2024
Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis
Aghajanian S, Mohammadifard F, Kohandel Gargari O, Naeimi A, Bahadorimonfared A, Elsamadicy A. Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis. Neurosurgical Review 2024, 47: 177. PMID: 38644447, DOI: 10.1007/s10143-024-02424-x.Peer-Reviewed Original ResearchConceptsNetwork meta-analysisRate of complicationsBlood lossSpine surgeryEpsilon-aminocaproic acidMeta-analysisTranexamic acidEfficacy of antifibrinolyticsPediatric spine surgeryPerioperative blood lossReduce blood lossStandardized outcome dataRandomized clinical trialsStandard of carePerioperative bleedingTransfusion volumeTransfusion rateAntifibrinolytic agentsMassive transfusionPediatric patientsSafety profilePediatric surgeryProbability of efficacyAntifibrinolyticsClinical trialsRacial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis
Elsamadicy A, Sayeed S, Sherman J, Hengartner A, Pennington Z, Hersh A, Lo S, Shin J, Mendel E, Sciubba D. Racial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis. Journal Of Neuro-Oncology 2024, 166: 293-301. PMID: 38225469, DOI: 10.1007/s11060-023-04557-3.Peer-Reviewed Original ResearchConceptsRacial disparitiesTumor characteristicsEwing sarcomaWhite patientsOsseous neoplasmsAssociated with tumor characteristicsImpact of racial disparitiesNon-Hispanic whitesAssociated with reduced survivalPrimary osseous neoplasmsUtilization of chemotherapyProportion of black patientsFive-year survivalOutcomes of patientsProportion of blacksNon-white patientsCancer RegistryHispanic cohortMedian survivalRare tumorHispanic patientsStudy patientsTumor typesEnd ResultsRace patients
2023
Differences in Outcomes and Health Care Resource Utilization After Surgical Intervention for Metastatic Spinal Column Tumor in Safety-Net Hospitals
Elsamadicy A, Koo A, David W, Reeves B, Sherman J, Craft S, Hersh A, Duvall J, Lo S, Shin J, Mendel E, Sciubba D. Differences in Outcomes and Health Care Resource Utilization After Surgical Intervention for Metastatic Spinal Column Tumor in Safety-Net Hospitals. Spine 2023, 48: 800-809. PMID: 36972069, DOI: 10.1097/brs.0000000000004643.Peer-Reviewed Original ResearchConceptsSpinal column tumorsSNH statusPostoperative complicationsDischarge dispositionMultivariable analysisTumor surgeryMetastatic spinal tumor surgeryHealth care resource utilizationNationwide Inpatient Sample databaseICD-10-CM codingNonroutine discharge dispositionObservational cohort studySpinal tumor surgerySafety-net hospitalNonroutine dischargeSNH patientsHospital lengthStudy patientsAdult patientsCohort studyIntraoperative variablesExtended LOSIndependent predictorsLonger LOSProlonged hospitalizationA current review of spinal meningiomas: epidemiology, clinical presentation and management
Elsamadicy A, Reeves B, Craft S, Sherman J, Koo A, Sayeed S, Sarkozy M, Kolb L, Lo S, Shin J, Sciubba D, Mendel E. A current review of spinal meningiomas: epidemiology, clinical presentation and management. Journal Of Neuro-Oncology 2023, 161: 395-404. PMID: 36637710, DOI: 10.1007/s11060-023-04238-1.Peer-Reviewed Original ResearchConceptsSpinal meningiomasClinical presentationTumor developmentAdverse postoperative outcomesBenign spinal tumorsBenign spine tumorsRecent treatment recommendationsCharacteristic imaging findingsSubsequent tumor developmentPostoperative outcomesReceptor statusSpine tumorsImaging findingsSpinal tumorsCase reportTreatment recommendationsClinical evaluationClinical trialsGoogle Scholar searchOperative techniqueIntracranial meningiomasRadiation modalitiesSystematic reviewMeningiomasTumor genetics
