2023
Prestroke and Poststroke Sulfonylurea Exposure and Functional Outcomes: A Post Hoc Analysis of the SHINE Trial
Shu L, Zhang W, Yaghi S, Grilli A, de Havenon A, Barrett K, Johnston K, Goldstein E. Prestroke and Poststroke Sulfonylurea Exposure and Functional Outcomes: A Post Hoc Analysis of the SHINE Trial. Stroke 2023, 54: e415-e416. PMID: 37449423, PMCID: PMC10527636, DOI: 10.1161/strokeaha.123.043496.Peer-Reviewed Original Research
2021
Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial
de Havenon A, Anadani M, Prabhakaran S, Wong K, Yaghi S, Rost N. Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial. Journal Of The American Heart Association 2021, 10: e022206. PMID: 34533059, PMCID: PMC8649507, DOI: 10.1161/jaha.121.022206.Peer-Reviewed Original ResearchConceptsBlood pressure controlBlood pressure variabilityMild cognitive impairmentCognitive impairmentProbable dementiaMIND trialBlood pressurePressure variabilityExcellent blood pressure controlPressure controlSuboptimal blood pressure controlSystolic blood pressure variabilityCox proportional hazards modelRisk of dementiaBlood pressure measurementsProportional hazards modelRate of dementiaPost Hoc AnalysisLowest tertileHighest tertilePrimary outcomeCardiovascular diseaseHoc AnalysisCox modelHazards modelPenumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial
Yaghi S, Raz E, Dehkharghani S, Riina H, McTaggart R, Jayaraman M, Prabhakaran S, Liebeskind DS, Khatri P, Mac Grory B, Al-Mufti F, Lansberg M, Albers G, de Havenon A. Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial. Stroke 2021, 52: 2690-2693. PMID: 34157865, DOI: 10.1161/strokeaha.120.033806.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsLarge vessel occlusionPenumbral tissueVessel occlusionMismatch volumeAcute large vessel occlusionAnterior circulation occlusionEndovascular thrombectomy patientsAcute ischemic strokePost Hoc AnalysisReperfusion statusThrombectomy patientsTICI 0Cerebral infarctionEndovascular thrombectomyIschemic strokeUntreated patientsPrimary outcomeSalvageable tissueTreatment modalitiesHoc AnalysisPerfusion timePatientsNatural historyOcclusion