2018
Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA
Goldberg SB, Narayan A, Kole AJ, Decker RH, Teysir J, Carriero NJ, Lee A, Nemati R, Nath SK, Mane SM, Deng Y, Sukumar N, Zelterman D, Boffa DJ, Politi K, Gettinger S, Wilson LD, Herbst RS, Patel AA. Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. Clinical Cancer Research 2018, 24: 1872-1880. PMID: 29330207, PMCID: PMC5899677, DOI: 10.1158/1078-0432.ccr-17-1341.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerImmune checkpoint inhibitorsCtDNA responseCheckpoint inhibitorsCtDNA levelsMetastatic non-small cell lung cancerImmune checkpoint inhibitor therapySuperior progression-free survivalRadiographic tumor sizeCheckpoint inhibitor therapyProgression-free survivalSuperior overall survivalTumor DNA levelsCell lung cancerAllele fractionClin Cancer ResMultigene next-generation sequencingMutant allele fractionTumor cell deathInhibitor therapyOverall survivalRadiographic responseImmunotherapy efficacyImmunotherapy responseMedian time
2009
Implications of Respiratory Motion as Measured by Four-Dimensional Computed Tomography for Radiation Treatment Planning of Esophageal Cancer
Patel AA, Wolfgang JA, Niemierko A, Hong TS, Yock T, Choi NC. Implications of Respiratory Motion as Measured by Four-Dimensional Computed Tomography for Radiation Treatment Planning of Esophageal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2009, 74: 290-296. PMID: 19362248, DOI: 10.1016/j.ijrobp.2008.12.060.Peer-Reviewed Original ResearchConceptsLymph nodesFour-dimensional computed tomographyPrimary tumorEsophageal cancerCT scanComputed tomographyRespiratory tumor motionDistal esophageal tumorsDistal thoracic esophagusEsophageal primary tumorsPrimary esophageal cancerMassachusetts General HospitalTumor motionRespiratory motionDistal tumorsCurative treatmentThoracic esophagusEsophageal tumorsGeneral HospitalLeft-right directionsAnatomic locationRadiation treatment planningLR dimensionAP motionTumors
2006
Estimation of the delivered patient dose in lung IMRT treatment based on deformable registration of 4D-CT data and Monte Carlo simulations
Flampouri S, Jiang SB, Sharp GC, Wolfgang J, Patel AA, Choi NC. Estimation of the delivered patient dose in lung IMRT treatment based on deformable registration of 4D-CT data and Monte Carlo simulations. Physics In Medicine And Biology 2006, 51: 2763-2779. PMID: 16723765, DOI: 10.1088/0031-9155/51/11/006.Peer-Reviewed Original ResearchConceptsHelical CTWhole breathing cycleFree-breathing CTBreathing phasesClinical outcomesRetrospective studyCT scanPrescribed dosePTV expansionCTV volumePatientsDoseEUD valuesIMRT plansGTVComposite dose distributionCTHealthy tissuePatient doseCT setsTumor motionBreathing cycleTreatment planning systemDosesIMRT treatment