2024
A computational account of the development and evolution of psychotic symptoms.
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024 PMID: 39260466, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityDiminished signal-to-noise ratioComputational accountPsychiatric interventionNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationA computational account of the development and evolution of psychotic symptoms
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024, 5 PMID: 38699166, PMCID: PMC11065053, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityComputational accountPsychiatric interventionDiminished signal-to-noise ratioNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formation
2023
Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms
Oliva H, Monteiro-Junior R, Oliva I, Powers A. Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 125: 110771. PMID: 37075881, DOI: 10.1016/j.pnpbp.2023.110771.Peer-Reviewed Original ResearchConceptsExercise interventionGeneral symptomsPsychotic symptomsEfficacy of exerciseEffects of exerciseSpecific brain areasWeb of ScienceCochrane CENTRALSymptom improvementTemporal lobeBrain areasLarge effect sizesPsychotic patientsPositive symptomsNegative symptomsSymptomsNeurobiological mechanismsNeurophysiology studiesInterventionExerciseEffect sizeDatabase searchSignificant improvementNeurobiological modelsPatients
2022
A computational lens on menopause-associated psychosis
Fisher VL, Ortiz LS, Powers AR. A computational lens on menopause-associated psychosis. Frontiers In Psychiatry 2022, 13: 906796. PMID: 35990063, PMCID: PMC9381820, DOI: 10.3389/fpsyt.2022.906796.Peer-Reviewed Original ResearchEstrogen declinePsychotic symptomsNew-onset psychosisPathogenesis of psychosisPsychotic episodeNeural pathwaysSymptom presentationAge groupsImpair functioningProtective factorsPsychosisRisk periodSymptomsPatient-specific pathwaysDisease statesEarly adulthoodBiological correlatesNeural mechanismsEstrogenSex differencesEpisodesLatent stateExtreme distressMenopausePathogenesisConditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility
Kafadar E, Fisher VL, Quagan B, Hammer A, Jaeger H, Mourgues C, Thomas R, Chen L, Imtiaz A, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Benrimoh D, Sheldon AD, Lim C, Mathys C, Powers AR. Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility. Biological Psychiatry 2022, 92: 772-780. PMID: 35843743, PMCID: PMC10575690, DOI: 10.1016/j.biopsych.2022.05.007.Peer-Reviewed Original ResearchConceptsCH rateIncoming sensory evidenceSensory evidencePerceptual statesTask performanceComputational psychiatrySubset of participantsPrior expectationsHallucination severityBehavioral dataSymptom severityPast experienceStable measureHallucinationsPsychotic symptomsHallucination frequencyTaskSymptom expressionBayesian modelState markerHallucinatorsNonhallucinatorsOverweightingPerceptionSymptom risk
2021
Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction
Benrimoh D, Sheldon A, Sibarium E, Powers AR. Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction. Frontiers In Psychiatry 2021, 12: 685390. PMID: 34385938, PMCID: PMC8353084, DOI: 10.3389/fpsyt.2021.685390.Peer-Reviewed Original ResearchComputational modelAssertive community treatmentProcessing-based accountExperience of psychosisEvidence-based clinical interventionsCommunity treatmentPrevious computational modelsCognitive resourcesPositive psychotic symptomsComputational underpinningsComputational mechanismsSocial interactionStrong social elementSensory informationPositive symptomsConceptual reviewClinical interventionsEarly psychosisSocial elementsCandidate mechanismPsychotic symptomsNeurobiologyPsychosisConceptual paperMultiple levels