2018
Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya.
Okeyo WA, Saarman NP, Bateta R, Dion K, Mengual M, Mireji PO, Ouma C, Okoth S, Murilla G, Aksoy S, Caccone A. Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya. American Journal Of Tropical Medicine And Hygiene 2018, 99: 945-953. PMID: 30105964, PMCID: PMC6159567, DOI: 10.4269/ajtmh.18-0154.Peer-Reviewed Original ResearchConceptsGenetic differentiationPopulation dynamicsDispersal patternsTsetse fliesLow genetic diversityGreater genetic differentiationEvidence of admixtureWestern clusterEastern clusterRecent anthropogenic influencesAnimal African trypanosomiasisGenetic connectivityWestern relativesGenetic diversityMicrosatellite lociPopulation structureGenotypic dataWidespread signalDisease vectorsMajor vectorVector control effortsGreat Rift ValleyDemographic parametersFliesVector control programs
2017
Theory, practice, and conservation in the age of genomics: The Galápagos giant tortoise as a case study
Gaughran S, Quinzin M, Miller J, Garrick R, Edwards D, Russello M, Poulakakis N, Ciofi C, Beheregaray L, Caccone A. Theory, practice, and conservation in the age of genomics: The Galápagos giant tortoise as a case study. Evolutionary Applications 2017, 11: 1084-1093. PMID: 30026799, PMCID: PMC6050186, DOI: 10.1111/eva.12551.Peer-Reviewed Original ResearchGalápagos giant tortoisesSingle nucleotide polymorphismsGenetic differentiationPopulation structureGiant tortoisesRecent single nucleotide polymorphismGenomewide single nucleotide polymorphismsGenomic single nucleotide polymorphismsGiant tortoise speciesHigh-throughput DNA sequencingStructured natural populationsHundreds of SNPsThousands of SNPsPopulation genetics theoryTraditional genetic markersAge of genomicsMitochondrial DNA analysisNonmodel organismsNonmodel speciesEvolutionary historyNatural populationsGenetic theoryTortoise speciesUnnatural groupingGenomic dataTemporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya
Okeyo WA, Saarman NP, Mengual M, Dion K, Bateta R, Mireji PO, Okoth S, Ouma JO, Ouma C, Ochieng J, Murilla G, Aksoy S, Caccone A. Temporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya. Parasites & Vectors 2017, 10: 471. PMID: 29017572, PMCID: PMC5635580, DOI: 10.1186/s13071-017-2415-y.Peer-Reviewed Original ResearchConceptsTemporal genetic differentiationGenetic diversityGenetic differentiationGenetic bottleneckGenetic variationNational ParkTemporal genetic variationExtensive control measuresAnimal African trypanosomiasisAllelic richnessPairwise FSTGenetic driftNe estimatesHabitat alterationPopulation geneticsTemporal differentiationMicrosatellite markersRuma National ParkClosest sampling sitesG. pallidipesMajor vectorTsetse fliesVector populationsDifferentiationDiversity
2015
Mitochondrial DNA sequence divergence and diversity of Glossina fuscipes fuscipes in the Lake Victoria basin of Uganda: implications for control
Kato AB, Hyseni C, Okedi LM, Ouma JO, Aksoy S, Caccone A, Masembe C. Mitochondrial DNA sequence divergence and diversity of Glossina fuscipes fuscipes in the Lake Victoria basin of Uganda: implications for control. Parasites & Vectors 2015, 8: 385. PMID: 26197892, PMCID: PMC4511262, DOI: 10.1186/s13071-015-0984-1.Peer-Reviewed Original ResearchConceptsMicrosatellite loci dataDemographic historyGenetic differentiationMicrosatellite dataLoci dataMitochondrial DNA (mtDNA) cytochrome oxidase II geneGenetic variationMitochondrial DNA sequence divergenceCytochrome oxidase II geneWeak genetic differentiationDNA sequence divergenceLake Victoria basinGenetic structuringGene flowDemographic testsGenetic divergenceMtDNA dataSequence divergenceGenetic diversityGeographic distanceVictoria basinGenetic analysisSampling sitesMutation ratePopulation clustersGenetics of a head-start program to guide conservation of an endangered Galápagos tortoise (Chelonoidis ephippium)
