Mina Kojima, PhD
Associate Research ScientistCards
About
Research
Publications
2024
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu B, Lucca L, Lewis W, Wang J, Nogueira C, Heer S, Rayon-Estrada V, Axisa P, Reeves S, Buitrago-Pocasangre N, Pham G, Kojima M, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski J, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle A, Kisielow J, Obermair F, Kluger H, Hafler D. Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma. Nature Immunology 2024, 26: 82-91. PMID: 39609626, DOI: 10.1038/s41590-024-02023-4.Peer-Reviewed Original ResearchCD8+ T cellsAnti-tumor immunityRegulatory T cellsT cellsSubpopulation of CD8+ T cellsCytotoxic CD8+ T cellsHuman CD8+ T cellsTumor antigen-specific CD8Impaired anti-tumor immunityTumor antigen-specificPoor overall survivalTumor rejectionKIR expressionOverall survivalTumor antigensImmune evasionCellular mediatorsHuman cancersCD8MelanomaTumorTranscriptional programsFunctional heterogeneityImmunityPatientsThe maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus
Kojima M, Hoppe C, Giraldez A. The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus. Nature Reviews Genetics 2024, 26: 245-267. PMID: 39587307, PMCID: PMC11928286, DOI: 10.1038/s41576-024-00792-0.Peer-Reviewed Original Research
2022
The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
Miao L, Tang Y, Bonneau AR, Chan SH, Kojima ML, Pownall ME, Vejnar CE, Gao F, Krishnaswamy S, Hendry CE, Giraldez AJ. The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell 2022, 82: 986-1002.e9. PMID: 35182480, PMCID: PMC9327391, DOI: 10.1016/j.molcel.2022.01.024.Peer-Reviewed Original ResearchConceptsGenome activationChromatin openingTranscription factorsPioneer factor activityDifferent transcription factorsChromatin reprogrammingPioneer factorsNucleosome positionsActive enhancersIndividual genesCore histonesTriple mutantGene activationTF inputsDevelopmental transitionsSequence contextCell typesFactor activityHistonesPioneering activityEnhancerActivationSequence of eventsPou5f3Chromatin
2019
Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
Kojima M, de Rooij D, Page D. Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice. ELife 2019, 8: e43738. PMID: 30810530, PMCID: PMC6392498, DOI: 10.7554/elife.43738.Peer-Reviewed Original ResearchConceptsInitiation of meiosisMeiotic cell cycleMeiotic initiationTranscriptional programsCell cycleGerm cell-specific genesG1-S cell cycle transitionCell-specific genesCell cycle transitionGene expression programsMulticellular organismsTranscriptional networksDNA replicationGerm lineRobust amplificationMeiosis I.G1-SGenesExpression programsMeiosisStra8GermAmplificationMiceCells
2018
Corrigendum to “Isolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting” [Dev. Biol. 443 (2018) 19–34]
Romer K, de Rooij D, Kojima M, Page D. Corrigendum to “Isolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting” [Dev. Biol. 443 (2018) 19–34]. Developmental Biology 2018, 445: 113. PMID: 30416000, DOI: 10.1016/j.ydbio.2018.10.021.Peer-Reviewed Original ResearchIsolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting
Romer K, de Rooij D, Kojima M, Page D. Isolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting. Developmental Biology 2018, 443: 19-34. PMID: 30149006, DOI: 10.1016/j.ydbio.2018.08.009.Peer-Reviewed Original ResearchConceptsGerm cellsUndifferentiated spermatogoniaMeiotic phase of spermatogenesisPopulations of male germ cellsSomatic cellsGerm cell development in vivoPhase of spermatogenesisContaminating somatic cellsMale germ cellsMeiotic germ cellsGerm cell typesRetinoic acid metabolismFluorescence-activated cell sortingCell sorting methodIsolated discrete populationsAdult testisMouse testisMeiotic phaseMeiotic prophaseBiochemical studiesDevelopmental synchronizationAcid metabolismDevelopment in vivoCell typesCell sorting
2017
Meioc maintains an extended meiotic prophase I in mice
Soh Y, Mikedis M, Kojima M, Godfrey A, de Rooij D, Page D. Meioc maintains an extended meiotic prophase I in mice. PLOS Genetics 2017, 13: e1006704. PMID: 28380054, PMCID: PMC5397071, DOI: 10.1371/journal.pgen.1006704.Peer-Reviewed Original ResearchConceptsMeiotic prophase IProphase IGerm cellsMeiotic cell cycle programPre-meiotic DNA replicationProphase of mitosisProtein pull-downMeiosis-specific chromosome eventsCell cycle programPost-transcriptional controlFemale germ cellsMitotic spermatogoniaMEIOCHomologous pairingDNA replicationTarget transcriptsChromosomal programMeiotic prophaseZygotene stageExpressed proteinsCyclin A2Pull-downGerm-cellTranscriptionProphase
Academic Achievements & Community Involvement
News
Get In Touch
Contacts
Email