2022
Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity
Elsamadicy A, Sandhu M, Reeves B, Sherman J, Craft S, Williams M, Shin J, Sciubba D. Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity. Clinical Neurology And Neurosurgery 2022, 224: 107532. PMID: 36436433, DOI: 10.1016/j.clineuro.2022.107532.Peer-Reviewed Original ResearchConceptsNon-routine dischargeHealthcare resource utilizationAdverse eventsGeriatric cohortMME useGeriatric patientsSpinal fusionSpine deformityMultivariate logistic regression analysisInpatient narcotic consumptionInpatient opioid consumptionInpatient opioid usePremier Healthcare DatabasePoor surgical outcomesPatient risk stratificationPosterior spinal fusionAdult spinal deformityAdult spine deformityICD-10-CM codesGreater proportionLogistic regression analysisGreater resource utilizationNon-Hispanic whitesOlder CohortOpioid consumption
2021
Post-traumatic seizures following pediatric traumatic brain injury
Elsamadicy AA, Koo AB, David WB, Lee V, Zogg CK, Kundishora AJ, Hong C, Reeves BC, Sarkozy M, Kahle KT, DiLuna M. Post-traumatic seizures following pediatric traumatic brain injury. Clinical Neurology And Neurosurgery 2021, 203: 106556. PMID: 33636505, DOI: 10.1016/j.clineuro.2021.106556.Peer-Reviewed Original ResearchConceptsLoss of consciousnessTraumatic brain injuryPost-traumatic seizuresSeizure developmentBrain injuryRisk factorsPre-existing medical comorbiditiesPediatric traumatic brain injuryClinical risk factorsDevelopment of seizuresRate of seizuresDecrease healthcare costsEtiology of injuryType of injuryLogistic regression analysisQuality of careHospital complicationsMedical comorbiditiesNeurological complicationsPediatric patientsTBI patientsGreater proportionNinth RevisionSubarachnoid hemorrhageSecondary diagnosis
2020
Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury
Williamson T, Ryser MD, Ubel PA, Abdelgadir J, Spears CA, Liu B, Komisarow J, Lemmon ME, Elsamadicy A, Lad SP. Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury. JAMA Surgery 2020, 155: 723-731. PMID: 32584926, PMCID: PMC7301301, DOI: 10.1001/jamasurg.2020.1790.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryLife-supporting treatmentTraumatic brain injuryBrain injurySurgeons Trauma Quality Improvement Program databaseTrauma Quality Improvement Program databaseLower Glasgow Coma Scale scoreHigher Injury Severity ScoreQuality Improvement Program databaseGlasgow Coma Scale scoreImprovement Program databaseInjury Severity ScoreSelf-pay patientsDependent health statusOlder patientsAdult patientsClinical factorsWhite patientsBlack patientsMultivariable analysisTrauma centerDisseminated cancerSeverity scoreProgram databaseRetrospective analysisRisk Factors for the Development of Post-Traumatic Hydrocephalus in Children
Elsamadicy AA, Koo AB, Lee V, David WB, Zogg CK, Kundishora AJ, Hong CS, DeSpenza T, Reeve BC, DiLuna M, Kahle KT. Risk Factors for the Development of Post-Traumatic Hydrocephalus in Children. World Neurosurgery 2020, 141: e105-e111. PMID: 32389871, PMCID: PMC7484270, DOI: 10.1016/j.wneu.2020.04.216.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryRisk factorsBrain injuryNationwide Emergency Department Sample databasePost-traumatic hydrocephalusClinical risk factorsDevelopment of hydrocephalusNeurologic complicationsRespiratory complicationsPediatric patientsHydrocephalus developmentNinth RevisionSubarachnoid hemorrhageEmergency departmentSecondary diagnosisPrimary diagnosisSubdural hemorrhageClinical ModificationInternational ClassificationHydrocephalusHemorrhagePatientsBaseline returnSample databaseAge 6Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease
Kemeny HR, Elsamadicy AA, Farber SH, Champion CD, Lorrey SJ, Chongsathidkiet P, Woroniecka KI, Cui X, Shen SH, Rhodin KE, Tsvankin V, Everitt J, Sanchez-Perez L, Healy P, McLendon RE, Codd PJ, Dunn IF, Fecci PE. Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease. Clinical Cancer Research 2020, 26: 1141-1151. PMID: 31744830, PMCID: PMC7809696, DOI: 10.1158/1078-0432.ccr-18-3486.Peer-Reviewed Original ResearchConceptsCushing's diseasePituitary adenomasPD-L1PD1/PD-L1 axisAdrenocorticotropic hormone plasma levelsTumor-infiltrating T cellsRefractory Cushing's diseasePD-L1 axisPD-L1 expressionCheckpoint blockade therapyNovel therapeutic optionsHormone plasma levelsElevated cortisol levelsLymphocytic hypophysitisAntitumor immunityBlockade therapyCheckpoint blockadeCheckpoint expressionNumerous sequelaeSignificant morbidityTherapeutic optionsPlasma levelsPreclinical modelsT cellsSuccessful therapyIndependent Association Between Type of Intraoperative Blood Transfusion and Postoperative Delirium After Complex Spinal Fusion for Adult Deformity Correction.