Jensen E, Tapia W, Caccone A, Russello M. Genetics of a head-start program to guide conservation of an endangered Galápagos tortoise (Chelonoidis ephippium). Conservation Genetics 2015, 16: 823-832. DOI: 10.1007/s10592-015-0703-7.Peer-Reviewed Original ResearchGalápagos tortoisesEx situ conservation strategiesEx situ conservation programsWild populationsMicrosatellite genotypic dataSitu conservation strategiesSitu conservation programsGenetic variationGiant Galápagos tortoisesSignificant genetic differentiationPopulation genetic variationEx situ approachesConservation strategiesConservation interventionsConservation programsWildlife speciesCaptive foundersPinzón IslandCaptive populationsGenetic differentiationBreadth of diversityIntensive managementGiant tortoisesPrivate allelesManagement decisions
2014
Worldwide phylogeography of the invasive ctenophore Mnemiopsis leidyi (Ctenophora) based on nuclear and mitochondrial DNA data
Bayha K, Chang M, Mariani C, Richardson J, Edwards D, DeBoer T, Moseley C, Aksoy E, Decker M, Gaffney P, Harbison G, McDonald J, Caccone A. Worldwide phylogeography of the invasive ctenophore Mnemiopsis leidyi (Ctenophora) based on nuclear and mitochondrial DNA data. Biological Invasions 2014, 17: 827-850. DOI: 10.1007/s10530-014-0770-6.Peer-Reviewed Original ResearchMicrosatellite data setsCtenophore Mnemiopsis leidyiM. leidyiGenetic differentiationCytb dataInvasion historyNative rangeAtlantic coastMicrosatellite dataMnemiopsis leidyiBaltic SeaInvasive ctenophore Mnemiopsis leidyiNuclear microsatellite lociConsiderable gene flowConsiderable genetic differentiationUS Atlantic coastMitochondrial DNA dataCape HatterasSouthern invasionsGulf of MexicoFishery collapseNorthern invasionPelagic ecologyBiogeographic boundariesPhylogeographic patternsCryptic structure and niche divergence within threatened Galápagos giant tortoises from southern Isabela Island
Edwards D, Garrick R, Tapia W, Caccone A. Cryptic structure and niche divergence within threatened Galápagos giant tortoises from southern Isabela Island. Conservation Genetics 2014, 15: 1357-1369. DOI: 10.1007/s10592-014-0622-z.Peer-Reviewed Original ResearchSouthern Isabela IslandGalápagos giant tortoisesGenetic clustersIsabela IslandGiant tortoisesMorphological diversityRecent gene flowBiodiversity lossConservation managementEcological divergenceSignificant unitsNiche divergenceFeral animalsEcological factorsGenetic differentiationEcological nichesGene flowCryptic structureMicrosatellite lociManagement successSpatial distributionCurrent taxonomyTortoisesManagement programDiversity
2013
Habitat fragmentation and the genetic structure of the Amazonian palm Mauritia flexuosa L.f. (Arecaceae) on the island of Trinidad
Federman S, Hyseni C, Clement W, Oatham M, Caccone A. Habitat fragmentation and the genetic structure of the Amazonian palm Mauritia flexuosa L.f. (Arecaceae) on the island of Trinidad. Conservation Genetics 2013, 15: 355-362. DOI: 10.1007/s10592-013-0543-2.Peer-Reviewed Original ResearchIsland of TrinidadGenetic structureAnimal-mediated seed dispersalSmall-scale spatial genetic structureLand use changeNearest-neighbor matingSpatial genetic structureTemporal genetic patternsMauritia flexuosa L.fHabitat fragmentationSuccessful conservationSeed dispersalAnthropogenic changesScientific ReserveMauritia flexuosaGenetic differentiationManagement planGene flowGenetic patternsStudy sitesGenetic diversitySmall collection areaGenetic exchangeWild populationsPopulation's abilityGenetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis
Echodu R, Sistrom M, Hyseni C, Enyaru J, Okedi L, Aksoy S, Caccone A. Genetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis. BioMed Research International 2013, 2013: 614721. PMID: 24199195, PMCID: PMC3807537, DOI: 10.1155/2013/614721.Peer-Reviewed Original ResearchConceptsSex-biased dispersalMicrosatellite DNA dataLack of admixtureAgents of humanVicariant barrierGenetic differentiationSouthern populationsDNA dataTrypanosoma bruceiCompetitive exclusionMain vector speciesSole vectorsContact zonePopulation clustersVector speciesEnvironmental conditionsTsetse fliesDistinct groupsAnimal trypanosomiasisHuman African trypanosomiasisGlossinaAfrican trypanosomiasisIntrogressionSympatryDispersalWolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics
