2021
Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thickness
2018
Rate of Progression of Aortic Stenosis and its Impact on Outcomes in Patients With Radiation-Associated Cardiac Disease A Matched Cohort Study
Donnellan E, Griffin BP, Johnston DR, Popovic ZB, Alashi A, Kapadia SR, Tuzcu EM, Krishnaswamy A, Mick S, Svensson LG, Desai MY. Rate of Progression of Aortic Stenosis and its Impact on Outcomes in Patients With Radiation-Associated Cardiac Disease A Matched Cohort Study. JACC Cardiovascular Imaging 2018, 11: 1072-1080. PMID: 29909108, DOI: 10.1016/j.jcmg.2018.04.019.Peer-Reviewed Original ResearchConceptsAortic valve replacementLong-term mortalityModerate aortic stenosisAortic stenosisRate of progressionPrior XRTLong-term survivalXRT groupHigher long-term mortalityAortic valve gradientMatched Cohort StudyComparison groupBasis of ageMediastinal radiotherapyCause mortalityValve gradientCohort studyValve replacementMore patientsXRT patientsPatientsHigh mortalityMortalityPrior exposureProgressionNovel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement
Huded CP, Kusunose K, Shahid F, Goodman AL, Alashi A, Grimm RA, Gillinov AM, Johnston DR, Rodriguez LL, Popovic ZB, Sato K, Svensson LG, Griffin BP, Desai MY. Novel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement. The American Journal Of Cardiology 2018, 122: 284-293. PMID: 29751954, DOI: 10.1016/j.amjcard.2018.03.359.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLeft ventricular ejection fractionAortic valve replacementSevere aortic stenosisLV-GLSAortic stenosisSTS scoreValve replacementVentricular stroke volume indexVentricular global longitudinal strainLeft ventricular systolic functionMultivariate Cox survival analysisValidation subgroupNovel echocardiographic parametersThoracic Surgeons scoreWorse LV-GLSStroke volume indexVentricular systolic functionVentricular ejection fractionGlobal longitudinal strainCox survival analysisHigher STS scoreLong-term survivalIncremental prognostic impactDerivation subgroup
2017
Aortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta
Masri A, Kalahasti V, Svensson LG, Alashi A, Schoenhagen P, Roselli EE, Johnston DR, Rodriguez LL, Griffin BP, Desai MY. Aortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta. Circulation Cardiovascular Imaging 2017, 10: e006249. PMID: 28592593, DOI: 10.1161/circimaging.116.006249.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnatomic LandmarksAortaAortic AneurysmAortic ValveAortographyBicuspid Aortic Valve DiseaseCause of DeathChi-Square DistributionComputed Tomography AngiographyDilatation, PathologicFemaleHeart Valve DiseasesHospital MortalityHumansKaplan-Meier EstimateMagnetic Resonance AngiographyMaleMiddle AgedMultidetector Computed TomographyMultivariate AnalysisOhioPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBicuspid aortic valve patientsProximal ascending aortaAortic valve patientsBicuspid aortic valveAortic areaCardiovascular deathAscending aortaAortic surgeryValve patientsAortic valveMultivariable Cox survival analysisRight ventricular systolic pressureLong-term cardiovascular mortalityContrast-enhanced thoracicThoracic Surgeons scoreSevere aortic stenosisVentricular systolic pressureCox survival analysisMagnetic resonance angiographyHeight ratioAortic regurgitationCardiovascular mortalitySurgeons scoreAortic stenosisImproved survival