Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile spine and sacrum.
Pennington Z, Ehresman J, Elsamadicy AA, Shin JH, Goodwin CR, Schwab JH, Sciubba DM. Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile spine and sacrum. Neurosurgical FOCUS 2021, 50: e17. PMID: 33932924, DOI: 10.3171/2021.2.focus201059.Peer-Reviewed Original ResearchConceptsDisease-free survivalProgression-free survivalDisease-specific survivalOverall survivalLocal controlMobile spineLong-term local controlAcute toxicityManagement of sarcomasEn bloc resectionCharged-particle therapyUse of protonsFull-text screeningDefinitive radiotherapyAdjuvant radiationDefinitive radiationSurgical cohortSurgical groupPrimary sarcomaUnresectable tumorsBloc resectionNegative marginsRadiation toxicityConventional radiotherapyHigh riskHypermutated phenotype in gliosarcoma of the spinal cord
Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. Npj Precision Oncology 2021, 5: 8. PMID: 33580181, PMCID: PMC7881101, DOI: 10.1038/s41698-021-00143-w.Peer-Reviewed Original ResearchSpinal cordWhole-exome sequencingLow-grade brain gliomasVariant of glioblastomaLow-grade gliomasTumor anteriorAdjuvant radiationNeurological deficitsSomatic single nucleotide variationsPoor prognosisGrade gliomasTemozolomide treatmentBrain gliomasGliosarcomaMicrosatellite stabilityCordSomatic mutationsHypermutator phenotypeGliomasComprehensive genetic characterizationGenomic mechanismsSingle nucleotide variationsPhenotypeFirst reportPathway genes