Symula RE, Alam U, Brelsfoard C, Wu Y, Echodu R, Okedi LM, Aksoy S, Caccone A. Wolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics. BMC Ecology And Evolution 2013, 13: 31. PMID: 23384159, PMCID: PMC3574847, DOI: 10.1186/1471-2148-13-31.Peer-Reviewed Original ResearchConceptsMtDNA haplotypesDifferent WolbachiaGenetic diversityHost haplotypesSequence diversityMultiple WolbachiaArthropod host reproductionPopulation genetic differentiationComplex evolutionary dynamicsMitochondrial DNA haplotypesAssociation of WolbachiaLow reproductive outputHost population geneticsHost genetic diversityTsetse fliesMulti-locus sequence typingMost WolbachiaHost genetic compositionGenetic differentiationWolbachia evolutionWolbachia associationsHost reproductionDNA haplotypesMtDNA groupsΑ-proteobacteria
2012
Genetic isolation within the malaria mosquito Anopheles melas
Deitz K, Athrey G, Reddy M, Overgaard H, Matias A, Jawara M, della Torre A, Petrarca V, Pinto J, Kiszewski A, Kengne P, Costantini C, Caccone A, Slotman M. Genetic isolation within the malaria mosquito Anopheles melas. Molecular Ecology 2012, 21: 4498-4513. PMID: 22882458, PMCID: PMC4067978, DOI: 10.1111/j.1365-294x.2012.05724.x.Peer-Reviewed Original ResearchConceptsMicrosatellite dataIsland populationsGambiae complexMaximum likelihood phylogenetic analysisBp of mtDNALevel of divergenceLast glaciation periodA. gambiae complexMalaria vectorsSalt marsh grassAnopheles gambiae complexAnopheles melasMajor malaria vectorApproximate Bayesian analysisMtDNA divergenceGenetic differentiationGenetic divergenceGenetic isolationMainland populationsPhylogenetic analysisPopulation structureMicrosatellite markersLarval habitatsA. gambiaeGlaciation period
2010
Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago)
Lanterbecq D, Glaberman S, Vitousek M, Steinfartz S, Benavides E, Wikelski M, Caccone A. Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago). Journal Of Heredity 2010, 101: 663-675. PMID: 20538757, DOI: 10.1093/jhered/esq067.Peer-Reviewed Original ResearchConceptsMarine iguanasGenetic diversitySex-biased dispersalMitochondrial control regionMitochondrial DNA markersGalápagos marine iguanasSanta FéDifferent breeding sitesSouthern sitesGenetic differentiationEvolutionary signalGenetic structureMicrosatellite lociDNA markersControl regionGenetic variationGenetic patternsBreeding sitesLittle differentiationBase pairsNeighboring islandsIguanasDiversitySampling sitesDifferentiation
2009
Progressive colonization and restricted gene flow shape island-dependent population structure in Galápagos marine iguanas (Amblyrhynchus cristatus)
Steinfartz S, Glaberman S, Lanterbecq D, Russello M, Rosa S, Hanley T, Marquez C, Snell H, Snell H, Gentile G, Dell'Olmo G, Powell A, Caccone A. Progressive colonization and restricted gene flow shape island-dependent population structure in Galápagos marine iguanas (Amblyrhynchus cristatus). BMC Ecology And Evolution 2009, 9: 297. PMID: 20028547, PMCID: PMC2807874, DOI: 10.1186/1471-2148-9-297.Peer-Reviewed Original ResearchConceptsComplete mitochondrial control regionMarine iguanasGene flowPopulation structureMarine iguana populationsHistorical gene flowNuclear gene flowMicrosatellite genetic diversityStrong genetic differentiationMale-biased dispersalMitochondrial control regionRecent population expansionBayesian cluster analysisGalápagos marine iguanasHaplotype distribution patternsDistinct genetic clustersPast genetic studiesGenetic differentiationWestern islandsFST estimatesIguana populationsFounder eventsFST analysisDifferent inheritance patternsGenetic clustersMorphometrics Parallel Genetics in a Newly Discovered and Endangered Taxon of Galápagos Tortoise
Chiari Y, Hyseni C, Fritts T, Glaberman S, Marquez C, Gibbs J, Claude J, Caccone A. Morphometrics Parallel Genetics in a Newly Discovered and Endangered Taxon of Galápagos Tortoise. PLOS ONE 2009, 4: e6272. PMID: 19609441, PMCID: PMC2707613, DOI: 10.1371/journal.pone.0006272.Peer-Reviewed Original ResearchConceptsGalápagos tortoisesGenetic variationGenetic distinctionTortoise populationsNon-neutral lociStrong genetic differentiationComplex heritable traitsDiagnostic morphological charactersShell morphologyShell shape variationGenetic differentiationMitochondrial dataMonophyletic lineageMorphological charactersGiant tortoisesHeritable traitGenetic dataMost islandsSanta CruzMolecular studiesShell shapeTurtle shellTortoisesLineagesParallel Genetic
