1999
Implication of Tubby Proteins as Transcription Factors by Structure-Based Functional Analysis
Boggon T, Shan W, Santagata S, Myers S, Shapiro L. Implication of Tubby Proteins as Transcription Factors by Structure-Based Functional Analysis. Science 1999, 286: 2119-2125. PMID: 10591637, DOI: 10.1126/science.286.5447.2119.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlternative SplicingAmino Acid SequenceAnimalsCell LineCell NucleusCrystallography, X-RayDNAEye ProteinsHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsModels, MolecularMolecular Sequence DataProtein ConformationProtein Structure, SecondaryProtein Structure, TertiaryProteinsRecombinant ProteinsSequence AlignmentTranscription FactorsTranscriptional ActivationConceptsTubby-like proteinsTubby proteinTranscription factorsBipartite transcription factorDisease phenotypeMulticellular organismsProtein familyBiochemical functionsBiological functionsFunctional analysisStructural cluesCore domainUnique familyProteinGenetic mutationsTubbyPhenotypeRetinal degenerationFamilyMammalsOrganismsVital roleCrystal structureMutationsBroad range
1996
The Crystal Structure Analysis of d(CGCGAASSCGCG)2, a Synthetic DNA Dodecamer Duplex Containing Four 4′-Thio-2′-Deoxythymidine Nucleotides
Boggon T, Hancox E, McAuley-Hecht K, Connolly B, Hunter W, Brown T, Walker R, Leonard G. The Crystal Structure Analysis of d(CGCGAASSCGCG)2, a Synthetic DNA Dodecamer Duplex Containing Four 4′-Thio-2′-Deoxythymidine Nucleotides. Nucleic Acids Research 1996, 24: 951-961. PMID: 8600465, PMCID: PMC145717, DOI: 10.1093/nar/24.5.951.Peer-Reviewed Original ResearchConceptsDodecamer duplexCrystal structure analysisC1'-exo conformationC3'-exo conformationFine structural parametersCrystal structure refinementSugar-phosphate backboneSynthetic dodecamerWater moleculesDNA dodecamer duplexAnalogous sugarsStructure analysisStructure refinementNative dodecamerConformationDodecamerStructural parametersDuplexDeoxythymidine nucleotidesStructureThiosugarsBackboneMoleculesNucleosidesSynthetic