNondiagnostic exercise electrocardiogramsPositive exercise electrocardiogramExercise electrocardiogramPrognostic significanceSingle photon emissionHigher cardiac event rateCardiac event rateChest pain syndromeNegative exercise electrocardiogramNonfatal myocardial infarctionOne-year prognosisPositive stress electrocardiogramCoronary artery diseaseFavorable prognostic significanceMyocardial perfusion imagingStress perfusion imagesCardiac causesCardiac eventsPain syndromeArtery diseaseConsecutive patientsExercise SPECTMyocardial infarctionFavorable outcomeStress electrocardiogram