Social determinants associated with Zika virus infection in pregnant women
Nery N, Ticona J, Gambrah C, Doss-Gollin S, Aromolaran A, Rastely-Júnior V, Lessa M, Sacramento GA, Cruz JS, de Oliveira D, dos Santos LL, da Silva CG, Botosso VF, Soares CP, Araujo DB, Oliveira DB, dos Santos Alves RP, Andreata-Santos R, Durigon EL, de Souza Ferreira LC, Wunder EA, Khouri R, Oliveira-Filho J, de Siqueira IC, Almeida ARP, Reis MG, Ko AI, Costa F. Social determinants associated with Zika virus infection in pregnant women. PLOS Neglected Tropical Diseases 2021, 15: e0009612. PMID: 34329305, PMCID: PMC8323902, DOI: 10.1371/journal.pntd.0009612.Peer-Reviewed Original ResearchConceptsPregnant womenSocial determinantsZIKV exposureZIKV infectionZika virusPlaque reduction neutralization testReferral maternity hospitalZika virus infectionReduction neutralization testCross-sectional studyKey social determinantsZIKV resultsClinical characteristicsMaternity hospitalRisk factorsVirus infectionExposure statusSociodemographic determinantsNeutralization testMultivariate analysisInfection riskLogistic regressionLower educationFuture interventionsInfectionDiverse functional autoantibodies in patients with COVID-19
Wang EY, Mao T, Klein J, Dai Y, Huck JD, Jaycox JR, Liu F, Zhou T, Israelow B, Wong P, Coppi A, Lucas C, Silva J, Oh JE, Song E, Perotti ES, Zheng NS, Fischer S, Campbell M, Fournier JB, Wyllie AL, Vogels CBF, Ott IM, Kalinich CC, Petrone ME, Watkins AE, Dela Cruz C, Farhadian S, Schulz W, Ma S, Grubaugh N, Ko A, Iwasaki A, Ring A. Diverse functional autoantibodies in patients with COVID-19. Nature 2021, 595: 283-288. PMID: 34010947, DOI: 10.1038/s41586-021-03631-y.Peer-Reviewed Original ResearchConceptsPeripheral immune cell compositionSARS-CoV-2 infectionCOVID-19Effects of autoantibodiesTissue-associated antigensSpecific clinical characteristicsInnate immune activationImmune cell compositionCOVID-19 exhibitCOVID-19 manifestsAnalysis of autoantibodiesSARS-CoV-2Functional autoantibodiesMouse surrogateClinical characteristicsVirological controlClinical outcomesImmune activationMild diseaseAsymptomatic infectionAutoantibody reactivityDisease progressionHealthcare workersHigh prevalenceAutoantibodiesClinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient population