2023
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain EdemaBrain InjuriesBrain NeoplasmsCerebral HemorrhageDiffusion Magnetic Resonance ImagingEdemaHematomaHumansMiddle AgedPilot ProjectsConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2022
A comparison of simultaneous multislice and conventional diffusion tensor imaging techniques for ischemic stroke evaluation at 1.5T
Culleton S, Kolowori S, Roberts J, de Havenon A, DiBella E, McNally J. A comparison of simultaneous multislice and conventional diffusion tensor imaging techniques for ischemic stroke evaluation at 1.5T. British Journal Of Radiology 2022, 96: 20220222. PMID: 36469531, PMCID: PMC10997011, DOI: 10.1259/bjr.20220222.Peer-Reviewed Original ResearchMeSH KeywordsDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansIschemic StrokeReproducibility of ResultsSexually Transmitted DiseasesConceptsIschemic stroke evaluationStroke workupStroke evaluationMean diffusivityDiffusion tensorIschemic strokeStroke protocolAcute settingIschemic stroke detectionTreatment windowBlinded neuroradiologistsIRB approvalDiagnostic accuracyFractional anisotropyT MRIObserver 2Observer 1Interrater reliabilityT-testConventional diffusion tensorWorkupDTIAverage image qualityCharacteristic areaCoefficient of variation
2021
MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy
Muddasani V, de Havenon A, McNally JS, Baradaran H, Alexander MD. MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy. Topics In Magnetic Resonance Imaging 2021, 30: 197-204. PMID: 34397969, PMCID: PMC8371677, DOI: 10.1097/rmr.0000000000000277.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingPerfusionStrokeThrombectomyThrombolytic TherapyConceptsMagnetic resonance imagingIschemic strokeComputed tomographyMR perfusionCore infarctDiffusion-weighted magnetic resonance imagingPerfusion-diffusion mismatchDegree of ischemiaNoncontrast Computed TomographyImproved imaging techniquesSalvageable brainSuperior diagnostic informationIschemic penumbraSymptom onsetAcute evaluationAppropriate imagingPatient selectionStroke therapyThrombolytic therapyPoor outcomePrognostic valueLeading causeEffective treatmentBetter outcomesEarly identificationDifferentiation of symptomatic and asymptomatic carotid intraplaque hemorrhage using 3D high‐resolution diffusion‐weighted stack of stars imaging
Kim S, Parker D, Roberts J, Treiman G, Alexander M, Baradaran H, de Havenon A, McNally J. Differentiation of symptomatic and asymptomatic carotid intraplaque hemorrhage using 3D high‐resolution diffusion‐weighted stack of stars imaging. NMR In Biomedicine 2021, 34: e4582. PMID: 34296793, DOI: 10.1002/nbm.4582.Peer-Reviewed Original ResearchMeSH KeywordsCarotid StenosisComputer SimulationDiffusion Magnetic Resonance ImagingHemorrhageHumansImaging, Three-DimensionalPhantoms, ImagingSignal Processing, Computer-AssistedConceptsApparent diffusion coefficientCarotid diseaseApparent diffusion coefficient valuesDiffusion-weighted (DW) imagingApparent diffusion coefficient measurementsSymptomatic plaquesAsymptomatic plaquesInternal carotid artery plaqueWilcoxon-Mann-Whitney U testIntraplaque hemorrhageCarotid intraplaque hemorrhageCarotid artery plaquesElevated stroke riskAssociated with plaque instabilityImprove detectionSymptomatic statusHealthy subjectsQuantitative diffusion measurementsU testCarotid atherosclerosisArtery plaquesPlaque instabilityPhantom studyStroke riskHemorrhage
2018
Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection
