Time Magazine 50 Best Inventions of 2010 for Engineered Lung, 2010.
Photo by Jamie Chung for Time
Petersen, T.H., Calle, E.A., Zhao, L., Lee, E.J., Gui, L., Raredon, M.B., Gavrilov, K., Yi, T., Zhuang, Z.W., Breuer, C., Herzog, E., and Niklason, L.E. Tissue-Engineered Lungs for in Vivo Implantation. Science. 329(5991): 538-41, 2010.
Yale University and Yale New Haven Medical Center are among the premier research and training institutions in the country. As part of this rich tradition, the areas of research interest in the department of Anesthesiology encompass both “traditional” areas of anesthesia research, and new areas of science and medicine. Expanding and enhancing the research mission in the department is one of the top priorities in Anesthesia at Yale.
Clinical research in Yale Anesthesia includes topics such as anesthesia patient safety and outcomes research. In addition, clinical studies of several novel agents that are active in the cardiovascular and coagulation systems are underway in the operating rooms and intensive care units. Furthermore, studies of peri-operative and post-operative outcomes and the impact of preoperative beta blockade, amongst other interventions, are being quantified and understood. Lastly, the impact of old age on anesthetic dosing requirements, intra-operatiave stability and peri-operative outcomes are being evaluated in the clinical setting.
Among topics being actively pursued by our faculty, we have basic research in the areas of basic neurobiology, as pertain to perception of pain, touch and itch. Research in these topics spans the gamut from whole animal studies (including human), to fundamental molecular approaches looking at the gene expression patterns of single neurons that are involved in sensation. This research program complements a variety of other research programs in Neurobiology at Yale having to do with the central nervous system.
Other faculty members study topics in vascular biology, as it pertains to peri-operative outcomes and sepsis, as well as stroke and the regeneration of blood vessels that are damaged by injury or disease. All of this work dovetails with various investigators in the Vascular Biology program at Yale. In addition, we are working on pioneering new strategies for regeneration of entire segments of functional lung, for the treatment of end-stage lung diseases such as emphysema and cystic fibrosis.
Looking at the practice of Anesthesia holistically, faculty members are studying the environmental impact of disposable items and exhausted gasses that are used in anesthetic practice, with a goal of mitigating environmental effects of these agents. These exciting areas of research, in addition to many others, are part of the Yale training and clinical experience. Working together, we’re breaking new ground and forging new links in science and medicine.