2021
Perioperative thrombocytopenia
Lombard FW, Popescu WM, Oprea AD, Kertai MD. Perioperative thrombocytopenia. Current Opinion In Anaesthesiology 2021, 34: 335-344. PMID: 33935182, DOI: 10.1097/aco.0000000000000999.Peer-Reviewed Original ResearchConceptsPlatelet countThrombopoietin receptor agonistsRisk of bleedingProphylactic platelet transfusionsProthrombin complex concentrateRecombinant factor VIIGood quality evidenceThreshold platelet countIntravenous immunoglobulinPreoperative thrombocytopeniaAsymptomatic patientsPerioperative strategiesPerioperative managementSevere bleedingAntifibrinolytic agentsPlatelet transfusionsComplex concentrateQuality evidenceFibrinogen levelsReceptor agonistPerioperative thrombocytopeniaPlatelet functionThrombin generationIntraoperative alternativeFactor VII
2020
Periprocedural management of patients on oral anticoagulation: focus on regional anesthesia.
Li J, Oprea AD. Periprocedural management of patients on oral anticoagulation: focus on regional anesthesia. Polish Archives Of Internal Medicine 2020, 130: 1081-1092. PMID: 32491305, DOI: 10.20452/pamw.15416.Peer-Reviewed Original ResearchConceptsRegional anesthesia proceduresOral anticoagulantsAnesthesia proceduresPermanent neuronal damageBlood loss volumePeripheral nerve blocksOperating room proceduresNoncompressible areasOral anticoagulationPeriprocedural managementAnticoagulant medicationNeuronal damageNerve blockNeuraxial anesthesiaDeep plexusThrombotic riskCurrent guidelinesRegional anesthesiaLoss volumeRoom proceduresStandardized usePatientsAnesthesiaAnticoagulantsPatient anatomyUpdates in periprocedural management of direct oral anticoagulants.
Tao J, Oprea AD. Updates in periprocedural management of direct oral anticoagulants. Current Opinion In Anaesthesiology 2020, 33: 423-431. PMID: 32371643, DOI: 10.1097/aco.0000000000000873.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsPeriprocedural managementOral anticoagulantsPrevalence of patientsDrug interruptionTrough levelsComplete clearanceProcedural riskPartial clearanceClinical riskAmerican CollegeElectrophysiology proceduresFavorable pharmacokineticsQuick onsetAnticoagulantsRiskClearanceDrugsReview detailsBleedingMedicationsManagementPatientsAntithromboticsAnesthesiologists
2019
Periprocedural Anticoagulation Management For Nonoperating Room Anesthesia Procedures: A Clinical Guide
Tao J, Oprea AD. Periprocedural Anticoagulation Management For Nonoperating Room Anesthesia Procedures: A Clinical Guide. Seminars In Cardiothoracic And Vascular Anesthesia 2019, 23: 352-368. PMID: 31431127, DOI: 10.1177/1089253219870627.Peer-Reviewed Original ResearchConceptsOral anticoagulantsChronic oral anticoagulationPeriprocedural anticoagulation managementRoom anesthesiaNonoperating room anesthesiaNon-operating room proceduresOral anticoagulationPeriprocedural managementAnticoagulation managementClinical guideTraditional surgeryNon-operating room anesthesiaSafe careRoom proceduresAnesthesiaAnticoagulantsRiskManagement optionsAnticoagulationPatientsSurgeryUnique challengesAnesthesiologistsPharmacokineticsManagement
2016
Risk stratification, perioperative and periprocedural management of the patient receiving anticoagulant therapy
Oprea AD, Noto CJ, Halaszynski TM. Risk stratification, perioperative and periprocedural management of the patient receiving anticoagulant therapy. Journal Of Clinical Anesthesia 2016, 34: 586-599. PMID: 27687455, DOI: 10.1016/j.jclinane.2016.06.016.Peer-Reviewed Original ResearchConceptsPeriprocedural managementPerioperative periodInterventional pain proceduresRandomized clinical trialsAntithrombotic therapyAnticoagulant therapyPerioperative managementThromboembolic complicationsCoronary diseaseRisk stratificationAtrial fibrillationOutpatient settingPain proceduresClinical trialsRegional anesthesiaClinical judgmentUS populationTherapeutic useTime pointsAnticoagulantsTherapySubsequent increaseSpecial considerationAnticoagulationComplications
2013
ADP-Receptor Inhibitors in the Perioperative Period: The Good, the Bad, and the Ugly
Oprea AD, Popescu WM. ADP-Receptor Inhibitors in the Perioperative Period: The Good, the Bad, and the Ugly. Journal Of Cardiothoracic And Vascular Anesthesia 2013, 27: 779-795. PMID: 23648080, DOI: 10.1053/j.jvca.2012.11.014.Peer-Reviewed Original ResearchAdenosineCardiac Surgical ProceduresClopidogrelHemorrhageHumansPerioperative CarePiperazinesPlatelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Receptors, Purinergic P2Y12Surgical Procedures, OperativeThiophenesTicagrelorTiclopidineTreatment Outcome