Euripedes C. Miguel, MD, PhD
Professor & Chair of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo School of MedicineAbout
Titles
Professor & Chair of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo School of Medicine
Biography
Dr. Miguel is currently Professor & Chair of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo School of Medicine (USP). Through a network of professional associations established in the last decades, Eurípedes Miguel set up productive partnerships with the major university centers in the world, recently being appointed Adjunct Associate Professor of the Department of Psychiatry and Behavioral Sciences of the Duke University Medical Center, Adjunct Associate Professor of the Yale Child Study Center, Yale University School of Medicine and Consultant in Research at the Massachusetts General Hospital, Harvard Medical School. He was the founder and coordinator of the Obsessive-Compulsive Spectrum Disorders Program of the Institute of Psychiatry at USP (1994-2009) and is now the Coordinator of the National Institute for Developmental Psychiatry (www.inpd.org.br) focused on preventive measures for Children and Adolescents.
Appointments
Child Study Center
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- Harvard Medical School, Massachusetts General Hospital (1994)
- PhD
- University of São Paulo, Psychiatry Department (1992)
- MD
- University of Sao Paulo Medical School (1982)
Research
Overview
- Comorbidities Trajectory in Obsessive-Compulsive Disorder
- Neural Circuits and Biological Markers Involved in Obsessive-Compulsive Behavior by Paradigms of Fear and Anxiety
- National Institute of Science and Technology Developmental Psychiatry for Children and adolescents
- A Multicenter Sequential Multiple Assignment Randomized Trial (SMART) for children with OCD
- Scholar High risk cohort study for the development of psychopathology and resilience – PREVENTION Study
- Butantã (SP) Birth Cohort
- Pregnant Women Cohort Study
Medical Research Interests
Public Health Interests
ORCID
0000-0002-9393-3103
Research at a Glance
Yale Co-Authors
Publications Timeline
James Leckman, MD, PhD
Thomas Fernandez, MD
Michael Bloch, MD, MS
Christopher Pittenger, MD, PhD
Catherine Panter-Brick
Michael Stevens, PhD
Publications
2025
Beyond Technique: The Phenomenology of Care in Medical Practice During the COVID-19 Pandemic—A Qualitative Study
Guimarães-Fernandes F, de Oliveira L, Neto P, Feniman D, Correia A, de Oliveira Bosoni N, Macaya D, Miguel E, Ceron-Litvoc D, Castellana G. Beyond Technique: The Phenomenology of Care in Medical Practice During the COVID-19 Pandemic—A Qualitative Study. The Humanistic Psychologist 2025, 53: 102-120. DOI: 10.1037/hum0000335.Peer-Reviewed Original ResearchConceptsCare to COVID-19 patientsLimits of knowledgeMedical practiceHealth care professionalsHealth care practitionersHeidegger’s philosophyExistential questionsExperience of griefCare professionalsResident physiciansCare practitionersPhysician's roleSemistructured interviewsQualitative studyPhysiciansLived experienceCareCOVID-19InterviewsPhilosophyProfessional developmentCoronavirus disease 2019PhenomenologyEducational aspectsEveryday routinesImpact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study
