2024
Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApnea
2020
IMPAIRED CORONARY FLOW RESERVE ON 82RUBIDIUM POSITRON EMISSION TOMOGRAPHY IMAGING PREDICTS ADVERSE EVENTS IN PATIENTS WITH AUTOIMMUNE DISEASE
Feher A, Boutagy N, Oikonomou E, Miller E, Sinusas A, Hinchcliff M. IMPAIRED CORONARY FLOW RESERVE ON 82RUBIDIUM POSITRON EMISSION TOMOGRAPHY IMAGING PREDICTS ADVERSE EVENTS IN PATIENTS WITH AUTOIMMUNE DISEASE. Journal Of The American College Of Cardiology 2020, 75: 1726. DOI: 10.1016/s0735-1097(20)32353-6.Peer-Reviewed Original Research
2000
Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model
Daher E, Dione D, Heller E, Holahan J, DeMan P, Shen M, Hu J, Sinusas A. Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model. Journal Of Nuclear Cardiology 2000, 7: 112-122. PMID: 10796000, DOI: 10.1016/s1071-3581(00)90031-x.Peer-Reviewed Original ResearchConceptsCoronary flow reserveRemote nonischemic regionsProximal occlusionNonischemic regionsThickening fractionCanine modelDistal occlusionCoronary flowIschemic areaFlow reserveMechanical etiologyLeft ventricleLeft circumflex artery regionAnterior descending (LAD) coronary artery occlusionProgressive decreaseAnesthetized open-chest canine modelCoronary artery occlusionExtent of ischemiaGlobal hemodynamic parametersProximal coronary occlusionRegional ischemic dysfunctionAcute canine modelImportant clinical implicationsOpen-chest canine modelMicrosphere blood flowSevere regional ischemia alters coronary flow reserve in the remote perfusion area
Wu J, Yun J, Dione D, Heller E, Deckelbaum L, Sinusas A. Severe regional ischemia alters coronary flow reserve in the remote perfusion area. Journal Of Nuclear Cardiology 2000, 7: 43-52. PMID: 10698234, DOI: 10.1067/mnc.2000.99189.Peer-Reviewed Original ResearchConceptsLAD coronary flow reserveCoronary flow reserveLCX stenosisFlow reserveImpairment of CFRStenosis severityRemote nonischemic regionsRate-pressure productRegional myocardial dysfunctionDoppler flow probesTransstenotic pressure gradientOpen-chest dogsAcute canine modelIschemic dysfunctionAnterior descendingIntracoronary injectionMyocardial dysfunctionProximal LCXCoronary stenosisMyocardial infarctionAcute ischemiaProgressive impairmentPerfusion areaRegional myocardial flowTransstenotic gradient
1997
Acute ischemic left ventricular dysfunction alters coronary flow reserve in remote nonischemic region
Daher E, Dione D, Heller E, DeMan P, Shen M, Hu J, Sinusas A. Acute ischemic left ventricular dysfunction alters coronary flow reserve in remote nonischemic region. Journal Of Nuclear Cardiology 1997, 4: s44. DOI: 10.1016/s1071-3581(97)91289-7.Peer-Reviewed Original Research