2022
Differences in Health Care Resource Utilization After Surgery for Metastatic Spinal Column Tumors in Patients with a Concurrent Affective Disorder in the United States
Elsamadicy AA, Koo AB, Sarkozy M, Reeves BC, Pennington Z, Havlik J, Sandhu MR, Hersh A, Patel S, Kolb L, Larry Lo SF, Shin JH, Mendel E, Sciubba DM. Differences in Health Care Resource Utilization After Surgery for Metastatic Spinal Column Tumors in Patients with a Concurrent Affective Disorder in the United States. World Neurosurgery 2022, 161: e252-e267. PMID: 35123021, DOI: 10.1016/j.wneu.2022.01.112.Peer-Reviewed Original ResearchConceptsLength of stayHealth care resource utilizationPostoperative adverse eventsNonroutine dischargeAdverse eventsAffective disordersNational Inpatient Sample databaseMultivariate logistic regression analysisSpinal column metastasesRetrospective cohort studyMetastatic spinal tumorsSpinal column tumorsLogistic regression analysisConcurrent affective disorderGreater total costsRegression analysisMultivariate regression analysisAdult patientsCohort studyDischarge dispositionIntraoperative variablesPatient demographicsHospital admissionIndependent predictorsSpinal metastases
2021
Utility of expanded anterior column resection versus decompression-alone for local control in the management of carcinomatous vertebral column metastases undergoing adjuvant stereotactic radiotherapy
Pennington Z, Pairojboriboon S, Chen X, Sacino A, Elsamadicy AA, de la Garza Ramos R, Patel J, Elder BD, Kleinberg LR, Sciubba DM, Redmond KJ, Lo SL. Utility of expanded anterior column resection versus decompression-alone for local control in the management of carcinomatous vertebral column metastases undergoing adjuvant stereotactic radiotherapy. The Spine Journal 2021, 22: 835-846. PMID: 34718175, DOI: 10.1016/j.spinee.2021.10.016.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyLong-term local controlLocal recurrenceLocal controlAnterior columnTumor pathologyCommon primary tumor typesSingle comprehensive cancer centerAdjuvant stereotactic radiotherapySpinal column metastasesVertebral Column MetastasesRetrospective cohort studyLocal control ratePrimary tumor typeLocal tumor recurrenceComprehensive cancer centerKaplan-Meier functionInvasive surgical techniquesEpidural removalAdjuvant radiotherapySurgical debulkingCohort studyDisease resectionSpinal metastasesTumor involvementCost and Health Care Resource Utilization Differences After Spine Surgery for Bony Spine versus Primary Intradural Spine Tumors
Elsamadicy AA, Koo AB, Reeves BC, Freedman IG, Pennington Z, David WB, Ehresman J, Hengartner A, Laurans M, Kolb L, Shin JH, Sciubba DM. Cost and Health Care Resource Utilization Differences After Spine Surgery for Bony Spine versus Primary Intradural Spine Tumors. World Neurosurgery 2021, 151: e286-e298. PMID: 33866030, DOI: 10.1016/j.wneu.2021.04.015.Peer-Reviewed Original ResearchConceptsLength of stayPrimary intradural spinal tumorsIntradural spinal tumorsSpine tumorsSpine surgeryPerioperative complicationsSpinal tumorsNational Inpatient Sample databaseMultivariable logistic regression analysisStepwise multivariable logistic regression analysisBackward stepwise multivariable logistic regression analysisIntradural spinal neoplasmsIntradural spine tumorsRetrospective cohort studyLogistic regression analysisHealth care resourcesMore comorbiditiesAdult patientsCohort studyDischarge dispositionIntraoperative variablesPatient demographicsComplication rateHospital admissionIndependent predictors
