Andrew Prendergast, BA, PhD
Scientific DirectorCards
About
Research
Publications
2023
Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections
Wyart C, Jim K, Prendergast A. Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections. Neuroscience 2023, 525: 47-50. PMID: 37419406, DOI: 10.1016/j.neuroscience.2023.07.008.Peer-Reviewed Original ResearchConceptsSensory cellsNervous systemInternal physiologyPresence of pathogensExternal cuesRelease of compoundsPathogenic bacteriaCentral nervous systemHomeostatic regulationInternal cuesHost defenseNeuronal activationCellsClassical functionsHost responseReceptor propertiesSensory systemsCuesInfectionBacteriaRegulationPhysiologyField of neurosciencePathogensInvasionCSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
Prendergast A, Jim K, Marnas H, Desban L, Quan F, Djenoune L, Laghi V, Hocquemiller A, Lunsford E, Roussel J, Keiser L, Lejeune F, Dhanasekar M, Bardet P, Levraud J, van de Beek D, Vandenbroucke-Grauls C, Wyart C. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 2023, 33: 940-956.e10. PMID: 36791723, DOI: 10.1016/j.cub.2023.01.039.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidSensory neuronsNervous systemStreptococcus pneumoniaeCentral nervous system infectionBlockade of neurotransmissionCentral sensory neuronsNervous system infectionHost survivalPeripheral nervous systemCell-specific ablationEpileptic-like seizuresCSF-contacting neuronsSupernatants of cellsPneumococcal meningitisSystem infectionBitter taste receptorsCSF infectionPneumoniae infectionNeurotropic virusesSpinal cordPathogenic bacteriaPostural controlMeningitis
2022
Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm
Prendergast A, Ziganshin BA, Papanikolaou D, Zafar MA, Nicoli S, Mukherjee S, Elefteriades JA. Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm. Genes 2022, 13: 123. PMID: 35052463, PMCID: PMC8775119, DOI: 10.3390/genes13010123.Peer-Reviewed Original ResearchConceptsAortic aneurysmSkeletal abnormalitiesThoracic aortic aneurysmWhole-exome sequencingDirect microscopic assessmentSilico genetic analysisVisualized abnormalitiesTAA patientsClinical managementGeneral populationClinical practiceRoutine assessmentClinical testingCell countEvidence-based decisionsUnknown significanceUncertain significanceExperimental modelPilot studyExome sequencingAbnormalitiesMicroscopic assessmentPatientsPositive controlAneurysms
2021
PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nature Medicine 2021, 27: 2165-2175. PMID: 34887573, PMCID: PMC8768030, DOI: 10.1038/s41591-021-01572-7.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPeptidyl-prolyl cis-transPathogenesis of IAContribution of variantsCommon genetic variantsVertebrate modelDeleterious mutationsWnt activatorAssociation studiesWhole-exome sequencingSignificant enrichmentGenetic variantsWntAngiogenesis regulatorsMutationsGene mutationsBrain angiogenesisIntracranial aneurysm ruptureJMJD6AngiogenesisCerebrovascular morphologyCerebrovascular integrityIntracerebral hemorrhageAneurysm ruptureVariants
2020
Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture
Oldfield C, Grossrubatscher I, Chávez M, Hoagland A, Huth A, Carroll E, Prendergast A, Qu T, Gallant J, Wyart C, Isacoff E. Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture. ELife 2020, 9: e56619. PMID: 32985972, PMCID: PMC7561350, DOI: 10.7554/elife.56619.Peer-Reviewed Original Research
2019
Glia: A Gate Controlling Animal Behavior?
Wyart C, Prendergast A. Glia: A Gate Controlling Animal Behavior? Current Biology 2019, 29: r847-r850. PMID: 31505186, DOI: 10.1016/j.cub.2019.07.058.Peer-Reviewed Original ResearchRegulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons
Desban L, Prendergast A, Roussel J, Rosello M, Geny D, Wyart C, Bardet PL. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLOS Biology 2019, 17: e3000235. PMID: 31002663, PMCID: PMC6493769, DOI: 10.1371/journal.pbio.3000235.Peer-Reviewed Original ResearchConceptsRing of actinApical junctional complexApical extensionSensory cellsApical actin ringSensory cell typesInner ear sensory cellsTime-lapse imagingVivo time-lapse imagingZebrafish embryosMorphogenesisActin ringsCell typesHair bundlesMechanosensory responsesProtrusion elongationJunctional complexesActinTail bendingMolecular factorsCerebrospinal fluid-contacting neuronsApical attachmentCritical roleOsmolarity changesApical processes
2018
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del’Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9: 3804. PMID: 30228263, PMCID: PMC6143598, DOI: 10.1038/s41467-018-06225-x.Peer-Reviewed Original ResearchConceptsCentral canalCSF-cNsSpontaneous activityCSF flowCerebrospinal fluid-contacting neuronsSpine curvatureCSF-contacting neuronsCerebrospinal fluid flowSpinal cordIdiopathic scoliosisSingle-channel openingsCalcium activityPKD2L1 channelPKD2L1Mechanosensory cellsNeuronsCanalChannel openingMechanoceptionKyphosisCilia motilityCord
2017
Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae.
Knafo S, Prendergast A, Thouvenin O, Figueiredo SN, Wyart C. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. Bio-protocol 2017, 7: e2550. PMID: 29130058, PMCID: PMC5681248, DOI: 10.21769/bioprotoc.2550.Peer-Reviewed Original ResearchMechanosensory neurons control the timing of spinal microcircuit selection during locomotion
Knafo S, Fidelin K, Prendergast A, Tseng PB, Parrin A, Dickey C, Böhm UL, Figueiredo SN, Thouvenin O, Pascal-Moussellard H, Wyart C. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. ELife 2017, 6: e25260. PMID: 28623664, PMCID: PMC5499942, DOI: 10.7554/elife.25260.Peer-Reviewed Original ResearchConceptsSpinal cordMechanosensory neuronsRohon-Beard neuronsMonosynaptic inputSpinal circuitsMotor poolsCordNeuronsV2a interneuronsVertebrate spinal cordMechanosensory feedbackNumerous physiological studiesSimple locomotionPhysiological studiesActive locomotionLocomotor speedEscape responseInterneuronsZebrafish larvae
News
News
- July 11, 2024
Protein Detects and Responds to Changes in Blood Flow
- December 08, 2021
Yale researchers find early developmental gene can cause deadly aneurysms
- January 29, 2020
Dean's Workshop: "Modeling Human Disease Using the Yale Zebrafish Phenotyping Core" on Feb. 28
- September 16, 2019
2019 Department of Internal Medicine Faculty Appointments and Promotions
Get In Touch
Contacts
Academic Office Number
Mailing Address
Comparative Medicine
300 George St., Room 0752
New Haven, CT 06511
United States
Locations
Yale Zebrafish Phenotyping Core
Academic Office
Sterling Hall of Medicine
333 Cedar Street, Wing I, Fl G, Ste 0, Rm 43
New Haven, CT 06510
Business Office
203.737.1368