2021
Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortaAortic ValveBioprosthesisCardiomyopathy, HypertrophicEchocardiographyFemaleHumansHyperplasiaMaleMiddle AgedConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thicknessCharacteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy
Alashi A, Smedira NG, Popovic ZB, Fava A, Thamilarasan M, Kapadia SR, Wierup P, Lever HM, Desai MY. Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy. Journal Of The American Heart Association 2021, 10: e018527. PMID: 33506683, PMCID: PMC7955450, DOI: 10.1161/jaha.120.018527.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tract gradientVentricular outflow tract gradientOutflow tract gradientElderly patientsHypertrophic cardiomyopathyTract gradientObstructive subgroupRisk factorsDynamic left ventricular outflow tract obstructionSudden cardiac death risk factorsLeft ventricular outflow tract obstructionAppropriate internal defibrillator dischargeVentricular outflow tract obstructionBasal septal thicknessConclusion Elderly patientsDeath risk factorsSeptal reduction therapyThoracic Surgeons scoreConsecutive elderly patientsOutflow tract obstructionVentricular mass indexBasal septal hypertrophyLong-term outcomesHospital deathTract obstruction
2020
Characteristics and Longer-Term Outcomes of Contemporary Patients <18 Years of Age With Hypertrophic Cardiomyopathy
Alashi A, Svensson L, Klein J, Zahka K, Smedira NG, Najm H, Lever HM, Aziz P, Desai MY. Characteristics and Longer-Term Outcomes of Contemporary Patients <18 Years of Age With Hypertrophic Cardiomyopathy. The American Journal Of Cardiology 2020, 140: 110-117. PMID: 33159906, DOI: 10.1016/j.amjcard.2020.10.060.Peer-Reviewed Original ResearchConceptsOrthotopic heart transplantPrimary composite eventsSudden cardiac deathPresence of symptomsZ-scoreFractional shorteningAppropriate internal defibrillator dischargeVentricular outflow tract gradientLeft ventricular wall thicknessLV septal thicknessOutflow tract gradientPrimary composite outcomeAppropriate ICD dischargeComposite primary endpointLV fractional shorteningVentricular wall thicknessHypertrophic cardiomyopathy patientsYears of ageComposite eventsTract gradientHospital deathPrimary endpointComposite outcomeExperienced centersPHC patientsCharacteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function
Alashi A, Isaza N, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function. Journal Of The American Heart Association 2020, 9: e016537. PMID: 32755253, PMCID: PMC7660826, DOI: 10.1161/jaha.120.016537.Peer-Reviewed Original ResearchConceptsBaseline LV ejection fractionLV ejection fractionIncremental prognostic valueLV-GLSTakotsubo syndromePrognostic valueLower baseline LV ejection fractionObstructive coronary artery diseaseVentricular global longitudinal strainMultivariate Cox survival analysisMean LV ejection fractionWorse LV-GLSOutcomes of patientsPrimary end pointVentricular systolic functionCoronary artery diseaseGlobal longitudinal strainLong-term outcomesCox survival analysisPhysical triggersPrognostic cutoffCause mortalityApical ballooningConclusions PatientsSystolic function
2019
Long-Term Outcomes After Aortic Valve Surgery in Patients With Asymptomatic Chronic Aortic Regurgitation and Preserved LVEF Impact of Baseline and Follow-Up Global Longitudinal Strain
Alashi A, Khullar T, Mentias A, Gillinov AM, Roselli EE, Svensson LG, Popovic ZB, Griffin BP, Desai MY. Long-Term Outcomes After Aortic Valve Surgery in Patients With Asymptomatic Chronic Aortic Regurgitation and Preserved LVEF Impact of Baseline and Follow-Up Global Longitudinal Strain. JACC Cardiovascular Imaging 2019, 13: 12-21. PMID: 30772216, DOI: 10.1016/j.jcmg.2018.12.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic ValveAortic Valve InsufficiencyAsymptomatic DiseasesChronic DiseaseEchocardiographyFemaleHeart Valve Prosthesis ImplantationHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionLV-GLS valuesChronic aortic regurgitationAortic valve surgeryAortic regurgitationGlobal longitudinal strainAV surgeryLV-GLSValve surgeryMean left ventricular ejection fractionAsymptomatic chronic aortic regurgitationChronic severe aortic regurgitationVentricular global longitudinal strainBetter long-term survivalHigher long-term mortalityLongitudinal strainPost-operative echocardiographySevere aortic regurgitationLong-term mortalityVentricular ejection fractionSubgroup of patientsLong-term survivalSubgroup of subjectsAV replacementBaseline echocardiography
2018