2008
High Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau
Oliveira E, Salgueiro P, Palsson K, Vicente J, Arez A, Jaenson T, Caccone A, Pinto J. High Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau. Journal Of Medical Entomology 2008, 45: 1057-1063. DOI: 10.1093/jmedent/45.6.1057.Peer-Reviewed Original ResearchConceptsGenetic differentiationIncipient speciationSignificant genetic differentiationSpecies distribution rangeLow recombination regionsDegree of isolationMalaria vector AnophelesSamples of AnChromosome 3Distribution rangeLocus mapsAnopheles gambiaeHigh differentiationS formChromosome XGiles sensu strictoForm compositionSensu strictoVector AnophelesGambiaeMolecular formsS hybridsMicrosatellitesDifferentiationRecombination regionHigh Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau
Oliveira E, Salgueiro P, Palsson K, Vicente J, Arez A, Jaenson T, Caccone A, Pinto J. High Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau. Journal Of Medical Entomology 2008, 51 DOI: 10.1603/0022-2585(2008)45[1057:hlohbm]2.0.co;2.Peer-Reviewed Original ResearchGenetic differentiationIncipient speciationSignificant genetic differentiationSpecies distribution rangeLow recombination regionsDegree of isolationMalaria vector AnophelesSamples of AnChromosome 3Distribution rangeLocus mapsAnopheles gambiaeHigh differentiationS formChromosome XGiles sensu strictoForm compositionSensu strictoVector AnophelesGambiaeMolecular formsS hybridsMicrosatellitesDifferentiationRecombination regionHigh levels of hybridization between molecular forms of Anopheles gambiae from Guinea Bissau.
Oliveira E, Salgueiro P, Palsson K, Vicente J, Arez A, Jaenson T, Caccone A, Pinto J. High levels of hybridization between molecular forms of Anopheles gambiae from Guinea Bissau. Journal Of Medical Entomology 2008, 45: 1057-63. PMID: 19058629, DOI: 10.1603/0022-2585(2008)45[1057:hlohbm]2.0.co;2.Peer-Reviewed Original ResearchConceptsGenetic differentiationIncipient speciationSignificant genetic differentiationSpecies distribution rangeLow recombination regionsDegree of isolationMalaria vector AnophelesSamples of AnChromosome 3Distribution rangeLocus mapsAnopheles gambiaeHigh differentiationS formChromosome XGiles sensu strictoForm compositionSensu strictoVector AnophelesGambiaeMolecular formsS hybridsMicrosatellitesDifferentiationRecombination regionHigh Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau
Oliveira E, Salgueiro P, Palsson K, Vicente J, Arez A, Jaenson T, Caccone A, Pinto J. High Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau. Journal Of Medical Entomology 2008, 45: 1057-1063. DOI: 10.1603/0022-2585%282008%2945%5b1057%3ahlohbm%5d2.0.co%3b2.Peer-Reviewed Original ResearchGenetic differentiationIncipient speciationSignificant genetic differentiationSpecies distribution rangeLow recombination regionsDegree of isolationMalaria vector AnophelesSamples of AnChromosome 3Distribution rangeLocus mapsAnopheles gambiaeHigh differentiationS formChromosome XGiles sensu strictoForm compositionSensu strictoVector AnophelesGambiaeMolecular formsS hybridsMicrosatellitesDifferentiationRecombination regionCorrection: High Levels of Genetic Differentiation between Ugandan Glossina fuscipes fuscipes Populations Separated by Lake Kyoga
Abila P, Slotman M, Parmakelis A, Dion K, Robinson A, Muwanika V, Enyaru J, Okedi L, Aksoy S, Caccone A. Correction: High Levels of Genetic Differentiation between Ugandan Glossina fuscipes fuscipes Populations Separated by Lake Kyoga. PLOS Neglected Tropical Diseases 2008, 2: 10.1371/annotation/bc182916-f740-4366-b50e-80410649f197. PMCID: PMC2645277, DOI: 10.1371/annotation/bc182916-f740-4366-b50e-80410649f197.Peer-Reviewed Original ResearchHigh Levels of Genetic Differentiation between Ugandan Glossina fuscipes fuscipes Populations Separated by Lake Kyoga
Abila PP, Slotman MA, Parmakelis A, Dion KB, Robinson AS, Muwanika VB, Enyaru JC, Lokedi L, Aksoy S, Caccone A. High Levels of Genetic Differentiation between Ugandan Glossina fuscipes fuscipes Populations Separated by Lake Kyoga. PLOS Neglected Tropical Diseases 2008, 2: e242. PMID: 18509474, PMCID: PMC2386243, DOI: 10.1371/journal.pntd.0000242.Peer-Reviewed Original Research