2020
The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patients
2019
Blood pressure, glycemic control, and white matter hyperintensity progression in type 2 diabetics
de Havenon A, Majersik JJ, Tirschwell DL, McNally JS, Stoddard G, Rost NS. Blood pressure, glycemic control, and white matter hyperintensity progression in type 2 diabetics. Neurology 2019, 92: e1168-e1175. PMID: 30737332, PMCID: PMC6511110, DOI: 10.1212/wnl.0000000000007093.Peer-Reviewed Original ResearchConceptsType 2 diabeticsBlood pressureWhite matter hyperintensitiesRandomization armGlycemic controlWMH progressionHigher systolic blood pressureWhite matter hyperintensity progressionIntensive blood pressureBlood pressure controlSystolic blood pressureHigh blood pressureType 2 diabetesACCORD-MINDComorbid diabetesMacrovascular complicationsCardiovascular riskHemoglobin A1cPrimary outcomeControl armMatter hyperintensitiesAggressive approachWMH volumeControl interventionsPressure control