2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac outputSegmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network
Xie H, Liu Z, Shi L, Greco K, Chen X, Zhou B, Feher A, Stendahl J, Boutagy N, Kyriakides T, Wang G, Sinusas A, Liu C. Segmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network. IEEE Transactions On Medical Imaging 2023, 42: 1325-1336. PMID: 36459599, PMCID: PMC10204821, DOI: 10.1109/tmi.2022.3226604.Peer-Reviewed Original Research
2019
Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis
Parajuli N, Lu A, Ta K, Stendahl J, Boutagy N, Alkhalil I, Eberle M, Jeng GS, Zontak M, O'Donnell M, Sinusas AJ, Duncan JS. Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis. Medical Image Analysis 2019, 55: 116-135. PMID: 31055125, PMCID: PMC6939679, DOI: 10.1016/j.media.2019.04.007.Peer-Reviewed Original ResearchConceptsDeformation/strainExcellent tracking accuracyEntire cardiac cycleTracking accuracyCardiac motion analysisAccurate estimationSurface pointsEchocardiographic image sequencesLV motionDisplacementMotion analysisImage sequencesCardiac cyclePoint matchingMotionConsecutive framesEstimationNetwork trackingImportant characteristicsSignificant promiseSchemeGood correlationFlow
2017
Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT
Liu Q, Mohy-ud-Din H, Boutagy N, Jiang M, Ren S, Stendahl J, Sinusas A, Liu C. Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Physics In Medicine And Biology 2017, 62: 3944-3957. PMID: 28266929, PMCID: PMC5568763, DOI: 10.1088/1361-6560/aa6520.Peer-Reviewed Original ResearchConceptsMulti-atlas segmentation methodLabel fusion methodMulti-atlas segmentationSegmentation methodConventional label fusion methodsFusion methodManual segmentationMultiple organ segmentationLabel fusion algorithmImage qualityCardiac SPECT imagesDice similarity coefficientOrgan segmentationSegmentation accuracyAutomatic segmentationCTA segmentationFusion algorithmComputed tomography angiography dataSegmentationOne-out approachCT datasetsTomography angiography dataSimilarity coefficientAngiography dataConsistent image quality
2001
Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images
Sinusas A, Papademetris X, Constable R, Dione D, Slade M, Shi P, Duncan J. Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images. AJP Heart And Circulatory Physiology 2001, 281: h698-h714. PMID: 11454574, DOI: 10.1152/ajpheart.2001.281.2.h698.Peer-Reviewed Original ResearchEstimation of 3D left ventricular deformation from echocardiography
Papademetris X, Sinusas A, Dione D, Duncan J. Estimation of 3D left ventricular deformation from echocardiography. Medical Image Analysis 2001, 5: 17-28. PMID: 11231174, DOI: 10.1016/s1361-8415(00)00022-0.Peer-Reviewed Original ResearchConceptsDense motion fieldIsotropic linear elastic modelRegional cardiac deformationLinear elastic modelMotion fieldTerms of strainCardiac deformationFiber directionElastic modelDeformationHeart wallGood agreementHeart deformationImage sequencesWallEstimationSpecific directionUltrasound imagesQuantitative estimationInitial correspondenceField
2000
Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model
Daher E, Dione D, Heller E, Holahan J, DeMan P, Shen M, Hu J, Sinusas A. Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model. Journal Of Nuclear Cardiology 2000, 7: 112-122. PMID: 10796000, DOI: 10.1016/s1071-3581(00)90031-x.Peer-Reviewed Original ResearchConceptsCoronary flow reserveRemote nonischemic regionsProximal occlusionNonischemic regionsThickening fractionCanine modelDistal occlusionCoronary flowIschemic areaFlow reserveMechanical etiologyLeft ventricleLeft circumflex artery regionAnterior descending (LAD) coronary artery occlusionProgressive decreaseAnesthetized open-chest canine modelCoronary artery occlusionExtent of ischemiaGlobal hemodynamic parametersProximal coronary occlusionRegional ischemic dysfunctionAcute canine modelImportant clinical implicationsOpen-chest canine modelMicrosphere blood flowTechnetium 99m-N-NOET: Although not equivalent to thallium-201, it still offers new opportunities
Sinusas A. Technetium 99m-N-NOET: Although not equivalent to thallium-201, it still offers new opportunities. Journal Of Nuclear Cardiology 2000, 7: 185-188. PMID: 10796010, DOI: 10.1016/s1071-3581(00)90043-6.Peer-Reviewed Original ResearchSevere regional ischemia alters coronary flow reserve in the remote perfusion area
