2023
A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing
Drusko A, Baumeister D, McPhee Christensen M, Kold S, Fisher V, Treede R, Powers A, Graven-Nielsen T, Tesarz J. A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing. Scientific Reports 2023, 13: 3196. PMID: 36823292, PMCID: PMC9950064, DOI: 10.1038/s41598-023-29758-8.Peer-Reviewed Original ResearchConceptsHierarchical Gaussian FilterPrior expectationsRelevant individual differencesPain perceptionLearning-based interventionsTesting paradigmCognitive processesSensory evidenceIndividual differencesPsychophysical paradigmInferential processesVisual cuesElectrical cutaneous stimulusPrior weightingPerceptionPain stimuliPrior beliefsIndividual levelNociceptive inputBeliefsGreater relianceStimuliStrong weightingAcute pain stimuliParadigm
2022
Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone
2020
Modeling perception and behavior in individuals at clinical high risk for psychosis: Support for the predictive processing framework
Kafadar E, Mittal VA, Strauss GP, Chapman HC, Ellman LM, Bansal S, Gold JM, Alderson-Day B, Evans S, Moffatt J, Silverstein SM, Walker EF, Woods SW, Corlett PR, Powers AR. Modeling perception and behavior in individuals at clinical high risk for psychosis: Support for the predictive processing framework. Schizophrenia Research 2020, 226: 167-175. PMID: 32593735, PMCID: PMC7774587, DOI: 10.1016/j.schres.2020.04.017.Peer-Reviewed Original ResearchConceptsClinical high riskCHR participantsDegraded speech stimuliPredictive processing frameworkUtility of interventionsSample of participantsPerceptual inferenceSensory evidencePsychotic spectrum disordersSpeech stimuliSpeech taskComputational underpinningsBehavioral tasksEfficacy of interventionsSpectrum disorderTarget tonesParticipants' performanceComputational modelingHigh riskPoor recognitionLatent factorsSuch tasksPrior beliefsTaskAppropriate risk stratificationS197. PAVLOVIAN CONDITIONED HALLUCINATIONS TASKS AND PSYCHOMETRIC THRESHOLDING IN ENRICHED ONLINE SAMPLE
Kafadar E, Lim C, Powers A. S197. PAVLOVIAN CONDITIONED HALLUCINATIONS TASKS AND PSYCHOMETRIC THRESHOLDING IN ENRICHED ONLINE SAMPLE. Schizophrenia Bulletin 2020, 46: s113-s114. PMCID: PMC7234405, DOI: 10.1093/schbul/sbaa031.263.Peer-Reviewed Original ResearchAuditory verbal hallucinationsEmergence of hallucinationsAuditory stimuliNeural signaturesVisual stimuliUnusual experiencesOnline sampleIncoming sensory evidencePavlovian conditioning taskPredictive coding frameworkSalient auditory stimuliPrior beliefsPerceptual inferenceSensory evidencePerceptual experienceConditioning taskBrain processesTask methodologyResponses of participantsSensory modalitiesVerbal hallucinationsPotential therapeutic targetTask consistHallucinatory experiencesDiagnosis of psychosis
2018
Hallucinations and Strong Priors
Corlett PR, Horga G, Fletcher PC, Alderson-Day B, Schmack K, Powers AR. Hallucinations and Strong Priors. Trends In Cognitive Sciences 2018, 23: 114-127. PMID: 30583945, PMCID: PMC6368358, DOI: 10.1016/j.tics.2018.12.001.Peer-Reviewed Original ResearchConceptsAberrant perceptionsClinical hallucinationsRecent empirical workConstructive natureHuman behaviorIdentifiable stimuliEmpathic approachPrior beliefsLight of workPerceptionHallucinationsEmpirical workStrong priorsReal worldLaboratory phenomenonNeural networkStimuliApparent disconnectBeliefsPsychosisIndividualsHealthy subjectsSupportInference