2021
Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thickness
2020
Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function
Alashi A, Isaza N, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function. Journal Of The American Heart Association 2020, 9: e016537. PMID: 32755253, PMCID: PMC7660826, DOI: 10.1161/jaha.120.016537.Peer-Reviewed Original ResearchConceptsBaseline LV ejection fractionLV ejection fractionIncremental prognostic valueLV-GLSTakotsubo syndromePrognostic valueLower baseline LV ejection fractionObstructive coronary artery diseaseVentricular global longitudinal strainMultivariate Cox survival analysisMean LV ejection fractionWorse LV-GLSOutcomes of patientsPrimary end pointVentricular systolic functionCoronary artery diseaseGlobal longitudinal strainLong-term outcomesCox survival analysisPhysical triggersPrognostic cutoffCause mortalityApical ballooningConclusions PatientsSystolic function
2018
Novel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement
Huded CP, Kusunose K, Shahid F, Goodman AL, Alashi A, Grimm RA, Gillinov AM, Johnston DR, Rodriguez LL, Popovic ZB, Sato K, Svensson LG, Griffin BP, Desai MY. Novel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement. The American Journal Of Cardiology 2018, 122: 284-293. PMID: 29751954, DOI: 10.1016/j.amjcard.2018.03.359.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLeft ventricular ejection fractionAortic valve replacementSevere aortic stenosisLV-GLSAortic stenosisSTS scoreValve replacementVentricular stroke volume indexVentricular global longitudinal strainLeft ventricular systolic functionMultivariate Cox survival analysisValidation subgroupNovel echocardiographic parametersThoracic Surgeons scoreWorse LV-GLSStroke volume indexVentricular systolic functionVentricular ejection fractionGlobal longitudinal strainCox survival analysisHigher STS scoreLong-term survivalIncremental prognostic impactDerivation subgroup
2016
Long-Term Outcomes in Patients With Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
Mentias A, Feng K, Alashi A, Rodriguez LL, Gillinov AM, Johnston DR, Sabik JF, Svensson LG, Grimm RA, Griffin BP, Desai MY. Long-Term Outcomes in Patients With Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. Journal Of The American College Of Cardiology 2016, 68: 2144-2153. PMID: 27855803, DOI: 10.1016/j.jacc.2016.08.045.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionAV surgeryVentricular ejection fractionAortic regurgitationLong-term survivalEjection fractionSuch patientsLeft ventricleChronic severe aortic regurgitationSex-matched U.S. populationLV end-systolic dimensionMultivariate Cox survival analysisGreater aortic regurgitationHospital postoperative mortalityMean STS scoreThoracic Surgeons scoreAortic valve surgeryChronic aortic regurgitationSevere aortic regurgitationEnd-systolic dimensionSurvival of patientsLong-term outcomesRisk of deathCox survival analysisPostoperative mortality