Featured Publications
Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regionsBeyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions
Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.Peer-Reviewed Original ResearchConceptsLong-term seizure freedomSeizure freedomSeizure frequencyElectrode implantationIntracranial studiesLong-term seizure reductionAdditional surgical interventionSeizure onset localizationIntracranial electroencephalogram monitoringSeizure reductionConsecutive patientsSurgical interventionEpileptogenic networksElectroencephalogram monitoringNeuromodulatory effectsRetrospective analysisIntracranial monitoringTransient improvementDepth electrodesPatientsYear 4ImplantationAdequate dataYearsInvasive EEG in presurgical evaluation of epilepsy
Spencer D, Nguyen D, Sivaraju A. Invasive EEG in presurgical evaluation of epilepsy. 2015, 733-755. DOI: 10.1002/9781118936979.ch58.Peer-Reviewed Original ResearchEpileptogenic lesionsMRI protocolEarly treatment optionEpilepsy surgical procedureNon-surgical candidatesCommon epileptogenic lesionsSpecific MRI protocolQuality of MRIEpilepsy surgeryMRI criteriaPresurgical evaluationTreatment optionsCerebral areasInvasive EEGSurgical proceduresNeurosurgical proceduresMR imagingMR spectroscopyLesionsEpilepsyTypical featuresImagingPatientsSurgeryPathology
2023
The International Cardiac Arrest Research Consortium Electroencephalography Database
Amorim E, Zheng W, Ghassemi M, Aghaeeaval M, Kandhare P, Karukonda V, Lee J, Herman S, Sivaraju A, Gaspard N, Hofmeijer J, van Putten M, Sameni R, Reyna M, Clifford G, Westover M. The International Cardiac Arrest Research Consortium Electroencephalography Database. Critical Care Medicine 2023, 51: 1802-1811. PMID: 37855659, PMCID: PMC10841086, DOI: 10.1097/ccm.0000000000006074.Peer-Reviewed Original ResearchConceptsCardiac arrestNeurologic outcomeCerebral Performance Category scaleContinuous electroencephalography monitoringGood functional recoverySevere neurologic disabilityIctal-interictal continuumIndividuals 16 yearsBrain injury researchCardiac arrest researchMost patientsNeurologic disabilityMulticenter cohortSpontaneous circulationComatose patientsFunctional recoveryEpileptiform activityElectroencephalography monitoringTeaching hospitalBackground continuityClinical dataBurst suppressionPatientsEpileptiform patternsSpike frequencyIntracranial Entrainment Reveals Statistical Learning across Levels of Abstraction
Sherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction. Journal Of Cognitive Neuroscience 2023, 35: 1312-1328. PMID: 37262357, DOI: 10.1162/jocn_a_02012.Peer-Reviewed Original ResearchImpact of acute symptomatic seizures and their management on patient-reported outcomes after stroke
Punia V, Li Y, Lapin B, Chandan P, Newey C, Hantus S, Dhakar M, Rubinos C, Zafar S, Sivaraju A, Katzan I, investigators F. Impact of acute symptomatic seizures and their management on patient-reported outcomes after stroke. Epilepsy & Behavior 2023, 140: 109115. PMID: 36804847, DOI: 10.1016/j.yebeh.2023.109115.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresAnti-seizure medicationsAcute symptomatic seizuresOutcome measuresSymptomatic seizuresHospital dischargeASM useExact testFirst patient-reported outcome measureRetrospective cohort studyPatient-reported outcomesStandard of careContinuous EEG monitoringFisher's exact testWilcoxon rank sum testChi-square testRank sum testPROM completionStroke clinicCohort studyRecent strokeStroke patientsNeuro-QoLPhysical functionPatients
2022
Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy
Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA. Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Journal Of Neurology Neurosurgery & Psychiatry 2022, 94: 245-249. PMID: 36241423, PMCID: PMC9931627, DOI: 10.1136/jnnp-2022-329542.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyTraumatic brain injuryCT abnormalitiesElectroencephalography featuresAdmission Glasgow Coma Scale scoreGlasgow Coma Scale scoreRetrospective case-control studyMultivariable logistic regression analysisRisk stratification modelCase-control studyLogistic regression analysisTBI admissionsSevere complicationsFuture trialsBrain injuryCT reportsSeizure diagnosisPredictive valueScale scorePatientsLogistic regressionStratification modelQuantitative electroencephalogramTBI mechanismsRegression analysisAcute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
Punia V, Ellison L, Bena J, Chandan P, Sivaraju A, George P, Newey CR, Hantus S. Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study. Annals Of Clinical And Translational Neurology 2022, 9: 558-563. PMID: 35243824, PMCID: PMC8994977, DOI: 10.1002/acn3.51534.Peer-Reviewed Original ResearchConceptsPost-stroke epilepsyDays of presentationMultivariable logistic modelCase-control studyContinuous EEG monitoringUnivariable analysisStroke patientsEpileptiform abnormalitiesSeizure managementPresence of EAEEG monitoringTherapy trialsEpilepsyPrimary predictorPredictorsLogistic modelPatientsAbnormalitiesTrials
2008
Increased beat-to-beat ‘R’ amplitude variability in patients with panic disorder
Yeragani V, Chokka P, Tancer M, Sivaraju A, Bar K. Increased beat-to-beat ‘R’ amplitude variability in patients with panic disorder. International Journal Of Cardiology 2008, 143: 431-432. PMID: 19097657, DOI: 10.1016/j.ijcard.2008.12.003.Peer-Reviewed Original Research