Ota V, Oliveira A, Bugiga A, Conceição H, Galante P, Asprino P, Schäfer J, Hoffmann M, Bressan R, Brietzke E, Manfro G, Grassi-Oliveira R, Gadelha A, Rohde L, Miguel E, Pan P, Santoro M, Salum G, Carvalho C, Belangero S. Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study. Frontiers In Psychiatry 2025, 16: 1505421. PMID: 40018685, PMCID: PMC11866055, DOI: 10.3389/fpsyt.2025.1505421.Peer-Reviewed Original ResearchConceptsBrazilian High-Risk Cohort StudyChild Behavior ChecklistHigh Risk Cohort StudyLife adversityPsychiatric symptomsExternalizing symptomsDevelopment of psychiatric symptomsAssociated with depressive symptomsEarly life adversityStressful life eventsAssociated with psychiatric phenotypesPsychiatric phenotypesBehavior ChecklistDepressive symptomsLife eventsMental disordersPsychopathologyNo mediationChild maltreatmentCohort studyLatent factorsAssociated with deprivationAdversityModerating effectMental conditionA Preliminary Investigation of Associations Between Traumatic Events Experienced During Pregnancy and Salivary Diurnal Cortisol Levels of Brazilian Adolescent Mothers and Infants
Wiley K, Gouveia G, Camilo C, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. A Preliminary Investigation of Associations Between Traumatic Events Experienced During Pregnancy and Salivary Diurnal Cortisol Levels of Brazilian Adolescent Mothers and Infants. American Journal Of Human Biology 2025, 37: e70004. PMID: 39905640, DOI: 10.1002/ajhb.70004.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLifetime trauma exposureSalivary diurnal cortisolTrauma exposureTraumatic eventsDiurnal cortisolAdolescent mothersEvening cortisolCortisol levelsExposure to traumatic eventsHome visiting interventionInterpersonal violenceAssaultive violence exposureMaternal trauma historyBedtime cortisol levelsExperiences of interpersonal violenceEvening cortisol levelsTrauma history variablesIntergenerational transmission of traumaCohort of adolescent mothersBrazilian adolescent mothersModel of fetal programmingMorning cortisol levelsStudy investigated associationsTransmission of traumaIntervention groupLetter in response to Matos e Souza et al.
Damiano R, Beiram L, Damiano B, Miguel E, Menezes P, Salum G. Letter in response to Matos e Souza et al. Journal Of Affective Disorders 2025, 374: 235-237. PMID: 39798716, DOI: 10.1016/j.jad.2025.01.034.Peer-Reviewed Original ResearchCopy Number Variations in the Brazilian High-Risk Cohort for Mental Conditions.
Arendt J, Zamariolli M, Almodobar L, Ito L, Ormond R, Oliveira A, Ota V, Rohde L, Miguel E, Pan P, Bressan R, Salum G, Belangero S, Santoro M. Copy Number Variations in the Brazilian High-Risk Cohort for Mental Conditions. Brazilian Journal Of Psychiatry 2025 PMID: 40014503, DOI: 10.47626/1516-4446-2024-3765.Peer-Reviewed Original ResearchConceptsCopy number variationsDatabase of Genomic VariantsNumber variationsMental health disordersCopy number variation studiesImpact of copy number variationsGenome Aggregation DatabasePennCNV softwareGenomic variantsGenetic variantsAggregation DatabaseAssociated with mental health disordersDevelopment of mental health disordersHigh-risk cohortInheritance patternMental conditionBrazilian High-Risk Cohort StudyHigh Risk Cohort StudyMild effect sizeCohort studyBrazilian cohortCopyHealth disordersDuplicationMeta-analysis
2024
Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross‐country study using retrospective harmonisation
Moltrecht B, do Amaral J, Salum G, Miguel E, Rohde L, Ploubidis G, McElroy E, Hoffmann M. Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross‐country study using retrospective harmonisation. Journal Of Child Psychology And Psychiatry 2024 PMID: 39644141, DOI: 10.1111/jcpp.14080.Peer-Reviewed Original ResearchConceptsMillennium Cohort StudySocial connectivity factorsBrazilian High-Risk Cohort StudyExternalising difficultiesMarital statusInternalising symptomsGlobal mental health effortCohort studyYoung people's mental healthExternalising symptomsMental health effortsUK Millennium Cohort StudyHigh Risk Cohort StudyPeople's mental healthSocial connection variablesMother's marital statusHealth effortsMental healthUnited KingdomSocioeconomic factorsPopulation representativeHousehold sizeSurvey designMother-child relationshipTest measurement invarianceEnhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design
