Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
About
Research
Publications
2026
Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis.
Liebrand M, Hamilton H, Roach B, Nicholas S, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Stone W, Walker E, Woods S, Cannon T, Koenig T, Mathalon D. Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis. JAMA Psychiatry 2026 PMID: 42234419, PMCID: PMC13234755, DOI: 10.1001/jamapsychiatry.2026.1084.Peer-Reviewed Original ResearchClinical high risk of psychosisClinical high riskConversion to psychosisHigh risk of psychosisClinical outcomesCHR-CCHR-NCRisk of psychosisHealthy controlsPrognostic biomarkerBiomarkers of clinical outcomesHC participantsMicrostate featuresClinical criteriaFollow-upMechanisms of illnessResting-state electroencephalographyTreatment decisionsPositive symptomsAuditory white noisePotential biomarkersCompensatory mechanismsMain OutcomesPsychosisOutcomesCannabis and tobacco co-use predicts psychosis in clinical high risk cohorts
Bello D, Blyth S, Rabin R, Addington J, Bearden C, Cadenhead K, Cannon T, Carrión R, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Brady R, Ward H. Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts. Nature Mental Health 2026, 4: 941-950. PMID: 42291778, PMCID: PMC13259916, DOI: 10.1038/s44220-026-00648-y.Peer-Reviewed Original ResearchConversion to psychosisPsychiatric symptom severityTobacco co-useCo-useCannabis usePsychiatric symptomsSymptom severityAssociated with psychiatric symptom severityClinical high-risk cohortRisk of conversion to psychosisLong-term psychiatric consequencesClinical high riskDevelopment of psychosisProspective study of individualsHealthy controlsTobacco useAssociated with higher riskHeavy cannabisCo-use of tobaccoCHR populationStudy of individualsAssociated with medical comorbiditiesPsychiatric consequencesPsychosisCannabisInternal monitoring deficits attenuate post-error slowing in psychosis-proneness
Zhao W, Cannon T. Internal monitoring deficits attenuate post-error slowing in psychosis-proneness. Schizophrenia Research Cognition 2026, 45: 100439. PMID: 42111504, PMCID: PMC13157023, DOI: 10.1016/j.scog.2026.100439.Peer-Reviewed Original ResearchPost-error slowingInternal performance monitoringPositive schizotypyPost-errorStudy 1Study 2Cognitive adjustmentError processPsychotic-like experiencesNon-decision timeCognitive resource allocationParanoid scalesPsychosis-pronenessFlanker taskPsychotic symptomsMonitoring deficitsMonitoring impairmentFalse feedbackPerformance monitoringFalse beliefsSchizotypyDrift-diffusion modelSelf-MonitoringFeedback conditionsBelief updating645. Cognitive Function and EEG Correlates in Clinical High-Risk for Psychosis: A Canonical Correlation Analysis of NAPLS2 Data
Hua J, Roach B, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Shapiro D, Woodberry K, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Stone W, Walker E, Woods S, Cannon T, Mathalon D. 645. Cognitive Function and EEG Correlates in Clinical High-Risk for Psychosis: A Canonical Correlation Analysis of NAPLS2 Data. Biological Psychiatry 2026, 99: s376. DOI: 10.1016/j.biopsych.2026.03.879.Peer-Reviewed Original Research631. Clinical and Neuroanatomical Variability Across Psychotic Diagnoses
Trevorrow Z, Chavannes A, Ferreira-Ianone S, Zhu J, Nuechterlein K, Asarnow R, Addington J, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Narr K, McEwen S, Ophoff R, Bearden C, Forsyth J. 631. Clinical and Neuroanatomical Variability Across Psychotic Diagnoses. Biological Psychiatry 2026, 99: s370. DOI: 10.1016/j.biopsych.2026.03.865.Peer-Reviewed Original ResearchLoss of Pyramidal Neuron Excitability is Present From the Prodrome in Psychosis, but may not be Common to All Subgroups Within the Psychosis Spectrum
Adams R, Hauke D, Rodriguez-Sanchez J, Oloye H, Parker D, Pearlson G, Keshavan M, Gershon E, Keedy S, Nicholas S, Hamilton H, Roach B, Investigators B, Investigators N, Woods S, Friston K, Pinotsis D, Cannon T, Clementz B, Tamminga C, Mathalon D. Loss of Pyramidal Neuron Excitability is Present From the Prodrome in Psychosis, but may not be Common to All Subgroups Within the Psychosis Spectrum. Biological Psychiatry 2026, 99: s15. DOI: 10.1016/j.biopsych.2026.03.045.Peer-Reviewed Original Research254. Long-Term (5-20-Year) Functional Profiles of Individuals at Clinical High-Risk (CHR) for Psychosis Across Age Groups: Variations in Life Events, Role, and Social Engagement
Kennedy L, Carrión R, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. 254. Long-Term (5-20-Year) Functional Profiles of Individuals at Clinical High-Risk (CHR) for Psychosis Across Age Groups: Variations in Life Events, Role, and Social Engagement. Biological Psychiatry 2026, 99: s208. DOI: 10.1016/j.biopsych.2026.03.488.Peer-Reviewed Original Research638. Internal Monitoring Deficits Undermine Post-Error Slowing in Psychosis-Proneness
Zhao W, Cannon T. 638. Internal Monitoring Deficits Undermine Post-Error Slowing in Psychosis-Proneness. Biological Psychiatry 2026, 99: s373. DOI: 10.1016/j.biopsych.2026.03.872.Peer-Reviewed Original Research629. Longitudinal Relationships Between Cannabis and Tobacco Use and Psychiatric Symptoms in Individuals at Clinical High-Risk for Psychosis
Bai Y, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Brady R, Carrion R, Ward H. 629. Longitudinal Relationships Between Cannabis and Tobacco Use and Psychiatric Symptoms in Individuals at Clinical High-Risk for Psychosis. Biological Psychiatry 2026, 99: s369. DOI: 10.1016/j.biopsych.2026.03.863.Peer-Reviewed Original ResearchBiophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome
Rodriguez-Sanchez J, Hauke D, Pinotsis D, Berndt L, Oloye H, Nicholas S, Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Friston K, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Adams R, Mathalon D. Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome. Biological Psychiatry 2026 PMID: 42025866, DOI: 10.1016/j.biopsych.2026.04.007.Peer-Reviewed Original ResearchPyramidal cell excitabilityP300 event-related potentialCell excitabilityPyramidal cellsMismatch negativityCHR-PAssociated with disinhibitionCompensatory downregulationDisinhibition of pyramidal cellsEvent-related potentialsPositive symptomsDownregulation of inhibitionP300 amplitude reductionCHR-P participantsInhibitory synaptic functionClinical high-risk syndromeTarget event-related potentialsHigh-risk syndromeSevere positive symptomsAuditory oddball paradigmAmplitude reductionConversion to psychosisClinical high riskSynaptic excitationExcitation/inhibition balance