2020
Thirty- and 90-day Readmissions After Spinal Surgery for Spine Metastases
Elsamadicy AA, Koo AB, David WB, Zogg CK, Kundishora AJ, Hong CS, Kuzmik GA, Gorrepati R, Coutinho PO, Kolb L, Laurans M, Abbed K. Thirty- and 90-day Readmissions After Spinal Surgery for Spine Metastases. Spine 2020, 46: 828-835. PMID: 33394977, PMCID: PMC8278805, DOI: 10.1097/brs.0000000000003907.Peer-Reviewed Original ResearchConceptsSpine metastasesGenitourinary complicationsPostoperative infectionSpine surgeryRheumatoid arthritis/collagen vascular diseasesAcute post-hemorrhagic anemiaCollagen vascular diseaseRetrospective cohort studyUnplanned hospital readmissionNationwide Readmissions DatabasePatient-level factorsVulnerable patient groupSurgical treatment interventionMultivariate regression analysisFusion spine surgeryInpatient complicationsFrequent readmissionsUnplanned readmissionCohort studyRenal failureClinical factorsHospital readmissionSurgery typePatient groupVascular diseaseInfluence of gender on discharge disposition after spinal fusion for adult spine deformity correction
Elsamadicy AA, Freedman IG, Koo AB, David WB, Lee M, Kundishora AJ, Kuzmik GA, Gorrepati R, Hong CS, Kolb L, Laurans M, Abbed K. Influence of gender on discharge disposition after spinal fusion for adult spine deformity correction. Clinical Neurology And Neurosurgery 2020, 194: 105875. PMID: 32388244, DOI: 10.1016/j.clineuro.2020.105875.Peer-Reviewed Original ResearchConceptsDischarge dispositionSpine deformity correctionSpinal fusionFemale cohortMale cohortDeformity correctionElective spine fusion surgeryNon-routine discharge dispositionNationwide Inpatient Sample databaseSpine surgical careSurgical site hematomaNon-routine dischargeElective spinal fusionICD-9 codesSpine fusion surgeryInfluence of genderPostoperative MIPostoperative UTIHospital staySite hematomaHospital factorsIndependent predictorsMale patientsFemale patientsFusion surgery
2019
Reduced Influence of Affective Disorders on 6-Week and 3-Month Narcotic Refills After Primary Complex Spinal Fusions for Adult Deformity Correction: A Single-Institutional Study
Elsamadicy AA, Charalambous L, Adil SM, Drysdale N, Lee M, Koo AB, Chouairi F, Kundishora AJ, Camara-Quintana J, Qureshi T, Kolb L, Laurans M, Abbed K, Karikari IO. Reduced Influence of Affective Disorders on 6-Week and 3-Month Narcotic Refills After Primary Complex Spinal Fusions for Adult Deformity Correction: A Single-Institutional Study. World Neurosurgery 2019, 129: e311-e316. PMID: 31132486, DOI: 10.1016/j.wneu.2019.05.135.Peer-Reviewed Original ResearchConceptsPrimary complex spinal fusionComplex spinal fusionNarcotic refillsPain scoresSpinal fusionAffective disordersDeformity correctionNarcotic useDeformity patientsAD cohortPatient-reported pain scoresAdult spine deformity patientsAdult deformity correctionPostoperative pain scoresPostoperative complication ratePreoperative narcotic useHigher pain scoresSpinal deformity patientsSpine deformity patientsMajor academic institutionAmbulatory statusComplication ratePatient demographicsPrimary outcomePostoperative perception
2018
Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients.
