2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingRight Ventricular Pressure Waveform Analysis – Clinical Relevance and Future Directions
Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis – Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024 DOI: 10.1053/j.jvca.2024.06.022.Peer-Reviewed Original ResearchRight ventricular pressureRight ventricular functionVentricular pressureVentricular functionMeasuring right ventricular pressureMeasurements of right ventricular pressurePeak right ventricular pressurePulmonary artery pressureEvaluate cardiac functionPulmonary arteryStroke volume measurementsRight atriumCardiac functionDiastolic fillingSurgical patientsArterial pressureClinical valueDemonstrating utilityVolume measurementsMeasurements of pressurePressure waveformAccurate surrogateContinuous measurement of pressurePhysiological factorsEchocardiographyTime domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs
Keast T, Glass A, McCall P, Heerdt P, Shelley B. Time domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs. British Journal Of Anaesthesia 2024, 132: 1009. DOI: 10.1016/j.bja.2024.01.027.Peer-Reviewed Original ResearchThree-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.Peer-Reviewed Original ResearchEssential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2024, 13: 27. PMID: 38594738, PMCID: PMC11003027, DOI: 10.1186/s13741-024-00378-8.Peer-Reviewed Original ResearchRight heart physiologyPerioperative Quality InitiativePerioperative periodRight heartRight ventricular (RV) dysfunctionHeart physiologyRight-sided heart functionRight heart anatomyRight heart diseasePrevent subsequent morbidityRV dysfunctionPerioperative morbidityChronic health issuesHeart functionHeart diseasePerioperative careHeart anatomyPerioperative cliniciansMorbidityPatientsHealth issuesDysfunctionQuality InitiativePulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressure
2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesRight Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptions
2022
Non-invasive hemodynamic trends before and after delivery in severe preterm preeclampsia patients
Ackerman C, Bhinder J, Lipkind H, Reddy U, Alian A, Heerdt P, Chou J. Non-invasive hemodynamic trends before and after delivery in severe preterm preeclampsia patients. American Journal Of Obstetrics And Gynecology 2022, 226: s558. DOI: 10.1016/j.ajog.2021.11.924.Peer-Reviewed Original Research
2019
Response to letter by Drs. Bottinger and van der Hoorn
Berlin DA, Manoach S, Heerdt PM. Response to letter by Drs. Bottinger and van der Hoorn. Intensive Care Medicine Experimental 2019, 7: 31. PMID: 31172313, PMCID: PMC6554383, DOI: 10.1186/s40635-019-0258-x.Peer-Reviewed Original ResearchGlymphatic System Function in Relation to Anesthesia and Sleep States
Benveniste H, Heerdt PM, Fontes M, Rothman DL, Volkow ND. Glymphatic System Function in Relation to Anesthesia and Sleep States. Anesthesia & Analgesia 2019, 128: 747-758. PMID: 30883420, DOI: 10.1213/ane.0000000000004069.Peer-Reviewed Original ResearchConceptsEye movement sleepGlymphatic systemMovement sleepNon-rapid eye movement sleepRapid eye movement (REM) sleepTight blood-brain barrierCentral nervous system tissueCerebral oxygen consumptionCritical care settingBlood-brain barrierGlymphatic system functionCentral nervous systemNervous system tissueCerebrospinal fluid flowAnesthetic regimensBrain glymphatic systemBrain parenchymaCognitive dysfunctionCare settingsNervous systemClinical explorationWaste clearanceWakefulness persistLymphatic systemKey anatomical componentsAutomated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output
Berlin DA, Manoach S, Oromendia C, Heerdt PM. Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output. Intensive Care Medicine Experimental 2019, 7: 6. PMID: 30627962, PMCID: PMC6326914, DOI: 10.1186/s40635-018-0217-y.Peer-Reviewed Original ResearchConventional positive pressure ventilationExpiratory ventilation assistancePositive pressure ventilationSmall endotracheal tubeMedian cardiac outputVenous returnCardiac outputPressure ventilationEndotracheal tubeArterial pressureConventional ventilationVentilation assistanceLow central venous pressureCentral venous pressureSystemic arterial pressureEVA groupPEEP 0Venous pressureExpiratory pressureStroke volumeControl groupPorcine modelEffective ventilationVentilationHemorrhage
2018
Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine.
