Paul Heerdt, PhD, MD
Cards
Appointments
Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
About
Titles
Professor of Anesthesiology
Director of Applied Hemodynamics, AnesthesiologyBiography
Paul M. Heerdt is a Professor of Anesthesiology at Yale University School of Medicine. Dr. Heerdt earned his MD from the University of Tennessee in 1982 followed by a PhD in cardiovascular pharmacology in 1985. He completed his residency in anesthesiology at Massachusetts General Hospital in Boston and then a fellowship in cardiothoracic anesthesia at Washington University in St. Louis, MO.
Following clinical training, Dr. Heerdt remained on the faculty at Washington University for several years before moving to Cornell University in 1992. At Cornell, he was a faculty member in the departments of Anesthesiology and Pharmacology and also maintained an appointment at Memorial Sloan Kettering Center. In 2016 Dr. Heerdt moved to Yale where he has been conducting clinical and basic science research with a particular emphasis on developing collaborative opportunities for residents, fellows, and junior faculty. He serves on several committees within the Yale School of Medicine and lectures in the medical student pharmacology curriculum. Outside of Yale, Dr. Heerdt is active in the Society of Cardiovascular Anesthesiologists and a member of the editorial board for the Journal of Pharmacology and Experimental Therapeutics.
Appointments
Education & Training
- Resident
- Massachusetts General Hospital (1988)
- Fellow
- Washington University (1988)
- PhD
- University of Tennessee, Pharmacology (1985)
- Intern
- Blodgett Memorial Medical Center (1985)
- MD
- University of Tennessee College of Medicine (1982)
- BS
- Memphis State University (1978)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1990
Research
Overview
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Phillip Joseph, MD
Hannah Oakland
Akhil Khosla, MD
Edward Manning, MD, PhD
George Tellides, MD, PhD
Cardiovascular Diseases
Publications
2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingRight Ventricular Pressure Waveform Analysis – Clinical Relevance and Future Directions
Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis – Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024 DOI: 10.1053/j.jvca.2024.06.022.Peer-Reviewed Original ResearchAltmetricConceptsRight ventricular pressureRight ventricular functionVentricular pressureVentricular functionMeasuring right ventricular pressureMeasurements of right ventricular pressurePeak right ventricular pressurePulmonary artery pressureEvaluate cardiac functionPulmonary arteryStroke volume measurementsRight atriumCardiac functionDiastolic fillingSurgical patientsArterial pressureClinical valueDemonstrating utilityVolume measurementsMeasurements of pressurePressure waveformAccurate surrogateContinuous measurement of pressurePhysiological factorsEchocardiographyTime domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs
Keast T, Glass A, McCall P, Heerdt P, Shelley B. Time domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs. British Journal Of Anaesthesia 2024, 132: 1009. DOI: 10.1016/j.bja.2024.01.027.Peer-Reviewed Original ResearchThree-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.Peer-Reviewed Original ResearchEssential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2024, 13: 27. PMID: 38594738, PMCID: PMC11003027, DOI: 10.1186/s13741-024-00378-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRight heart physiologyPerioperative Quality InitiativePerioperative periodRight heartRight ventricular (RV) dysfunctionHeart physiologyRight-sided heart functionRight heart anatomyRight heart diseasePrevent subsequent morbidityRV dysfunctionPerioperative morbidityChronic health issuesHeart functionHeart diseasePerioperative careHeart anatomyPerioperative cliniciansMorbidityPatientsHealth issuesDysfunctionQuality InitiativePulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchAltmetricConceptsPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressure
2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchAltmetricConceptsInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesRight Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptions
2022
Non-invasive hemodynamic trends before and after delivery in severe preterm preeclampsia patients
Ackerman C, Bhinder J, Lipkind H, Reddy U, Alian A, Heerdt P, Chou J. Non-invasive hemodynamic trends before and after delivery in severe preterm preeclampsia patients. American Journal Of Obstetrics And Gynecology 2022, 226: s558. DOI: 10.1016/j.ajog.2021.11.924.Peer-Reviewed Original Research
2019
Response to letter by Drs. Bottinger and van der Hoorn
Berlin DA, Manoach S, Heerdt PM. Response to letter by Drs. Bottinger and van der Hoorn. Intensive Care Medicine Experimental 2019, 7: 31. PMID: 31172313, PMCID: PMC6554383, DOI: 10.1186/s40635-019-0258-x.Peer-Reviewed Original Research