Dil (Dilrukshi) Ekanayake-Alper, DVM, PhD, DACLAM
Assistant ProfessorDownloadHi-Res Photo
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Appointments
Comparative Medicine
Primary
Additional Titles
Assistant Director, Residency Training Program, Department of Comparative Medicine
About
Titles
Assistant Professor
Assistant Director, Residency Training Program, Department of Comparative Medicine
Appointments
Comparative Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Laboratory Animal Residency
- Yale School of Medicine (2015)
- Veterinary Internship
- Louisiana State University (2012)
- PhD
- University of Georgia, Molecular Biology and Biochemistry (2011)
- Global Infectious Disease Scholar
- Marine Biology Laboratory (2006)
- DVM
- University of Peradeniya (2003)
Board Certifications
Laboratory Animal Medicine
- Certification Organization
- American College of Laboratory Animal Medicine
- Original Certification Date
- 2016
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Dil (Dilrukshi) Ekanayake-Alper's published research.
Publications Timeline
A big-picture view of Dil (Dilrukshi) Ekanayake-Alper's research output by year.
Alvaro Duque, PhD
Angus Nairn, PhD
Christopher van Dyck, MD
Daniel Holden
Juan Arellano, PhD
Li Wen, MD, PhD
26Publications
44Citations
Publications
2024
Durable Mixed Chimerism May Permit Subsequent Immunosuppression-Free Intestinal Transplantation - a Proof-of-Principle Study.
Patwardhan S, Gunes ME, Manell E, Hong J, Jordache P, Chauhan I, Almesallmy A, Mulder H, Ekanayake-Alper D, Hajosi D, Ko HM, Sanmugarajah K, Cetrulo CL, Nowak G, Sachs DH, Sykes M, Weiner J. Durable Mixed Chimerism May Permit Subsequent Immunosuppression-Free Intestinal Transplantation - a Proof-of-Principle Study. Am J Transplant 2024 PMID: 39442670, DOI: 10.1016/j.ajt.2024.10.014.Peer-Reviewed Original ResearchDevelopment of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes
1. Merl, S., Chen, B., Gunes, M. E., Atta, H., Yang, K., Ekanayake-Alper, D., Hajosi, D., Huang, F., Bhola, B., Patwardhan, S., Jordache, P., Nowak, G., Kato, T., Sykes, M., Yamada, K., & Weiner, J. (2024). Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes. Frontiers in Transplantation, Section Transplantation Immunology, 3, 1367486Peer-Reviewed Original ResearchSedation Efficacy of Midazolam in Conjunction with Ketamine and Alfaxalone in Female Laboratory Guinea Pigs (Cavia porcellus).
Wharton KN, Walsh CA, Haulter M, Ekanayake D, Ekanayake-Alper D. Sedation Efficacy of Midazolam in Conjunction with Ketamine and Alfaxalone in Female Laboratory Guinea Pigs (Cavia porcellus). J Am Assoc Lab Anim Sci 2024 PMID: 39074958, DOI: 10.30802/AALAS-JAALAS-24-000028.Peer-Reviewed Original ResearchDevelopment of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes.
Merl S, Chen B, Gunes ME, Atta H, Yang K, Ekanayake-Alper D, Hajosi D, Huang F, Bhola B, Patwardhan S, Jordache P, Nowak G, Martinez M, Kato T, Sykes M, Yamada K, Weiner J. Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes. Front Transplant 2024, 3: 1367486. PMID: 38993771, DOI: 10.3389/frtra.2024.1367486.Peer-Reviewed Original ResearchA Comparison of Three Anesthetic Drug Combinations for Use in Inducing Surgical Anesthesia in Female Guinea Pigs (Cavia porcellus).
Avelino JA, Walsh CA, Wharton KN, Ekanayake D, Ekanayake-Alper D. A Comparison of Three Anesthetic Drug Combinations for Use in Inducing Surgical Anesthesia in Female Guinea Pigs (Cavia porcellus). J Am Assoc Lab Anim Sci 2024, 63: 182-189. PMID: 38182132, DOI: 10.30802/AALAS-JAALAS-23-000064.Peer-Reviewed Original Research
2023
Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
Bathla S, Datta D, Liang F, Barthelemy N, Wiseman R, Slusher B, Asher J, Zeiss C, Ekanayake‐Alper D, Holden D, Terwilliger G, Duque A, Arellano J, van Dyck C, Bateman R, Xie Z, Nairn A, Arnsten A. Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12431. PMID: 37915375, PMCID: PMC10617575, DOI: 10.1002/trc2.12431.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSporadic Alzheimer's diseaseEntorhinal cortexGCPII inhibitionDorsolateral prefrontal cortexChronic inhibitionTau pathologyTau hyperphosphorylationAged macaquesType 3 metabotropic glutamate receptorAlzheimer's diseasePrefrontal cortexRhesus macaquesVehicle-treated monkeysAged rhesus macaquesMetabotropic glutamate receptorsApparent side effectsAmyloid beta 1Regulation of calciumGCPII inhibitorsKey etiological factorGCPII activityPrimate dlPFCNeuronal damageCSF analysisCalcium dysregulation
2021
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig-to-baboon xenotransplantation.
Takeuchi K, Ariyoshi Y, Shimizu A, Okumura Y, Cara-Fuentes G, Garcia GE, Pomposelli T, Watanabe H, Boyd L, Ekanayake-Alper DK, Amarnath D, Sykes M, Sachs DH, Johnson RJ, Yamada K. Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig-to-baboon xenotransplantation. Xenotransplantation 2021, 28: e12708. PMID: 34418164, DOI: 10.1111/xen.12708.Peer-Reviewed Original ResearchAntibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons.
Ariyoshi Y, Takeuchi K, Pomposelli T, Ekanayake-Alper DK, Shimizu A, Boyd L, Estime E, Ohta M, Asfour A, Scott Arn J, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons. Xenotransplantation 2021, 28: e12642. PMID: 32909301, DOI: 10.1111/xen.12642.Peer-Reviewed Original Research
2020
Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques.
Alonso-Guallart P, Duran-Struuck R, Zitsman JS, Sameroff S, Pereira M, Stern J, Berglund E, Llore N, Pierre G, Lopes E, Kofman SB, Danton M, Sondermeijer HP, Woodland D, Kato Y, Ekanayake-Alper DK, Iuga AC, Wuu CS, Wu A, Lipkin WI, Tokarz R, Sykes M, Griesemer A. Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques. Transplantation 2020, 104: 270-279. PMID: 31385931, DOI: 10.1097/TP.0000000000002893.Peer-Reviewed Original ResearchSafety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques - an experimental study.
Berglund E, Alonso-Guallart P, Danton M, Sellberg F, Binder C, Fröbom R, Berglund D, Llore N, Sakai H, Iuga A, Ekanayake-Alper D, Reimann KA, Sachs DH, Sykes M, Griesemer A. Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques - an experimental study. Transpl Int 2020, 33: 98-107. PMID: 31523849, DOI: 10.1111/tri.13524.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity University Research Council, University Of Peradeniya, Sri Lanka
Peer Review Groups and Grant Study SectionsGrant ReviewerDetails2023 - Presentactivity Journal of American Association of Laboratory Animal Science
Journal ServiceReviewerDetails2021 - Presentactivity Journal of Virology
Journal ServiceReviewerDetails2020 - Presentactivity Journal of Visualized Experiment
Journal ServiceReviewerDetails2017 - Presentactivity American College of Laboratory Animal Medicine
Professional OrganizationsMemberDetails2016 - Present
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