2024
Nerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits
Kuo S, Lin C, Tsou C, Yeh Y, Yang B, Chen C, Huang C, Huang S. Nerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits. European Archives Of Psychiatry And Clinical Neuroscience 2024, 1-12. PMID: 39311999, DOI: 10.1007/s00406-024-01906-9.Peer-Reviewed Original ResearchTridimensional Personality QuestionnairePersonality traitsHeroin dependenceHarm avoidanceBarratt Impulsiveness Scale version 11Tridimensional Personality Questionnaire scoresTrait of impulsivityAssociated with heroin dependenceChinese versionBIS-11Reward processingPersonality QuestionnaireAssociated with traitsFemale HD patientsNeurotrophic factors nerve growth factorFemale subgroupPotential confounding effectsHD patientsGenetic contributionPersonsTraitsCo-occurrenceGene polymorphismsVersion 11Confounding effectsNeurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampus
2023
F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK
Zhou H, Yang B, Kranzler H, Gelernter J. F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK. European Neuropsychopharmacology 2023, 75: s274. DOI: 10.1016/j.euroneuro.2023.08.480.Peer-Reviewed Original ResearchInverse variance weightingAlcohol useCancer riskOral/pharyngeal cancerOral cancer riskMendelian randomizationMendelian randomization analysisCumulative epidemiological evidenceSpecific cancer typesDevelopment of cancerPharyngeal cancerEsophageal cancerEpidemiological evidenceProblematic alcohol useAlcohol consumptionUnderreported populationCancerCancer typesMR studiesMR-PRESSOAlcohol-related phenotypesDifferent cancersRandomization analysisBreastMR-EggerDifferences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder
He L, Yang B, Ma Y, Wen L, Liu F, Zhang X, Liu T. Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder. Frontiers In Cellular And Infection Microbiology 2023, 13: 1103919. PMID: 36909722, PMCID: PMC9996337, DOI: 10.3389/fcimb.2023.1103919.Peer-Reviewed Original ResearchConceptsMA use disorderClinical featuresGut microbiotaWithdrawal symptomsMA usersEnterotype 2Use disordersGM diversityBody mass indexMethamphetamine use disorderSemi-Structured AssessmentMass indexNeuropsychiatric symptomsHigh incidenceDiagnostic criteriaDifferential microbesDistinct enterotypesDrug dependenceGM differencesSymptomsClinical traitsPerformed network analysisStrong cravingsFecal samplesFurther studies
2021
Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
Ma YJ, Wang YY, Liu MQ, Fang T, Wei ZR, Chen SB, Tan H, Nunez YZ, Zhang XJ, Hao W, Malison RT, Kranzler HR, Gelernter J, Liu TQ, Yang BZ. Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug And Alcohol Dependence 2021, 229: 109047. PMID: 34710713, DOI: 10.1016/j.drugalcdep.2021.109047.Peer-Reviewed Original Research
2020
Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference
Yang C, Fu X, Hao W, Xiang X, Liu T, Yang B, Zhang X. Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference. Addiction Biology 2020, 26: e12975. PMID: 33094505, DOI: 10.1111/adb.12975.Peer-Reviewed Original ResearchConceptsMA use disorderGut microbiota compositionGut dysbiosisUse disordersGut microbiotaCPP scoresMicrobiota compositionHigher CPP scoresSusceptible riskRibosomal RNA sequencingCPP trainingRat modelSame doseDrug effectsPlace preferencePotent stimulantDysbiosisRats' responsesImportant modulatorCumulative evidenceRatsLow CPPMethamphetamineDisordersCPPGABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals
Yang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals. Addictive Behaviors 2020, 114: 106695. PMID: 33153773, PMCID: PMC8299472, DOI: 10.1016/j.addbeh.2020.106695.Peer-Reviewed Original ResearchDiagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version
Yang BZ, Wang LJ, Huang MC, Wang SC, Tsai MC, Huang YC, Nuñez YZ, Ng MH, Kranzler HR, Gelernter J, Chen CK. Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version. Complex Psychiatry 2020, 6: 62-67. PMID: 34882761, PMCID: PMC7923924, DOI: 10.1159/000511606.Peer-Reviewed Original ResearchSD diagnosisSemi-Structured AssessmentTest-retest reliabilityDependence diagnosisDrug dependenceΚ statisticDiagnostic reliabilityStructured Clinical InterviewCohen κ statisticChance-corrected agreementClinician versionSubstance dependence diagnosesNicotine dependencePsychiatric disordersClinical InterviewAlcohol dependenceDSM-IVDiagnosisSubstance useChinese versionOpioidsValid instrumentConcurrent validityKetamineMethamphetamineTubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children
