About
Titles
Instructor
Biography
I am a physician-scientist track candidate in the Department of Pathology, with fellowship training in both cytopathology and molecular pathology. I am currently a post-doc in Don Nguyen's laboratory, studying how lung carcinoma metastasizes to the central nervous system.
Appointments
Pathology
InstructorPrimary
Other Departments & Organizations
- Janeway Society
- Nguyen Lab
- Pathology
- Yale Medicine
Education & Training
- Fellow, Cytopathology
- Yale New Haven Hospital (2023)
- Fellow, Molecular Genetic Pathology
- Yale New Haven Hospital (2022)
- Chief Resident, Anatomic and Clinical Pathology
- Yale New Haven Hospital (2021)
- Resident, Anatomic and Clinical Pathology
- Yale New Haven Hospital (2020)
- MD/PhD
- Upstate Medical University (2017)
- BS
- Cornell University (2006)
Board Certifications
Cytopathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2023
Molecular Genetic Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2022
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2022
Research
Overview
The goal of one ongoing research project, which is supported by an intradepartmental Chair’s Challenge grant, is to detect driver and resistance mutations in pleural fluid-derived circulating tumor DNA from patients with lung adenocarcinoma. The aim of this project is to use an error-suppressed multiplex deep sequencing platform, originally designed to detect low abundance tumor-specific mutations in plasma, to detect mutations with high sensitivity in the supernatants of malignant pleural effusions.
Research at a Glance
Yale Co-Authors
Frequent collaborators of Darin Dolezal's published research.
Anna Arnal Estape, PhD, BS
Declan McGuone, FRCPath Neuro, MBBCh
Don Nguyen, PhD
Guoping Cai, MD, MS
Malini Harigopal, MD
Nicholas Blondin, MD
Publications
2024
BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE
Kandigian S, Chande S, Dolezal D, Tang T, Wang D, Arnal-Estapé A, Cheok S, McGuone D, Liu Y, Goldberg S, Blondin N, Chiang V, Nguyen D. BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE. Neuro-Oncology Advances 2024, 6: i7-i7. PMCID: PMC11296776, DOI: 10.1093/noajnl/vdae090.020.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerLeptomeningeal diseaseCentral nervous systemLeptomeningeal metastasesParenchymal metastasesCerebrospinal fluidTumor cellsTyrosine kinase inhibitor treatmentCell lung cancerKinase inhibitor treatmentCerebrospinal fluid of patientsCell linesCerebral lateral ventriclesIntra-arterial injectionTGF-b signalingIn vivo passageIntraparenchymal diseaseMechanisms of progressionTumor microenvironmentMultiplex immunofluorescenceAggressive treatmentLeptomeningeal infiltrationPerivascular invasionIntraparenchymal metastasesMurine modelThe World Health Organization Reporting System for Lung Cytopathology–A Review of the First Edition
Dolezal D, Kholová I, Cai G. The World Health Organization Reporting System for Lung Cytopathology–A Review of the First Edition. Journal Of Clinical And Translational Pathology 2024, 4: 18-35. PMID: 38736711, PMCID: PMC11086742, DOI: 10.14218/jctp.2023.00068.Peer-Reviewed Original ResearchConceptsClinical management recommendationsRisk of malignancyCytomorphologic criteriaLung cytopathologyImprove patient careAncillary testsEstimated risk of malignancyReporting SystemDiagnostic categoriesPatient carePotential diagnostic pitfallsGroup of lesionsPractice settingsManagement recommendationsPractice recommendationsDiagnostic pitfallsEstimated riskCytopathology specimensCytopathology practiceLungCytopathologyLesionsMalignancyCytopathologistsSpecimen types
2023
Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review
Carrasco-Tenezaca F, Moreira-Dinzey J, Manrai P, Bearse M, Burela S, Podany P, Singh K, Pareja F, Zheng J, Muscato N, Liang Y, Zhan H, Krishnamurti U, Dolezal D, Wang J, Harigopal M. Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. International Journal Of Surgical Pathology 2023, 32: 1037-1045. PMID: 37908113, DOI: 10.1177/10668969231209780.Peer-Reviewed Original ResearchConceptsBreast carcinomaTubulopapillary featuresHuman epidermal growth factor 2 (HER2) expressionBreast cancer histologic subtypesNonmetastatic breast carcinomaTriple-negative profileHigh-grade nuclear featuresTriple-negative carcinomasHigh-grade featuresMetastatic breast carcinomaGrowth factor 2 expressionFactor 2 expressionReports of tumorsMicropapillary projectionsNeoadjuvant therapyHistologic subtypeWorse prognosisFirst tumorPoor prognosisAdditional tumorsInvasive carcinomaEstrogen receptorCarcinomaPathogenic variantsTumorsS2209 Pancreatic Insulinoma: A Hidden Challenge
Mathialagan K, Dolezal D, Nagar A. S2209 Pancreatic Insulinoma: A Hidden Challenge. The American Journal Of Gastroenterology 2023, 118: s1585-s1585. DOI: 10.14309/01.ajg.0000958476.17153.c1.Peer-Reviewed Original Research