Elsamadicy AA, Adil SM, Charalambous L, Drysdale N, Koo AB, Lee M, Kundishora AJ, Camara-Quintana J, Kolb L, Laurans M, Abbed K, Karikari IO. Independent Association Between Type of Intraoperative Blood Transfusion and Postoperative Delirium After Complex Spinal Fusion for Adult Deformity Correction. Spine 2020, 45: 268-274. PMID: 31996654, DOI: 10.1097/brs.0000000000003260.Peer-Reviewed Original ResearchConceptsIntraoperative blood transfusionComplex spinal fusionAllogenic blood transfusionPostoperative deliriumBlood transfusionSpinal fusionIndependent associationDeformity correctionMultivariate nominal-logistic regression analysisPrimary complex spinal fusionAdult spine deformity patientsAdult deformity correctionBetter overall patient careGreater complication risksRetrospective cohort studySpine deformity patientsOverall patient careNominal logistic regression analysisMajor academic institutionHospital stayCohort studyBlood lossPrimary outcomeComplication riskDeformity patients
2019
Glioneuronal Tumor With Features of Ganglioglioma and Neurocytoma Arising in the Fourth Ventricle: A Report of 2 Unusual Cases and a Review of Infratentorial Gangliogliomas
Harrison W, Elsamadicy AA, McMahon JT, Chagoya G, Sobel RA, McLendon RE, Adamson C. Glioneuronal Tumor With Features of Ganglioglioma and Neurocytoma Arising in the Fourth Ventricle: A Report of 2 Unusual Cases and a Review of Infratentorial Gangliogliomas. Journal Of Neuropathology & Experimental Neurology 2019, 78: 780-787. PMID: 31361005, DOI: 10.1093/jnen/nlz060.Peer-Reviewed Original ResearchConceptsFeatures of gangliogliomaGlioneuronal tumorInfratentorial gangliogliomasFourth ventricleRosette-forming glioneuronal tumorDistinct histologic entityUnusual adult casesPapillary glioneuronal tumorSurgical resectionSurgical excisionHistologic featuresAdult casesGlioneuronal neoplasmHistologic entityClinical significanceDysplastic gangliocytomaHistologic combinationCerebellar liponeurocytomaGangliogliomaUnusual caseTumorsRare occurrenceNeurocytomaDistinct findingsNeoplasmsReduced Impact of Obesity on Short-Term Surgical Outcomes, Patient-Reported Pain Scores, and 30-Day Readmission Rates After Complex Spinal Fusion (≥7 Levels) for Adult Deformity Correction
Elsamadicy AA, Camara-Quintana J, Kundishora AJ, Lee M, Freedman IG, Long A, Qureshi T, Laurans M, Tomak P, Karikari IO. Reduced Impact of Obesity on Short-Term Surgical Outcomes, Patient-Reported Pain Scores, and 30-Day Readmission Rates After Complex Spinal Fusion (≥7 Levels) for Adult Deformity Correction. World Neurosurgery 2019, 127: e108-e113. PMID: 30876992, DOI: 10.1016/j.wneu.2019.02.165.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBody Mass IndexComorbidityDiabetes MellitusDyslipidemiasElective Surgical ProceduresFemaleHeart DiseasesHumansHypertensionLaminectomyLength of StayMaleMiddle AgedObesityPain, PostoperativePatient ReadmissionPatient Reported Outcome MeasuresPostoperative ComplicationsPrevalencePulmonary Disease, Chronic ObstructiveRetrospective StudiesSpinal DiseasesSpinal FusionTreatment OutcomeUnited StatesYoung AdultConceptsPatient-reported pain scoresComplex spinal fusionPain scoresImpact of obesityReadmission ratesSurgical outcomesDeformity correctionSpinal fusionAmbulatory statusPatient demographicsComplication ratePreoperative body mass indexPrimary complex spinal fusionShort-term surgical outcomesAdult deformity correctionInferior surgical outcomesPostoperative complication profileLength of surgeryPostoperative complication ratePrevalence of obesityBody mass indexPatient-reported outcomesComplex spinal surgeryPaucity of dataMajor academic institution