Savarese JJ, Sunaga H, McGilvra JD, Belmont MR, Murrell MT, Jeannotte E, Cooke FE, Wastila WB, Heerdt PM. Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine. Anesthesiology 2018, 129: 970-988. PMID: 30212413, DOI: 10.1097/aln.0000000000002408.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking agentsMean arterial pressureBlocking agentArterial pressureNeuromuscular blockadeHeart rateNew neuromuscular blocking agentRhesus monkeysNondepolarizing neuromuscular blocking agentDuration of actionStudy of bolusCirculatory effectsPreclinical pharmacologyControl infusionInstitutional Animal CareED95Large dosesSpontaneous recoveryGantacuriumDose ratioL-cysteineInfusionBolusUse CommitteeRecovery intervalBlood Pressure Targets in Perioperative Care
Meng L, Yu W, Wang T, Zhang L, Heerdt PM, Gelb AW. Blood Pressure Targets in Perioperative Care. Hypertension 2018, 72: 806-817. PMID: 30354725, DOI: 10.1161/hypertensionaha.118.11688.Peer-Reviewed Original ResearchPharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers
Kaullen JD, Owen JS, Brouwer KLR, Heerdt PM, Lien CA, Savarese JJ, Schmith VD. Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers. Anesthesiology 2018, 128: 1107-1116. PMID: 29494403, PMCID: PMC5953789, DOI: 10.1097/aln.0000000000002157.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking agentsBlocking agentRapid onsetPharmacodynamic modelDifferent dose cohortsMuscle twitch heightOffset of effectSingle ascending dosePharmacokinetic/Pharmacodynamic ModelArterial plasma concentrationsIntermediate durationPlasma drug concentration dataSigmoid Emax modelDose-response studyDrug concentration dataConcentration-time dataLow interindividual variabilityDose cohortsED95 dosesAscending dosePredictable pharmacokineticsSevoflurane anesthesiaPopulation pharmacokineticsSingle dosesTwitch heightPerioperative pulmonary thromboembolism
Ruohoniemi DM, Sista AK, Doany CF, Heerdt PM. Perioperative pulmonary thromboembolism. Current Opinion In Anaesthesiology 2018, 31: 75-82. PMID: 29206697, DOI: 10.1097/aco.0000000000000550.Peer-Reviewed Original ResearchConceptsSubmassive pulmonary emboliCatheter-directed therapyPulmonary emboliSystemic anticoagulationIntervention efficacyMean pulmonary artery pressurePerioperative pulmonary thromboembolismPulmonary artery pressureCurrent treatment optionsWarrants further investigationInadequacy of treatmentArtery pressurePulmonary thromboembolismPostoperative patientsPulmonary embolismRelative contraindicationSurgical patientsAggressive interventionIntraoperative embolizationPerioperative patientsTreatment optionsOptimizing therapyPromising efficacyElevated riskVentricular monitoring
2017
Accuracy of a Simulation Algorithm for Modelling LV Contractility, Diastolic Capacitance, and Energetics Using Data Available From Common Hemodynamic Monitors and Echocardiography
Heerdt PM, Korfhagen S, Ezz H, Oromendia C. Accuracy of a Simulation Algorithm for Modelling LV Contractility, Diastolic Capacitance, and Energetics Using Data Available From Common Hemodynamic Monitors and Echocardiography. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 381-388. PMID: 29153929, DOI: 10.1053/j.jvca.2017.09.032.Peer-Reviewed Original ResearchAnnexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases
Luo M, Flood EC, Almeida D, Yan L, Berlin DA, Heerdt PM, Hajjar KA. Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. Journal Of Experimental Medicine 2017, 214: 2535-2545. PMID: 28694388, PMCID: PMC5584111, DOI: 10.1084/jem.20160652.Peer-Reviewed Original ResearchConceptsAlveolar hypoxiaVascular endothelial cadherinMicrovascular integrityPulmonary edemaSrc homology phosphatase 2Vascular integrityEndothelial cellsVascular endothelial growth factorMicrovascular endothelial cellsEndothelial growth factorAdherens junction protein vascular endothelial cadherinEndothelial cadherinAirway obstructionNeutrophil infiltrationPulmonary microvasculatureAnnexin A2 functionsVascular leakLung parenchymaMice displayAltitude sicknessBarrier functionGrowth factorHypoxiaPhospholipid-binding proteinsProtein tyrosine phosphataseBridging the Educational Gap in Thoracic Anesthesia
Popescu WM, Heerdt PM. Bridging the Educational Gap in Thoracic Anesthesia. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 31: 1359-1360. PMID: 28800993, DOI: 10.1053/j.jvca.2017.05.021.Peer-Reviewed Original ResearchAnesthesia for nonintubated video-assisted thoracic surgery
Sunaga H, Blasberg JD, Heerdt PM. Anesthesia for nonintubated video-assisted thoracic surgery. Current Opinion In Anaesthesiology 2017, 30: 1-6. PMID: 27906718, DOI: 10.1097/aco.0000000000000413.Peer-Reviewed Original Research