Elsamadicy AA, Ren X, Kemeny H, Charalambous L, Sergesketter AR, Rahimpour S, Williamson T, Goodwin CR, Abd-El-Barr MM, Gottfried ON, Xie J, Lad SP. Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients. Neurosurgery 2018, 84: 758-767. PMID: 29893899, DOI: 10.1093/neuros/nyy215.Peer-Reviewed Original ResearchConceptsElective lumbar spine surgeryChronic obstructive pulmonary disorderLumbar spine surgeryNational Readmission DatabaseUnplanned hospital readmissionPatient risk factorsUnplanned readmissionHospital readmissionSpine surgeryDeficiency anemiaInsurance statusRisk factorsElective spinal surgeryUnplanned readmission rateObstructive pulmonary disorderMultivariate regression analysisPaucity of dataInpatient complicationsNational healthcare expendituresReadmission ratesDural tearPulmonary disordersIndependent associationPatient outcomesSpinal surgery
2017
Independent Association Between Preoperative Cognitive Status and Discharge Location After Surgery: A Strategy to Reduce Resource Use After Surgery for Deformity
Adogwa O, Elsamadicy AA, Sergesketter A, Vuong VD, Moreno J, Cheng J, Karikari IO, Bagley CA. Independent Association Between Preoperative Cognitive Status and Discharge Location After Surgery: A Strategy to Reduce Resource Use After Surgery for Deformity. World Neurosurgery 2017, 110: e67-e72. PMID: 29081391, DOI: 10.1016/j.wneu.2017.10.081.Peer-Reviewed Original ResearchConceptsNormal cognitive statusCognitive impairmentCognitive statusOlder patientsSLUMS scorePreoperative cognitive impairmentElective spinal surgeryPreoperative cognitive statusStandard deviation ageAdult degenerative scoliosisBaseline cognitive impairmentSevere cognitive impairmentMental status testsMild cognitive impairmentPostoperative lengthPreoperative scoresDeviation ageGeriatric patientsDegenerative scoliosisIndependent associationSpinal surgeryDeformity correctionPatientsSurgeryCognitive screeningProphylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases.
Adogwa O, Elsamadicy AA, Sergesketter A, Vuong VD, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases. Journal Of Neurosurgery Spine 2017, 27: 328-334. PMID: 28665245, DOI: 10.3171/2017.2.spine161310.Peer-Reviewed Original ResearchConceptsSurgical site infectionMean body mass indexIntraoperative vancomycin powderVancomycin powderWound infectionAdult patientsProphylactic useCases of SSIPatients' mean body mass indexMicrobiological patternDirect medical record reviewPostoperative surgical site infectionDuke University Medical CenterDeep wound infectionEmpirical antibiotic therapyHistory of diabetesAdverse clinical outcomesMedical record reviewConsecutive surgical casesDay of surgeryBody mass indexSpinal deformity surgeryUniversity Medical CenterRandomized control trialHealth care systemDepression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery.
Elsamadicy AA, Adogwa O, Lydon E, Sergesketter A, Kaakati R, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Depression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery. Journal Of Neurosurgery Spine 2017, 27: 209-214. PMID: 28574333, DOI: 10.3171/2017.4.spine161012.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAge FactorsComorbidityDecompression, SurgicalDeliriumDepressionElective Surgical ProceduresFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOperative TimePostoperative ComplicationsPrognosisRetrospective StudiesRisk FactorsSpinal CurvaturesSpinal FusionSpineConceptsElective spine surgeryMultivariate logistic regression analysisPostoperative deliriumIndependent risk factorPostoperative complication rateSpine surgeryLogistic regression analysisPatient demographicsComplication rateIndependent predictorsDeformity patientsRisk factorsDepression groupAffective disordersSuperficial surgical site infectionSignificant between-group differencesInferior surgical outcomesPostoperative delirium rateResults Patient demographicsInitial hospital stayProportion of patientsRate of complicationsSurgical site infectionUrinary tract infectionDeep vein thrombosisAssociation of Intraoperative Blood Transfusions on Postoperative Complications, 30-Day Readmission Rates, and 1-Year Patient-Reported Outcomes