2018
Key Role of Preoperative Recumbent Films in the Treatment of Severe Sagittal Malalignment
Karikari IO, Lenke LG, Bridwell KH, Tauchi R, Kelly MP, Sugrue PA, Bumpass DB, Elsamadicy AA, Adogwa O, Lalezari R, Koester L, Blanke K, Gum J. Key Role of Preoperative Recumbent Films in the Treatment of Severe Sagittal Malalignment. Spine Deformity 2018, 6: 568-575. PMID: 30122393, DOI: 10.1016/j.jspd.2018.02.009.Peer-Reviewed Original ResearchConceptsPreoperative lumbar lordosisRadiographic parametersLumbar lordosisRadiographic outcomesSM patientsSevere SMLL-PI mismatchSevere sagittal malalignmentRetrospective cohort studyThree-column osteotomySagittal radiographic parametersODI scoresCohort studySuboptimal improvementSagittal malalignmentOverall improvementSpinal realignmentDeformity correctionBACKGROUND DATAInclusion criteriaSupine radiographsFlexible deformitiesPelvic tiltPatientsSRS domains
2017
Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States
Charalambous LT, Premji A, Tybout C, Hunt A, Cutshaw D, Elsamadicy AA, Yang S, Xie J, Giamberardino C, Pagadala P, Perfect JR, Lad SP. Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. Journal Of Medical Microbiology 2017, 67: 215-227. PMID: 29244019, PMCID: PMC6557145, DOI: 10.1099/jmm.0.000656.Peer-Reviewed Original ResearchConceptsHealthcare resource utilizationFungal meningitisCryptococcal meningitisMeningitis patientsTruven Health Analytics MarketScan databaseLong-term morbidityLength of stayLarge longitudinal cohortHealth economic impactCandida meningitisLong followMarketScan databasePrimary diagnosisLongitudinal cohortOverall burdenCandidiasis patientsMeningitisHistoplasmosis patientsMeningitis diagnosisPatientsOriginal diagnosisSingle pathogenPrevalent typeDiagnosisUnited StatesComplications and 30-Day readmission rates after craniotomy/craniectomy: A single Institutional study of 243 consecutive patients
Elsamadicy AA, Sergesketter A, Adogwa O, Ongele M, Gottfried ON. Complications and 30-Day readmission rates after craniotomy/craniectomy: A single Institutional study of 243 consecutive patients. Journal Of Clinical Neuroscience 2017, 47: 178-182. PMID: 29031542, DOI: 10.1016/j.jocn.2017.09.021.Peer-Reviewed Original ResearchConceptsSensory/motor deficitsConsecutive patientsUnplanned readmissionReadmission ratesMotor deficitsMental statusPost-operative complication rateCommon presented symptomsHigher health care costsEarly hospital readmissionDays of dischargeCraniotomy/craniectomyHigher readmission ratesMajority of patientsSingle institutional studySkilled nursing facilitiesQuality of careHealth care costsHealth care dollarsMajor academic institutionComplication ratePatient demographicsSD ageCommon indicationHospital readmission
2016
Racial Disparities in 30-Day Readmission Rates After Elective Spine Surgery