de Araújo CM, Hudziak J, Crocetti D, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Yang BZ, Mostofsky S, Jackowski A, Lee RS, Gelernter J, Kaufman J. Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children. Psychiatry Research Neuroimaging 2020, 298: 111058. PMID: 32120304, PMCID: PMC11079625, DOI: 10.1016/j.pscychresns.2020.111058.Peer-Reviewed Original ResearchConceptsStress-related psychiatric disordersCorpus callosum measuresFractional anisotropyPsychiatric disordersTrauma experiencesWhite matter tractsChild trauma experiencesBrain changesLarger studyRelevant covariatesAtlas-based approachSplenium fractional anisotropyDNA specimensMultiple comparisonsGene methylationDisordersChildrenCurrent study
2019
Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans
Yang BZ, Zhou H, Cheng Z, Kranzler HR, Gelernter J. Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. Scientific Reports 2019, 9: 18070. PMID: 31792237, PMCID: PMC6889277, DOI: 10.1038/s41598-019-53560-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesAnalgesics, OpioidBlack or African AmericanBrainCalcium-Binding ProteinsFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, G-Protein-CoupledReceptors, Kainic AcidSex FactorsWhite PeopleConceptsOpioid dependenceOD riskSex-different effectsSex differencesInferior olivary nucleusDSM-IV diagnosisDimorphic riskSubstantia nigraAA menOlivary nucleusFrontal cortexEuropean-American subjectsADGRV1Further studiesRiskAfrican AmericansGenetic variantsDisease enrichment analysisBrainSex interactionNominal significanceMenFirst studyPutamenLungGenome‐wide scan identifies opioid overdose risk locus close to MCOLN1
Cheng Z, Yang B, Zhou H, Nunez Y, Kranzler HR, Gelernter J. Genome‐wide scan identifies opioid overdose risk locus close to MCOLN1. Addiction Biology 2019, 25: e12811. PMID: 31362332, PMCID: PMC7485539, DOI: 10.1111/adb.12811.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMucolipin-1Expression profilesGenome-wide significant signalsAssociation studiesPost-GWAS analysisWide association studyDrug repositioning analysisCation channel activityFunctional categoriesConnectivity Map databaseDrug targetsRisk genesGenesChannel activityPatatin-like phospholipaseNetwork analysisPNPLA6Significant signalEuropean AmericansF135GENOMEWIDE SEX-BY-SNP INTERACTION SCAN IDENTIFIES ADGRV1 FOR THE SEX DIFFERENCES OF OPIOID DEPENDENCE IN AFRICAN AMERICAN AND SUPPORTING EVIDENCE IN RELATIONS WITH TREATMENT SIDE EFFECTS IN THE ASIAN POPULATION
Yang B, Zhou H, Cheng Z, Liu T, Chung R, Kranzler H, Wang S, Farrer L, Liu Y, Gelernter J. F135GENOMEWIDE SEX-BY-SNP INTERACTION SCAN IDENTIFIES ADGRV1 FOR THE SEX DIFFERENCES OF OPIOID DEPENDENCE IN AFRICAN AMERICAN AND SUPPORTING EVIDENCE IN RELATIONS WITH TREATMENT SIDE EFFECTS IN THE ASIAN POPULATION. European Neuropsychopharmacology 2019, 29: s1183-s1184. DOI: 10.1016/j.euroneuro.2018.08.215.Peer-Reviewed Original ResearchM31 GENOME-WIDE ASSOCIATION STUDY OF COMORBID ALCOHOL DEPENDENCE AND MAJOR DEPRESSION
Zhou H, Polimanti R, Yang B, Wang Q, Han S, Sherva R, Nunez Y, Zhao H, Farrer L, Kranzler H, Gelernter J. M31 GENOME-WIDE ASSOCIATION STUDY OF COMORBID ALCOHOL DEPENDENCE AND MAJOR DEPRESSION. European Neuropsychopharmacology 2019, 29: s971. DOI: 10.1016/j.euroneuro.2017.08.338.Peer-Reviewed Original Research
2018
GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network
Xiang B, Yang B, Zhou H, Kranzler H, Gelernter J. GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 180: 3-11. PMID: 30488612, PMCID: PMC6918694, DOI: 10.1002/ajmg.b.32692.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAllelesBlack or African AmericanComorbidityEthanolFemaleG(M2) Activator ProteinGene FrequencyGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedNicotinePolymorphism, Single NucleotideProtein Interaction MapsRisk FactorsTobacco Use DisorderWhite PeopleConceptsGene subnetworksProtein-protein interaction (PPI) network analysisGenome-wide significant variantsInteraction network analysisGene-set analysisFunctional enrichment analysisSignificant SNPsQuantitative lociNerve growth factor pathwayGene enrichmentEnrichment analysisNetwork analysisGenetic traitsGrowth factor pathwaysRisk genesSignificant variantsGenesStudy of AddictionSNPsFactor pathwayGM2AAmphetamine addictionGenetic riskGWASSubnetworks
