2017
Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice
Gibb DR, Liu J, Natarajan P, Santhanakrishnan M, Madrid DJ, Eisenbarth SC, Zimring JC, Iwasaki A, Hendrickson JE. Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice. The Journal Of Immunology 2017, 199: 1041-1050. PMID: 28630094, PMCID: PMC5568771, DOI: 10.4049/jimmunol.1700401.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRed blood cell alloimmunizationCertain inflammatory disordersCompatible blood productsProduction of alloantibodiesHemolytic transfusion reactionsCytosolic pattern recognition receptorsType I IFNsTransgenic murine modelType I IFNPattern recognition receptorsTransfusion protocolAlloimmune responseRBC transfusionInflammatory disordersInflammatory conditionsTransfusion reactionsBlood productsInflammatory stimuliMurine modelI IFNsAlloimmunizationI IFNViral infectionRecognition receptors
2010
Regulation of Adaptive Immunity by the Innate Immune System
Iwasaki A, Medzhitov R. Regulation of Adaptive Immunity by the Innate Immune System. Science 2010, 327: 291-295. PMID: 20075244, PMCID: PMC3645875, DOI: 10.1126/science.1183021.Peer-Reviewed Original ResearchConceptsInnate immune recognitionB lymphocyte-mediated immune responsesImmune responsePattern recognition receptorsImmune recognitionAntigen-specific adaptive immune responsesLymphocyte-mediated immune responsesMicrobial pathogensInnate immune systemAdaptive immune responsesRecognition receptorsHost defenseField of immunologyAdaptive immunityImmune systemFundamental questionsReceptorsRegulationPathwayPathogensInvasionDefenseInjuryInfectionDiscovery
2009
Autophagy and Innate Recognition Systems
Tal MC, Iwasaki A. Autophagy and Innate Recognition Systems. Current Topics In Microbiology And Immunology 2009, 335: 107-121. PMID: 19802562, DOI: 10.1007/978-3-642-00302-8_5.Peer-Reviewed Original ResearchConceptsAutophagic machineryInnate immune systemDouble-membrane structureViral replication complexProcess of autophagyImportant physiological processesInduction of autophagyInnate recognition systemsCellular homeostasisReplication complexPattern recognition receptorsAutophagy pathwayLysosomal degradationPhysiological processesCytosolic constituentsEfficient phagocytosisInnate pattern recognition receptorsRNA virusesAutophagyCytosolic sensorsKey moleculesExtracellular pathogensRecognition receptorsImmune systemViral sensorsAutophagic control of RLR signaling
Tal MC, Iwasaki A. Autophagic control of RLR signaling. Autophagy 2009, 5: 749-750. PMID: 19571662, PMCID: PMC3693554, DOI: 10.4161/auto.5.5.8789.Peer-Reviewed Original ResearchConceptsAbsence of autophagyReactive oxygen speciesPattern recognition receptorsRetinoic acid-inducible gene IAcid-inducible gene IATG5 knockout cellsImportance of autophagyInducible gene IPotent antiviral factorsLike receptor familyI interferonCytosolic signalingKnockout cellsCellular organellesAutophagy functionAutophagic controlGene IRNA virusesAutophagyReceptor familyType I interferonMitochondriaAntiviral factorsRecognition receptorsInfected cells
2004
Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
Sato A, Iwasaki A. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16274-16279. PMID: 15534227, PMCID: PMC528964, DOI: 10.1073/pnas.0406268101.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationCaspase 1Cell DifferentiationCell MovementDendritic CellsFemaleHerpesvirus 2, HumanImmunity, InnateInterleukin-12Membrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicReceptors, InterferonSignal TransductionStromal CellsTh1 CellsToll-Like ReceptorsConceptsToll-like receptorsT cell responsesPattern recognition receptorsViral infectionContribution of TLRsRecognition receptorsCell responsesEffector T cell responsesHerpes simplex virus type 2Simplex virus type 2Antiviral adaptive immunityDendritic cell compartmentEffector T cellsDendritic cell maturationMost viral infectionsVirus type 2Infected epithelial cellsMucosal infectionsT cellsAdaptive immunityAntiviral immunityInfectious agentsType 2Immune recognitionStromal cells