2018
Uncovering Genomic Regions Associated with Trypanosoma Infections in Wild Populations of the Tsetse Fly Glossina fuscipes
Gloria-Soria A, Dunn WA, Yu X, Vigneron A, Lee KY, Li M, Weiss BL, Zhao H, Aksoy S, Caccone A. Uncovering Genomic Regions Associated with Trypanosoma Infections in Wild Populations of the Tsetse Fly Glossina fuscipes. G3: Genes, Genomes, Genetics 2018, 8: 887-897. PMID: 29343494, PMCID: PMC5844309, DOI: 10.1534/g3.117.300493.Peer-Reviewed Original ResearchConceptsGenomic resourcesRelated speciesCandidate genesNonmodel organismsTranscript librariesFunctional genomicsTranscriptome assemblyFunctional annotationWild populationsPhysiological traitsGenomic regionsDNA regulationMost speciesRNAseq experimentsGenetic basisLaboratory coloniesGenesFunctional studiesPolymorphic sitesSpeciesTrypanosome infection statusGenomeNew assemblyTrypanosoma infectionFlies
2014
Comparative Genomics Reveals Multiple Genetic Backgrounds of Human Pathogenicity in the Trypanosoma brucei Complex
Sistrom M, Evans B, Bjornson R, Gibson W, Balmer O, Mäser P, Aksoy S, Caccone A. Comparative Genomics Reveals Multiple Genetic Backgrounds of Human Pathogenicity in the Trypanosoma brucei Complex. Genome Biology And Evolution 2014, 6: 2811-2819. PMID: 25287146, PMCID: PMC4224348, DOI: 10.1093/gbe/evu222.Peer-Reviewed Original ResearchConceptsT. brucei complexGenomic variationLife historyVariable life historiesAverage linkage disequilibriumTrypanosoma brucei complexGenome-wide studiesMeiotic reciprocal recombinationWhole genome sequencesMultiple genetic backgroundsHuman pathogenicityNumber of subspeciesHuman-infective parasiteNuclear genomeComparative genomicsChromosome sizeEukaryotic parasitesGenomic regionsHuman African trypanosomiasisRegulatory genesTaxonomic designationsDiverse hostsSingle nucleotide polymorphismsGenetic variationReciprocal recombination
2007
Multiple Origins of Knockdown Resistance Mutations in the Afrotropical Mosquito Vector Anopheles gambiae
Pinto J, Lynd A, Vicente J, Santolamazza F, Randle N, Gentile G, Moreno M, Simard F, Charlwood J, do Rosário V, Caccone A, della Torre A, Donnelly M. Multiple Origins of Knockdown Resistance Mutations in the Afrotropical Mosquito Vector Anopheles gambiae. PLOS ONE 2007, 2: e1243. PMID: 18043750, PMCID: PMC2080755, DOI: 10.1371/journal.pone.0001243.Peer-Reviewed Original ResearchConceptsResistance allelesMutation eventsMosquito vector Anopheles gambiaeVoltage-gated sodium channel geneNatural insect populationsEvolution of resistanceInsecticide resistance mutationsIndependent mutation eventsGambiae S formSodium channel geneMalaria vector AnophelesKnockdown resistance alleleKnockdown resistance (kdr) mutationsGene flowMolecular evolutionNeutrality testsSelective sweepsMalaria vector control programmesAdaptive traitsMultiple mutation eventsInsect populationsGenomic regionsHaplotype compositionKdr locusLocal selection
1997
Genetic Differentiation Within the European Sea Bass (D. labrax) as Revealed by RAPD-PCR Assays
Caccone A, Allegrucci G, Fortunato C, Sbordoni V. Genetic Differentiation Within the European Sea Bass (D. labrax) as Revealed by RAPD-PCR Assays. Journal Of Heredity 1997, 88: 316-324. DOI: 10.1093/oxfordjournals.jhered.a023109.Peer-Reviewed Original ResearchGenetic differentiationRAPD-PCR assayEuropean sea bassRAPD markersPopulation genetic differentiationSea bassFreshwater acclimationAllozyme dataMicrosatellite surveyRAPD variationCongeneric speciesGenomic regionsMediterranean localitiesFish speciesHatchery samplesRAPD differentiationAtlantic samplesRAPD bandsWild samplesDNA polymorphismsSame speciesAcclimation experimentsDifferential survivalMediterranean populationsEcological components