Bao-Zhu Yang, PhD
Research Scientist in PsychiatryDownloadHi-Res Photo
Cards
Appointments
Psychiatry
Primary
Contact Info
Psychiatry
300 George St
New Haven, CT 06511-
United States
About
Titles
Research Scientist in Psychiatry
Appointments
Psychiatry
Research ScientistPrimary
Other Departments & Organizations
- Division of Human Genetics
- Gelernter Lab
- Psychiatry
- Psychology Section
- Yale Ventures
Education & Training
- PhD
- university at Albany (2001)
Research
Overview
My research focus in the past few years includes investigation of issues related to population stratification for case control association studies, structured association analysis, gene-environment interaction, haplotype analysis, and admixture mapping, and applied these analytical methods in finding genetic bases of psychiatric disorders such as childhood depression, alcoholism, drug dependence, nicotine dependence, post traumatic stress disorder. Currently, I devote myself to mapping genes for comorbidity of substance use disorders and depression using linkage and association methods under the support of an NIH K01 career development award.
Mapping genes for comorbidity of substance used disorders and depressionCandidate gene association study on PTSD
Medical Research Interests
Alcoholism; Behavior and Behavior Mechanisms; Depression; Epidemiology; Mental Disorders; Models, Statistical; Psychiatry and Psychology; Stress Disorders, Post-Traumatic
Research at a Glance
Yale Co-Authors
Frequent collaborators of Bao-Zhu Yang's published research.
Publications Timeline
A big-picture view of Bao-Zhu Yang's research output by year.
Research Interests
Research topics Bao-Zhu Yang is interested in exploring.
Joel Gelernter, MD
Yaira Zoé Núñez
Hang Zhou, PhD
Xingguang Luo, MD
Hongyu Zhao, PhD
John Krystal, MD
41Publications
1,942Citations
Alcoholism
Stress Disorders, Post-Traumatic
Depression
Publications
2024
Nerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits
Kuo S, Lin C, Tsou C, Yeh Y, Yang B, Chen C, Huang C, Huang S. Nerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits. European Archives Of Psychiatry And Clinical Neuroscience 2024, 1-12. PMID: 39311999, DOI: 10.1007/s00406-024-01906-9.Peer-Reviewed Original ResearchConceptsTridimensional Personality QuestionnairePersonality traitsHeroin dependenceHarm avoidanceBarratt Impulsiveness Scale version 11Tridimensional Personality Questionnaire scoresTrait of impulsivityAssociated with heroin dependenceChinese versionBIS-11Reward processingPersonality QuestionnaireAssociated with traitsFemale HD patientsNeurotrophic factors nerve growth factorFemale subgroupPotential confounding effectsHD patientsGenetic contributionPersonsTraitsCo-occurrenceGene polymorphismsVersion 11Confounding effectsNeurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampus
2023
F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK
Zhou H, Yang B, Kranzler H, Gelernter J. F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK. European Neuropsychopharmacology 2023, 75: s274. DOI: 10.1016/j.euroneuro.2023.08.480.Peer-Reviewed Original ResearchConceptsInverse variance weightingAlcohol useCancer riskOral/pharyngeal cancerOral cancer riskMendelian randomizationMendelian randomization analysisCumulative epidemiological evidenceSpecific cancer typesDevelopment of cancerPharyngeal cancerEsophageal cancerEpidemiological evidenceProblematic alcohol useAlcohol consumptionUnderreported populationCancerCancer typesMR studiesMR-PRESSOAlcohol-related phenotypesDifferent cancersRandomization analysisBreastMR-EggerDifferences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder
He L, Yang B, Ma Y, Wen L, Liu F, Zhang X, Liu T. Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder. Frontiers In Cellular And Infection Microbiology 2023, 13: 1103919. PMID: 36909722, PMCID: PMC9996337, DOI: 10.3389/fcimb.2023.1103919.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMA use disorderClinical featuresGut microbiotaWithdrawal symptomsMA usersEnterotype 2Use disordersGM diversityBody mass indexMethamphetamine use disorderSemi-Structured AssessmentMass indexNeuropsychiatric symptomsHigh incidenceDiagnostic criteriaDifferential microbesDistinct enterotypesDrug dependenceGM differencesSymptomsClinical traitsPerformed network analysisStrong cravingsFecal samplesFurther studies