Adogwa O, Elsamadicy AA, Mehta AI, Cheng J, Bagley CA, Karikari IO. Racial Disparities in 30-Day Readmission Rates After Elective Spine Surgery. Spine 2016, 41: 1677-1682. PMID: 27054453, DOI: 10.1097/brs.0000000000001616.Peer-Reviewed Original ResearchConceptsElective spine surgerySpine surgeryReadmission ratesBlack patientsUnplanned readmissionIndependent predictorsWhite patientsOutcome measuresMultivariate logistic regression modelRacial disparitiesCauses of readmissionDays of dischargeRetrospective cohort reviewRisk-adjusted oddsHigher readmission ratesBody mass indexPost-discharge careMain outcome measuresMultivariate logistic regressionMajor academic medical centerAcademic medical centerLogistic regression modelsHospital stayNonsurgical complicationsBaseline characteristicsImpact of Age on Change in Self-Image 5 Years After Complex Spinal Fusion (≥5 Levels)
Elsamadicy AA, Adogwa O, Sergesketter A, Behrens S, Hobbs C, Bridwell KH, Karikari IO. Impact of Age on Change in Self-Image 5 Years After Complex Spinal Fusion (≥5 Levels). World Neurosurgery 2016, 97: 112-116. PMID: 27713066, DOI: 10.1016/j.wneu.2016.09.095.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesComplex spinal fusionImpact of ageSpinal fusionComplication ratePreoperative variablesSignificant differencesImportant patient-reported outcomeFusion levelsPostoperative complication rateTypes of complicationsDeformity correction surgeryStandard deviation numberSRS-22rAdult patientsBaseline characteristicsEffect of ageIntraoperative variablesPatient demographicsSelf-image scoresYounger patientsPrimary outcomeCorrective surgeryCorrection surgeryPatients' perceptionsPreoperative Nutritional Status is an Independent Predictor of 30-day Hospital Readmission After Elective Spine Surgery
Adogwa O, Elsamadicy AA, Mehta AI, Cheng J, Bagley CA, Karikari IO. Preoperative Nutritional Status is an Independent Predictor of 30-day Hospital Readmission After Elective Spine Surgery. Spine 2016, 41: 1400-1404. PMID: 26953667, DOI: 10.1097/brs.0000000000001551.Peer-Reviewed Original ResearchConceptsElective spine surgeryPreoperative serum albumin levelDays of dischargeIndependent risk factorSerum albumin levelHospital readmissionSpine surgeryRisk factorsReadmission ratesPreoperative malnutritionMalnourished patientsAlbumin levelsIndependent predictorsThirty-day hospital readmission ratesNutritional statusMultivariate logistic regression analysisPre-operative malnutritionPreoperative nutritional statusUnplanned hospital readmissionModifiable risk factorsPostoperative complication rateRetrospective cohort reviewHospital readmission ratesIdentification of patientsMajor academic medical centerDo measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes?
Adogwa O, Elsamadicy AA, Han JL, Cheng J, Karikari I, Bagley CA. Do measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes? Journal Of Neurosurgery Spine 2016, 25: 689-696. PMID: 26722957, DOI: 10.3171/2015.8.spine15476.Peer-Reviewed Original ResearchConceptsTransforaminal lumbar interbody fusionLumbar spine surgeryAnterior lumbar interbody fusionLong-term outcomesLateral interbody fusionLumbar interbody fusionSpine surgeryInterbody fusionSurgical effectivenessOutcome measuresSF-36 physical component summary scorePhysical component summary scoreLongitudinal assessmentPatient-reported outcome instrumentsAchievement of MCIDMultiinstitutional prospective studyVAS leg painComponent summary scoresClinical outcome dataPatient-centered measuresLogistic regression modelingIneffective patient careInstitutional registryOutcomes RegistrySF-36