2022
UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
Kim DJ, Iwasaki A, Chien AL, Kang S. UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner. JCI Insight 2022, 7: e156344. PMID: 35316219, PMCID: PMC9090247, DOI: 10.1172/jci.insight.156344.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA DamageMatrix Metalloproteinase 2Matrix MetalloproteinasesMiceReactive Oxygen SpeciesReceptors, Aryl HydrocarbonSkin AgingConceptsSpecificity protein 1DNA damageSp1-dependent mannerProtein 1Activator protein-1HaCaT human immortalized keratinocytesExtracellular matrix componentsTranscription factorsAryl hydrocarbon receptorHuman immortalized keratinocytesMatrix componentsHydrocarbon receptorPotential targetImmortalized keratinocytesROSSun-exposed skinType IV collagenMMP2 expressionAhRMatrix metalloproteinasesMechanistic studiesMMP2IV collagenTopical treatmentMMP-1
2009
Autophagic control of RLR signaling
Tal MC, Iwasaki A. Autophagic control of RLR signaling. Autophagy 2009, 5: 749-750. PMID: 19571662, PMCID: PMC3693554, DOI: 10.4161/auto.5.5.8789.Peer-Reviewed Original ResearchMeSH KeywordsAutophagyHumansInflammationMitochondriaModels, BiologicalReactive Oxygen SpeciesReceptors, Cell SurfaceSignal TransductionConceptsAbsence of autophagyReactive oxygen speciesPattern recognition receptorsRetinoic acid-inducible gene IAcid-inducible gene IATG5 knockout cellsImportance of autophagyInducible gene IPotent antiviral factorsLike receptor familyI interferonCytosolic signalingKnockout cellsCellular organellesAutophagy functionAutophagic controlGene IRNA virusesAutophagyReceptor familyType I interferonMitochondriaAntiviral factorsRecognition receptorsInfected cellsAbsence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 2770-2775. PMID: 19196953, PMCID: PMC2650341, DOI: 10.1073/pnas.0807694106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyAutophagy-Related Protein 5Cells, CulturedDEAD Box Protein 58DEAD-box RNA HelicasesDNA, MitochondrialEnzyme-Linked Immunosorbent AssayFlow CytometryInterferon Type IMacrophagesMiceMicrotubule-Associated ProteinsMitochondriaReactive Oxygen SpeciesReverse Transcriptase Polymerase Chain ReactionSignal TransductionConceptsReactive oxygen speciesDysfunctional mitochondriaInnate antiviral defenseAntiviral defenseKey antiviral cytokinesAbsence of autophagyMitochondrial reactive oxygen speciesHomeostatic regulationRole of autophagyTreatment of cellsIPS-1RLR signalingVesicular stomatitis virusAutophagy resultsRNA virusesWT cellsMitochondriaAutophagyType I IFNStomatitis virusRLRLike receptorsOxygen speciesNeurodegenerative diseasesInflammatory disordersInflammasomes in viral infection
Ichinohe T, Iwasaki A. Inflammasomes in viral infection. Uirusu 2009, 59: 13. PMID: 19927984, DOI: 10.2222/jsv.59.13.Peer-Reviewed Original ResearchConceptsNOD-like receptorsProinflammatory cytokine interleukin-1betaRole of inflammasomesInfluenza virus infectionCytokine interleukin-1betaInnate immune responseCaspase-1 activationIL-33IL-18NLRP3 inflammasomeVirus infectionImmune responseInterleukin-1betaAdaptive immunityInflammasome activationMicrobial motifsDamage-associated signalsViral infectionInflammasomeMultiprotein complexesAdaptor proteinInfectionCertain virusesCell deathIntracellular sensors