Elsamadicy AA, Adogwa O, Vuong VD, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Association of Intraoperative Blood Transfusions on Postoperative Complications, 30-Day Readmission Rates, and 1-Year Patient-Reported Outcomes. Spine 2017, 42: 610-615. PMID: 28399073, DOI: 10.1097/brs.0000000000001803.Peer-Reviewed Original ResearchConceptsPerioperative allogeneic RBC transfusionAllogeneic RBC transfusionElective spine surgeryPostoperative complication rateReadmission ratesRBC transfusionSpine surgeryPostoperative complicationsComplication rateThirty-day hospital readmission ratesAllogeneic red blood cell transfusionRed blood cell transfusionMultivariate logistic regression analysisMultivariate logistic regression modelPatient-reported outcome instrumentsHigher perioperative complicationsPostoperative hemoglobin levelsIntraoperative blood transfusionBlood cell transfusionHospital readmission ratesMajor academic medical centerLogistic regression analysisAcademic medical centerQuality of careLogistic regression modelsImpact of Affective Disorders on Recovery of Baseline Function in Patients Undergoing Spinal Surgery: A Single Institution Study of 275 Patients
Nayar G, Elsamadicy AA, Zakare-Fagbamila R, Farquhar J, Gottfried ON. Impact of Affective Disorders on Recovery of Baseline Function in Patients Undergoing Spinal Surgery: A Single Institution Study of 275 Patients. World Neurosurgery 2017, 100: 69-73. PMID: 28057592, DOI: 10.1016/j.wneu.2016.12.098.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityDecompression, SurgicalElective Surgical ProceduresFemaleHumansLength of StayMaleMiddle AgedMood DisordersMultivariate AnalysisPatient ReadmissionPatient Reported Outcome MeasuresPostoperative ComplicationsProspective StudiesRecovery of FunctionRegression AnalysisRetrospective StudiesRisk FactorsSelf ReportSpineConceptsDecompressive spinal surgeryIndependent risk factorSpinal surgeryAffective disordersRisk factorsOutcome measuresBaseline functionPatient-reported outcome measuresPoor baseline qualitySpinal surgery patientsWorse postoperative outcomesSingle-institution studyMain outcome measuresSelf-reported recoveryRegression analysisMultivariate regression analysisMajor academic institutionBaseline demographicsPerioperative variablesPostoperative outcomesSurgery patientsMore smokersSurgical outcomesPostoperative expectationsControl cohort
2016
Racial Disparities in 30-Day Readmission Rates After Elective Spine Surgery
Adogwa O, Elsamadicy AA, Mehta AI, Cheng J, Bagley CA, Karikari IO. Racial Disparities in 30-Day Readmission Rates After Elective Spine Surgery. Spine 2016, 41: 1677-1682. PMID: 27054453, DOI: 10.1097/brs.0000000000001616.Peer-Reviewed Original ResearchConceptsElective spine surgerySpine surgeryReadmission ratesBlack patientsUnplanned readmissionIndependent predictorsWhite patientsOutcome measuresMultivariate logistic regression modelRacial disparitiesCauses of readmissionDays of dischargeRetrospective cohort reviewRisk-adjusted oddsHigher readmission ratesBody mass indexPost-discharge careMain outcome measuresMultivariate logistic regressionMajor academic medical centerAcademic medical centerLogistic regression modelsHospital stayNonsurgical complicationsBaseline characteristics
2015
Pretreatment of Depression Before Cervical Spine Surgery Improves Patients' Perception of Postoperative Health Status: A Retrospective, Single Institutional Experience
Elsamadicy AA, Adogwa O, Cheng J, Bagley C. Pretreatment of Depression Before Cervical Spine Surgery Improves Patients' Perception of Postoperative Health Status: A Retrospective, Single Institutional Experience. World Neurosurgery 2015, 87: 214-219. PMID: 26706296, DOI: 10.1016/j.wneu.2015.11.067.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidepressive AgentsCervical VertebraeCohort StudiesDepressionDisability EvaluationDiskectomyFemaleHealth StatusHumansMaleMiddle AgedNeck PainPain MeasurementPatient SatisfactionPostoperative ComplicationsProspective StudiesRetrospective StudiesSpinal FusionSpineTreatment OutcomeConceptsNeck pain visual analog scalePain visual analog scaleNeck Disability IndexVisual analog scaleSF-12 mental component scoreSF-12 PCSMental component scoreSF-12 physical component scoreComponent scoresDuke University Medical CenterPatient-reported outcome measuresPostoperative health statusAnterior cervical discectomyCervical spine surgeryNerve root injurySingle institutional experiencePhysical component scoreShort Form-12Clinical outcome dataBoard-certified psychiatristHistory of depressionUniversity Medical CenterSimilar improvementsSignificant differencesDisability Index