Duarte I, Hoffmann M, Salum G, Leffa D, Belangero S, Santoro M, Ota V, Ito L, Pan P, Farhat L, Murray A, Miguel E, Kieling C, Rohde L, Caye A. Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 39625683, DOI: 10.1007/s00787-024-02622-4.Peer-Reviewed Original ResearchConceptsNeurobiological measuresADHD polygenic scoresBrazilian High-Risk CohortAttention-deficit/hyperactivity disorderPoorer executive functionPolygenic scoresADHD symptomsExecutive functionHigh-risk subgroupsAttention-deficit/hyperactivitySubcortical volumesHigh-risk cohortMental disordersADHD casesEffect sizeADHDMental conditionDifferential riskClinical practiceRisk cohortBiomarkers to clinical practiceLow-risk groupCalculated riskParticipantsAdolescentsChildhood maltreatment and the structural development of hippocampus across childhood and adolescence
Doretto V, Salto A, Schivoletto S, Zugman A, Oliveira M, Brañas M, Croci M, Ito L, Santoro M, Jackowski A, Bressan R, Rohde L, Salum G, Miguel E, Pan P. Childhood maltreatment and the structural development of hippocampus across childhood and adolescence. Psychological Medicine 2024, 54: 4528-4536. PMID: 39773537, PMCID: PMC11769901, DOI: 10.1017/s0033291724001636.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentRight hippocampal volumeHippocampal volumeDepressive disorderCommunity sampleReduced right hippocampal volumeExposure to childhood maltreatmentReduction of hippocampal volumeLongitudinal studyMagnetic resonance imagingPolygenic risk scoresHippocampal structureParent reportLate childhoodSelf-reportMaltreatmentVolumetric developmentAdolescentsHippocampalChildhoodAged 6Brain magnetic resonance imagingDisordersDevelopment of hippocampusResonance imagingEstimating the Economic Impacts for Caregivers of Young People With Mental Health Problems in a Brazilian Cohort
Ziebold C, McDaid D, King D, Romeo R, Ribeiro W, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Evans-Lacko S. Estimating the Economic Impacts for Caregivers of Young People With Mental Health Problems in a Brazilian Cohort. Value In Health 2024, 28: 336-347. PMID: 39477147, DOI: 10.1016/j.jval.2024.10.3802.Peer-Reviewed Original ResearchConceptsCaregivers of young peopleMental health problemsHealth problemsService usePersonal mental health problemsYoung peopleCosts of productivity lossOut-of-pocket expensesMental health issuesHousehold tasksBrazilian cohortLogistic regression modelsCaregiver characteristicsHealthcare utilisationFemale caregiversSocioeconomic groupsCaregiversTargeted policy interventionsHealth issuesGeneralised linear modelsProductivity lossHigh impairmentAssess productivity lossRegression modelsEconomic impactAuthor Correction: Obsessive–compulsive disorder
Stein D, Costa D, Lochner C, Miguel E, Reddy Y, Shavitt R, van den Heuvel O, Simpson H. Author Correction: Obsessive–compulsive disorder. Nature Reviews Disease Primers 2024, 10: 79. PMID: 39414819, DOI: 10.1038/s41572-024-00569-z.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity São Paulo University
Public ServiceProfessorDetailsProfessor of Psychiatry2009 - Presentactivity São Paulo University
Public ServiceChairpersonDetailsChairman on Department of Psychiatry of Medical School in São Paulo University.12/01/2009 - Presentactivity São Paulo University
Public ServiceProfessorDetailsProfessor of Psychiatry, Department of Psychiatry, University of São Paulo Medical School2009 - Presentactivity Developmental Psychiatry National Institute for Children and Adolescent
Professional OrganizationsPresidentDetailsPresident National Institute for Developmental Psychiatry01/12/2009 - Presentactivity Institute of Psychiatry
CommitteesMemberDetailsMember, Executive Committee of Institute of Psychiatry, University of São Paulo2009 - Present