2021
Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
Ma YJ, Wang YY, Liu MQ, Fang T, Wei ZR, Chen SB, Tan H, Nunez YZ, Zhang XJ, Hao W, Malison RT, Kranzler HR, Gelernter J, Liu TQ, Yang BZ. Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug And Alcohol Dependence 2021, 229: 109047. PMID: 34710713, DOI: 10.1016/j.drugalcdep.2021.109047.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference
Yang C, Fu X, Hao W, Xiang X, Liu T, Yang B, Zhang X. Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference. Addiction Biology 2020, 26: e12975. PMID: 33094505, DOI: 10.1111/adb.12975.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMA use disorderGut microbiota compositionGut dysbiosisUse disordersGut microbiotaCPP scoresMicrobiota compositionHigher CPP scoresSusceptible riskRibosomal RNA sequencingCPP trainingRat modelSame doseDrug effectsPlace preferencePotent stimulantDysbiosisRats' responsesImportant modulatorCumulative evidenceRatsLow CPPMethamphetamineDisordersCPPGABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals
Yang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals. Addictive Behaviors 2020, 114: 106695. PMID: 33153773, PMCID: PMC8299472, DOI: 10.1016/j.addbeh.2020.106695.Peer-Reviewed Original ResearchCitationsDiagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version
Yang BZ, Wang LJ, Huang MC, Wang SC, Tsai MC, Huang YC, Nuñez YZ, Ng MH, Kranzler HR, Gelernter J, Chen CK. Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version. Complex Psychiatry 2020, 6: 62-67. PMID: 34882761, PMCID: PMC7923924, DOI: 10.1159/000511606.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSD diagnosisSemi-Structured AssessmentTest-retest reliabilityDependence diagnosisDrug dependenceΚ statisticDiagnostic reliabilityStructured Clinical InterviewCohen κ statisticChance-corrected agreementClinician versionSubstance dependence diagnosesNicotine dependencePsychiatric disordersClinical InterviewAlcohol dependenceDSM-IVDiagnosisSubstance useChinese versionOpioidsValid instrumentConcurrent validityKetamineMethamphetamineTubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children
de Araújo CM, Hudziak J, Crocetti D, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Yang BZ, Mostofsky S, Jackowski A, Lee RS, Gelernter J, Kaufman J. Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children. Psychiatry Research Neuroimaging 2020, 298: 111058. PMID: 32120304, PMCID: PMC11079625, DOI: 10.1016/j.pscychresns.2020.111058.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStress-related psychiatric disordersCorpus callosum measuresFractional anisotropyPsychiatric disordersTrauma experiencesWhite matter tractsChild trauma experiencesBrain changesLarger studyRelevant covariatesAtlas-based approachSplenium fractional anisotropyDNA specimensMultiple comparisonsGene methylationDisordersChildrenCurrent study
2019
Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans
Yang BZ, Zhou H, Cheng Z, Kranzler HR, Gelernter J. Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. Scientific Reports 2019, 9: 18070. PMID: 31792237, PMCID: PMC6889277, DOI: 10.1038/s41598-019-53560-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAllelesAnalgesics, OpioidBlack or African AmericanBrainCalcium-Binding ProteinsFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, G-Protein-CoupledReceptors, Kainic AcidSex FactorsWhite PeopleConceptsOpioid dependenceOD riskSex-different effectsSex differencesInferior olivary nucleusDSM-IV diagnosisDimorphic riskSubstantia nigraAA menOlivary nucleusFrontal cortexEuropean-American subjectsADGRV1Further studiesRiskAfrican AmericansGenetic variantsDisease enrichment analysisBrainSex interactionNominal significanceMenFirst studyPutamenLung
Academic Achievements & Community Involvement
honor Young Investigator Award
International AwardNARSAD Brain and Behavior Research FoundationDetails12/30/2011United States
News
News
- August 21, 2024
Yang Awarded Grant for Study Related to Drug Use and HIV
- April 01, 2011
Advocate for the mentally ill backs young scientists
- March 27, 2011
Ten Yale faculty members are among 214 new NARSAD
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Mailing Address
Psychiatry
300 George St
New Haven, CT 06511-
United States