2021
Predictive value of NT-proBNP in non-obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Fava A, Popovic Z, Thamilarasan M, Lever H, Desai M. Predictive value of NT-proBNP in non-obstructive hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0765. DOI: 10.1093/eurheartj/ehab724.0765.Peer-Reviewed Original ResearchNT-proBNP ratioLV ejection fractionSerum NT-proBNPNT-proBNPAsymptomatic patientsPrimary endpointSeptal myectomySudden cardiac death risk factorsNon-obstructive hypertrophic cardiomyopathyKaplan-Meier survival analysisDeath risk factorsEarly disease stagesHypertrophic cardiomyopathy patientsImplantable defibrillator dischargesEjection fractionHeart transplantPrimary outcomeRisk stratificationPrognostic valueAdverse outcomesDisease stageCardiomyopathy patientsRisk factorsEcho variablesHypertrophic cardiomyopathyOutcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thicknessCharacteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy
Alashi A, Smedira NG, Popovic ZB, Fava A, Thamilarasan M, Kapadia SR, Wierup P, Lever HM, Desai MY. Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy. Journal Of The American Heart Association 2021, 10: e018527. PMID: 33506683, PMCID: PMC7955450, DOI: 10.1161/jaha.120.018527.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tract gradientVentricular outflow tract gradientOutflow tract gradientElderly patientsHypertrophic cardiomyopathyTract gradientObstructive subgroupRisk factorsDynamic left ventricular outflow tract obstructionSudden cardiac death risk factorsLeft ventricular outflow tract obstructionAppropriate internal defibrillator dischargeVentricular outflow tract obstructionBasal septal thicknessConclusion Elderly patientsDeath risk factorsSeptal reduction therapyThoracic Surgeons scoreConsecutive elderly patientsOutflow tract obstructionVentricular mass indexBasal septal hypertrophyLong-term outcomesHospital deathTract obstruction
2020
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017
Yadgir S, Johnson CO, Aboyans V, Adebayo OM, Adedoyin RA, Afarideh M, Alahdab F, Alashi A, Alipour V, Arabloo J, Azari S, Barthelemy CM, Benziger CP, Berman AE, Bijani A, Carrero JJ, Carvalho F, Daryani A, Durães AR, Esteghamati A, Farid TA, Farzadfar F, Fernandes E, Filip I, Gad MM, Hamidi S, Hay SI, Ilesanmi OS, Irvani S, Jürisson M, Kasaeian A, Kengne AP, Khan AR, Kisa A, Kisa S, Kolte D, Manafi N, Manafi A, Mensah GA, Mirrakhimov EM, Mohammad Y, Mokdad AH, Negoi RI, Nguyen H, Nguyen TH, Nixon MR, Otto CM, Patel S, Pilgrim T, Radfar A, Rawaf DL, Rawaf S, Rawasia WF, Rezapour A, Roever L, Saad AM, Saadatagah S, Senthilkumaran S, Sliwa K, Tesfay BE, Tran BX, Ullah I, Vaduganathan M, Vasankari TJ, Wolfe CDA, Yonemoto N, Roth GA. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017. Circulation 2020, 141: 1670-1680. PMID: 32223336, DOI: 10.1161/circulationaha.119.043391.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAortic ValveAortic Valve InsufficiencyAortic Valve StenosisCalcinosisCost of IllnessFemaleGlobal HealthHealth Status DisparitiesHealthcare DisparitiesHumansMaleMitral Valve InsufficiencyMitral Valve ProlapsePrevalenceQuality of LifeRisk AssessmentRisk FactorsTime FactorsConceptsCalcific aortic valve diseaseDegenerative mitral valve diseaseMitral valve diseaseValve diseaseValvular diseaseNational burdenDisease burdenGlobal burdenAge-standardized DALY ratesHigher age-standardized DALY ratesModifiable risk factorsAortic valve diseaseCalcific aortic valvesDisease Study 2017Number of DALYsAdministrative hospital dataHealth-related burdenEpidemiologic survey dataDALY ratesValve repairTreatable diseaseAortic valveRisk factorsOverall burdenPrevalent cases