2017
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression
Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry 2017, 74: 1234-1241. PMID: 29071344, PMCID: PMC6331050, DOI: 10.1001/jamapsychiatry.2017.3275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanComorbidityDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedMultifactorial InheritanceOrgan SizePutamenSemaphorin-3AUnited StatesWhite PeopleConceptsGenome-wide association studiesGenetic risk variantsNeuropsychiatric traitsAssociation studiesRisk variantsPolygenic risk allelesPolygenic risk scoresGenetic mechanismsGenetic basisAmerican data setMolecular natureTraitsCriterion countsGenetic causePossible genetic causesMD comorbidityRisk allelesComorbid alcohol dependenceGRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers
Yang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.Peer-Reviewed Original Research
2016
Sex‐specific linkage scans in opioid dependence
Yang B, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex‐specific linkage scans in opioid dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 261-268. PMID: 27762075, PMCID: PMC5695218, DOI: 10.1002/ajmg.b.32507.Peer-Reviewed Original ResearchAdultBlack or African AmericanBlack PeopleChromosome MappingCocaine-Related DisordersFemaleGenetic LinkageGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLod ScoreMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideRisk FactorsSex FactorsWhite People
2014
The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
Jensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersCocaine-induced paranoiaAnxiety disorder casesWhole blood cellsPsychiatric disorder riskWarrants further investigationAfrican American subjectsComorbid drugPD casesPsychiatric disordersAlcohol dependenceBrain tissueCocaine useBehavioral effectsBlood cellsClinical potentialGene variantsDisordersDisorder casesSingle nucleotide polymorphismsDisorder riskIndependent samplesPsychiatric phenotypesFurther investigation
2013
Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking
Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen L, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang B, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng Y, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi M, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin M, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking. Genetic Epidemiology 2013, 37: 846-859. PMID: 24186853, PMCID: PMC3947535, DOI: 10.1002/gepi.21760.Peer-Reviewed Original ResearchConceptsGene clusterAssociation signalsEarly smoking behaviourSmoking behaviorCHRNA5/A3/B4 gene clusterNicotinic acetylcholine receptor genesRobust association signalsNeuronal nicotinic acetylcholine receptor geneAcetylcholine receptor genesNicotine dependenceCHRNB4 gene clusterSignificant associationB4 gene clusterDistinct lociLung cancer riskRegular tobacco useAssociation resultsNicotine dependence phenotypesDependence phenotypesReceptor geneCotinine levelsRs1948PhenotypeRegular smokingProtective effect
2012
GABRA2 Genotype, Impulsivity, and Body Mass
Bauer LO, Yang B, Houston RJ, Kranzler HR, Gelernter J. GABRA2 Genotype, Impulsivity, and Body Mass. American Journal On Addictions 2012, 21: 404-410. PMID: 22882390, PMCID: PMC3773931, DOI: 10.1111/j.1521-0391.2012.00252.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttention Deficit Disorder with HyperactivityBody Mass IndexCase-Control StudiesConnecticutFemaleGenotypeHumansImpulsive BehaviorMaleMiddle AgedPolymorphism, Single NucleotidePsychiatric Status Rating ScalesReceptors, GABA-ASex FactorsSubstance Abuse Treatment CentersSubstance-Related DisordersConceptsBody mass indexElevated body mass indexAssociation of BMIGABRA2 genotypeSubstance dependenceAttention-deficit/hyperactivity disorderHigh-calorie foodsPrevious pregnancyMass indexElectroencephalographic featuresRisk factorsChildhood symptomsScale scoreDrug abstinenceCalorie foodsHyperactivity disorderGenetic findingsWomenLonger durationBarratt Impulsiveness ScalePsychological indicatorsGABRA2 variantsSex differencesSecond analysisBody mass