2017
Genomic insights into the ancient spread of Lyme disease across North America
Walter KS, Carpi G, Caccone A, Diuk-Wasser MA. Genomic insights into the ancient spread of Lyme disease across North America. Nature Ecology & Evolution 2017, 1: 1569-1576. PMID: 29185509, PMCID: PMC6431794, DOI: 10.1038/s41559-017-0282-8.Peer-Reviewed Original ResearchConceptsHistory of spreadEvolutionary historyNorth AmericaLyme disease epidemicLast Glacial MaximumAncient spreadLyme disease bacteriaComplex evolutionary historyPast centuryGlacial MaximumHistoryGenomic insightsEvolutionary changeAmericaUndocumented levelB. burgdorferi s.Large collectionSensu strictoBurgdorferi s.Vector-borne diseasesSouthern CanadaLand use changeBorrelia burgdorferi sensu strictoCenturyDisease bacteria
2016
Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States
Carpi G, Walter KS, Mamoun CB, Krause PJ, Kitchen A, Lepore TJ, Dwivedi A, Cornillot E, Caccone A, Diuk-Wasser MA. Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States. BMC Genomics 2016, 17: 888. PMID: 27821055, PMCID: PMC5100190, DOI: 10.1186/s12864-016-3225-x.Peer-Reviewed Original ResearchConceptsStrong population structurePopulation structureGenome-wide diversityDifferentiated genetic clustersRecent population expansionB. microti samplesTick-borne apicomplexan parasiteB. microtiNortheastern USAGene flowEvolutionary originApicomplexan parasitesApicoplast genomeGenetic clustersGenomic variationPopulation expansionGeographic rangeRange expansionGenomic signaturesCurrent diversityHuman-derived samplesInfectious phenotypeTick vectorCapture strategyDiversity