McNally JS, Hinckley PJ, Sakata A, Eisenmenger LB, Kim SE, De Havenon AH, Quigley EP, Iacob E, Treiman GS, Parker DL. Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection. Stroke 2018, 49: 2337-2344. PMID: 30355108, PMCID: PMC6208137, DOI: 10.1161/strokeaha.118.021868.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArteriesBrain IschemiaDiffusion Magnetic Resonance ImagingFemaleHematomaHumansMagnetic Resonance AngiographyMaleMiddle AgedReproducibility of ResultsRetrospective StudiesStrokeConceptsAcute ischemic strokeCervical artery dissectionIntramural hematomaIschemic strokeArtery dissectionT1-weighted sequencesIMH detectionMagnetic resonance imaging/magnetic resonance angiographyGradient-recalled echoMethods Institutional review board approvalIschemic stroke pathogenesisCardiovascular risk factorsStroke sourcesInterrater reliabilityMultivariate Poisson regressionReview board approvalMagnetic resonance angiographyMagnetic resonance imagingStroke prediction modelsStroke pathogenesisAcute strokeCurrent smokingClinical factorsAtherosclerotic diseaseImaging findingsLow b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest
Peckham ME, Anderson JS, Rassner UA, Shah LM, Hinckley PJ, de Havenon A, Kim SE, McNally JS. Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest. Critical Care 2018, 22: 165. PMID: 29925413, PMCID: PMC6011248, DOI: 10.1186/s13054-018-2087-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain DeathDiffusion Magnetic Resonance ImagingFemaleHeart ArrestHumansMaleMiddle AgedRetrospective StudiesConceptsHypoxic-ischemic encephalopathyBrain deathGlobal hypoperfusionNormal subjectsDiagnosis of HIEHypoxic-ischemic brain injuryMatter regionsHypoxic-ischemic injuryIschemic brain injurySex-matched controlsLow b-value DWIApparent diffusion coefficient (ADC) valuesGray matter regionsWhite matter regionsWhite matter valuesIschemic encephalopathyDelayed DiagnosisArrest patientsCardiopulmonary arrestCardiorespiratory arrestBrain injuryInclusion criteriaBD subjectsOrgan donorsGray matter
2017
Carotid intraplaque hemorrhage on vessel wall MRI does not correlate with TCD emboli monitoring in patients with recently symptomatic carotid atherosclerosis
de Havenon A, Tirschwell D, Majersik JJ, McNally S, Stoddard G, Moore A, Mossa-Basha M. Carotid intraplaque hemorrhage on vessel wall MRI does not correlate with TCD emboli monitoring in patients with recently symptomatic carotid atherosclerosis. The Neuroradiology Journal 2017, 30: 486-489. PMID: 28631982, PMCID: PMC5602332, DOI: 10.1177/1971400917707351.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeSymptomatic carotid atherosclerosisCarotid atherosclerosisMicroembolic signalsIntraplaque hemorrhageCarotid intraplaque hemorrhageTranscranial DopplerVessel wall MRIIschemic strokeEmboli monitoringPresence of IPHRecent acute ischemic strokeTransient ischemic attackWarrants prospective studiesAcute stroke patientsRetrospective chart reviewRisk of strokeIschemic attackChart reviewProspective studyStroke patientsResults TwentyInclusion criteriaLarge cohortVolumetric MRI
2016
Treatment of Carotid Intramural Thrombus With TPA
Bennett A, Wold J, de Havenon A. Treatment of Carotid Intramural Thrombus With TPA. JAMA Neurology 2016, 73: 1496. PMID: 27802501, DOI: 10.1001/jamaneurol.2016.3223.Peer-Reviewed Original ResearchComputed Tomography AngiographyDiffusion Magnetic Resonance ImagingFibrinolytic AgentsHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedThrombosisTissue Plasminogen ActivatorVessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke
de Havenon A, Park M, McNally S. Vessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke. Neurology 2016, 87: 741-742. PMID: 27527539, PMCID: PMC4999170, DOI: 10.1212/wnl.0000000000002990.Peer-Reviewed Original Research