Wu J, Yun J, Dione D, Heller E, Deckelbaum L, Sinusas A. Severe regional ischemia alters coronary flow reserve in the remote perfusion area. Journal Of Nuclear Cardiology 2000, 7: 43-52. PMID: 10698234, DOI: 10.1067/mnc.2000.99189.Peer-Reviewed Original ResearchConceptsLAD coronary flow reserveCoronary flow reserveLCX stenosisFlow reserveImpairment of CFRStenosis severityRemote nonischemic regionsRate-pressure productRegional myocardial dysfunctionDoppler flow probesTransstenotic pressure gradientOpen-chest dogsAcute canine modelIschemic dysfunctionAnterior descendingIntracoronary injectionMyocardial dysfunctionProximal LCXCoronary stenosisMyocardial infarctionAcute ischemiaProgressive impairmentPerfusion areaRegional myocardial flowTransstenotic gradient
1998
Additive Effects of Hyperinsulinemia and Ischemia on Myocardial GLUT1 and GLUT4 Translocation In Vivo
Russell R, Yin R, Caplan M, Hu X, Ren J, Shulman G, Sinusas A, Young L. Additive Effects of Hyperinsulinemia and Ischemia on Myocardial GLUT1 and GLUT4 Translocation In Vivo. Circulation 1998, 98: 2180-2186. PMID: 9815873, DOI: 10.1161/01.cir.98.20.2180.Peer-Reviewed Original Research
1997
Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo.
Young L, Renfu Y, Russell R, Hu X, Caplan M, Ren J, Shulman G, Sinusas A. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation 1997, 95: 415-22. PMID: 9008459, DOI: 10.1161/01.cir.95.2.415.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportDogsFluorescent Antibody TechniqueGlucose Transporter Type 1Glucose Transporter Type 4HeartIntracellular MembranesMonosaccharide Transport ProteinsMuscle ProteinsMyocardial IschemiaMyocardiumRegional Blood FlowSarcolemmaSubcellular FractionsTissue Distribution
1996
Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model
Liu Y, Sinusas A, Shi C, Shen M, Dione D, Heller E, Wackers F. Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model. Journal Of Nuclear Cardiology 1996, 3: 312-320. PMID: 8799250, DOI: 10.1016/s1071-3581(96)90091-4.Peer-Reviewed Original ResearchConceptsMyocardial blood flowRelative blood flowRelative myocardial blood flowRegional myocardial blood flowCoronary artery occlusionBlood flowSingle photon emissionArtery occlusionCanine modelShort-axis slicesEx vivoSestamibi single-photon emissionMyocardial countsFlow deficitsMyocardial count densityNormal blood flowMean countsRegional myocardial perfusionCount profilesMIBI uptakeMIBI SPECTSestamibi SPECTMyocardial perfusionCircumferential count profilesRelative regional myocardial blood flow
1994
Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging
Constable R, Rath K, Sinusas A, Gore J. Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging. Magnetic Resonance In Medicine 1994, 32: 33-42. PMID: 8084235, DOI: 10.1002/mrm.1910320106.Peer-Reviewed Original ResearchDoes myocardial free fatty acid metabolism predict subsequent mechanical dysfunction associated with cardiomyopathy?
Sinusas A. Does myocardial free fatty acid metabolism predict subsequent mechanical dysfunction associated with cardiomyopathy? Journal Of Nuclear Cardiology 1994, 1: 218-220. PMID: 9420690, DOI: 10.1007/bf02984095.Peer-Reviewed Original Research
1990
Experimental studies of the physiologic properties of technetium-99m isonitriles
Beller G, Sinusas A. Experimental studies of the physiologic properties of technetium-99m isonitriles. The American Journal Of Cardiology 1990, 66: e5-e8. PMID: 2145747, DOI: 10.1016/0002-9149(90)90605-z.Peer-Reviewed Original Research
1989
Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201
Sinusas A, Watson D, Cannon J, Beller G. Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201. Journal Of The American College Of Cardiology 1989, 14: 1785-1793. PMID: 2584570, DOI: 10.1016/0735-1097(89)90034-x.Peer-Reviewed Original ResearchConceptsLow coronary flowThallium-201Postischemic dysfunctionMyocardial uptakeArtery occlusionMethoxyisobutyl isonitrileEndocardial flowCoronary flowGroup II dogsTwo-dimensional echocardiographyEffects of ischemiaRegional blood flowOpen-chest canine modelMyocardial perfusion agentEpicardial segmentsRadionuclide injectionBlood flowEndocardial segmentsRegional dysfunctionIschemic regionLeft ventricleCanine modelDysfunctionGroup IPerfusion agent