Surgical management of left ventricular outflow tract obstruction in a specialized hypertrophic obstructive cardiomyopathy center
Hodges K, Rivas CG, Aguilera J, Borden R, Alashi A, Blackstone EH, Desai MY, Smedira NG. Surgical management of left ventricular outflow tract obstruction in a specialized hypertrophic obstructive cardiomyopathy center. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 2289-2299. PMID: 30782406, DOI: 10.1016/j.jtcvs.2018.11.148.Peer-Reviewed Original ResearchConceptsVentricular outflow tract obstructionOutflow tract obstructionMitral valve interventionLeft ventricular outflow tract obstructionTract obstructionSeptal myectomyValve interventionMitral interventionPostoperative ventricular septal defectContemporary surgical outcomesHypertrophic cardiomyopathy centersPapillary muscle resectionMitral valve replacementPermanent pacemaker insertionComplete heart blockMitral valve pathologyVentricular septal defectHospital outcomesOperative mortalityConcomitant proceduresValve replacementMuscle resectionSingle surgeonHeart blockRetrospective reviewRate of Progression of Aortic Stenosis and its Impact on Outcomes in Patients With Radiation-Associated Cardiac Disease A Matched Cohort Study
Donnellan E, Griffin BP, Johnston DR, Popovic ZB, Alashi A, Kapadia SR, Tuzcu EM, Krishnaswamy A, Mick S, Svensson LG, Desai MY. Rate of Progression of Aortic Stenosis and its Impact on Outcomes in Patients With Radiation-Associated Cardiac Disease A Matched Cohort Study. JACC Cardiovascular Imaging 2018, 11: 1072-1080. PMID: 29909108, DOI: 10.1016/j.jcmg.2018.04.019.Peer-Reviewed Original ResearchConceptsAortic valve replacementLong-term mortalityModerate aortic stenosisAortic stenosisRate of progressionPrior XRTLong-term survivalXRT groupHigher long-term mortalityAortic valve gradientMatched Cohort StudyComparison groupBasis of ageMediastinal radiotherapyCause mortalityValve gradientCohort studyValve replacementMore patientsXRT patientsPatientsHigh mortalityMortalityPrior exposureProgressionNovel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement
Huded CP, Kusunose K, Shahid F, Goodman AL, Alashi A, Grimm RA, Gillinov AM, Johnston DR, Rodriguez LL, Popovic ZB, Sato K, Svensson LG, Griffin BP, Desai MY. Novel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement. The American Journal Of Cardiology 2018, 122: 284-293. PMID: 29751954, DOI: 10.1016/j.amjcard.2018.03.359.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLeft ventricular ejection fractionAortic valve replacementSevere aortic stenosisLV-GLSAortic stenosisSTS scoreValve replacementVentricular stroke volume indexVentricular global longitudinal strainLeft ventricular systolic functionMultivariate Cox survival analysisValidation subgroupNovel echocardiographic parametersThoracic Surgeons scoreWorse LV-GLSStroke volume indexVentricular systolic functionVentricular ejection fractionGlobal longitudinal strainCox survival analysisHigher STS scoreLong-term survivalIncremental prognostic impactDerivation subgroup
2016
Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Primary Mitral Regurgitation and Preserved Systolic Function Undergoing Mitral Valve Surgery
Alashi A, Mentias A, Patel K, Gillinov AM, Sabik JF, Popović ZB, Mihaljevic T, Suri RM, Rodriguez LL, Svensson LG, Griffin BP, Desai MY. Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Primary Mitral Regurgitation and Preserved Systolic Function Undergoing Mitral Valve Surgery. Circulation Cardiovascular Imaging 2016, 9: e004451. PMID: 27342145, DOI: 10.1161/circimaging.115.004451.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesBiomarkersCardiac Surgical ProceduresChi-Square DistributionEchocardiographyFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMultivariate AnalysisMyocardial ContractionNatriuretic Peptide, BrainPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsTreatment OutcomeVentricular Function, LeftVentricular Function, RightVentricular PressureConceptsLeft ventricular ejection fractionMitral valve surgeryVentricular ejection fractionLog-transformed BNPThoracic Surgeons scoreBrain natriuretic peptidePrimary mitral regurgitationRight ventricular systolic pressureSignificant primary mitral regurgitationVentricular systolic pressureGlobal longitudinal strainIncremental prognostic utilityLV-GLSAsymptomatic patientsValve surgeryEjection fractionMitral regurgitationSurgeons scoreNatriuretic peptideSystolic pressurePrognostic utilityBaseline LV global longitudinal strainBaseline right ventricular systolic pressureMitral effective regurgitant orificeLV global longitudinal strain