2017
Multiple evolutionary origins of Trypanosoma evansi in Kenya
Kamidi CM, Saarman NP, Dion K, Mireji PO, Ouma C, Murilla G, Aksoy S, Schnaufer A, Caccone A. Multiple evolutionary origins of Trypanosoma evansi in Kenya. PLOS Neglected Tropical Diseases 2017, 11: e0005895. PMID: 28880965, PMCID: PMC5605091, DOI: 10.1371/journal.pntd.0005895.Peer-Reviewed Original ResearchConceptsT. brucei strainsDifferent genetic backgroundsEvolutionary originGenetic diversityBrucei strainsMultiple evolutionary originsGenetic backgroundTsetse fly vectorT. evansiLethal human diseaseIndependent originsPolymorphic microsatellitesT. bruceiEvansi isolatesGenetic unitsHuman diseasesObligate linkBruceiEvansi strainsT. brucei bruceiTsetse fliesFly vectorsFliesDiversityBrucei brucei
2016
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
Graf F, Ludin P, Arquint C, Schmidt R, Schaub N, Kunz Renggli C, Munday J, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning H, Mäser P. Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular And Molecular Life Sciences 2016, 73: 3387-3400. PMID: 26973180, PMCID: PMC4967103, DOI: 10.1007/s00018-016-2173-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAquaporinsComparative Genomic HybridizationDNA, ProtozoanDrug ResistanceGenome, ProtozoanHeterozygoteHumansMaleMelarsoprolNucleoside Transport ProteinsParasitic Sensitivity TestsPentamidinePhenotypePolymorphism, Single NucleotideProtozoan ProteinsRNA-Binding ProteinsSequence AlignmentTrypanocidal AgentsTrypanosoma brucei rhodesienseTrypanosomiasis, African
2015
Genetic Diversity and Population Structure of Trypanosoma brucei in Uganda: Implications for the Epidemiology of Sleeping Sickness and Nagana
Echodu R, Sistrom M, Bateta R, Murilla G, Okedi L, Aksoy S, Enyioha C, Enyaru J, Opiyo E, Gibson W, Caccone A. Genetic Diversity and Population Structure of Trypanosoma brucei in Uganda: Implications for the Epidemiology of Sleeping Sickness and Nagana. PLOS Neglected Tropical Diseases 2015, 9: e0003353. PMID: 25695634, PMCID: PMC4335064, DOI: 10.1371/journal.pntd.0003353.Peer-Reviewed Original Research
2012
Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance
Symula RE, Beadell JS, Sistrom M, Agbebakun K, Balmer O, Gibson W, Aksoy S, Caccone A. Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance. PLOS Neglected Tropical Diseases 2012, 6: e1728. PMID: 22802982, PMCID: PMC3393672, DOI: 10.1371/journal.pntd.0001728.Peer-Reviewed Original ResearchConceptsTrypanosome lytic factorHuman serum resistanceGroup 2Group 1Serum resistanceHaptoglobin-hemoglobin receptorHuman serumHuman African trypanosomiasisInnate immunityTrypanosoma brucei rhodesienseUnique amino acid substitutionsAltered activityLytic factorCausative agentLytic activityHemoglobin receptorTLF-1African trypanosomiasisBrucei rhodesienseSerumReceptorsAmino acid substitutionsFurther evidenceHpHbRTBR
2011
Phylogeography and Taxonomy of Trypanosoma brucei
Balmer O, Beadell J, Gibson W, Caccone A. Phylogeography and Taxonomy of Trypanosoma brucei. PLOS Neglected Tropical Diseases 2011, 5: e961. PMID: 21347445, PMCID: PMC3035665, DOI: 10.1371/journal.pntd.0000961.Peer-Reviewed Original Research
2008
Multiple-strain infections of Trypanosoma brucei across Africa
Balmer O, Caccone A. Multiple-strain infections of Trypanosoma brucei across Africa. Acta Tropica 2008, 107: 275-279. PMID: 18671933, PMCID: PMC2582348, DOI: 10.1016/j.actatropica.2008.06.006.Peer-Reviewed Original Research