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Biostatistics & Study Design

Biostatistical and epidemiological support for clinical and translational research is provided through the Yale Center for Analytical Sciences (YCAS).

Supported by YCCI, the School of Public Health, and Yale Cancer Center, YCAS expertise and resources are available to all departments and schools across the medical campus.

The YCAS team can aid researchers in a wide variety of ways, from pre-design advice to manuscript preparation and revision. They will ensure that research is being conducted using sound analytical principles and practice by helping to develop testable hypotheses ensuring adequate sample size as well as appropriate analytical methods and proper interpretation of analyses. YCAS faculty and staff interact with clinical investigators in the following ways:

  • Collaboration
  • Short-term consultation
  • Data analysis
  • Education and training

Biostatistics Leadership

  • Professor of Emergency Medicine and of Biostatistics and of Medicine (Endocrinology); Deputy Director, Yale Center for Analytical Sciences; Deputy Director, Yale Data Coordinating Center

    Jim is a Professor in the Department of Emergency Medicine at YMS. As a biostatistician at Yale since 2002 he has co-authored over 200 peer-reviewed articles with a diverse group of Yale investigators. Dr. Dziura also serves as the Deputy Director of both the Yale Center for Analytical Sciences (YCAS) and the Yale Data Coordinating Center (YDCC) in the Yale School of Public Health. He has been active in training young investigators, both individually (as a mentor and statistical resource for K-awardees, post-doctoral fellows, residents and Master’s students) and in the classroom (where he has developed a graduate-level course and several workshops on biostatistics in clinical research). His primary research interests are in the coordination of multicenter clinical trials. Over the past ten years he has overseen data coordinating and biostatistical efforts for several trials. Notably, he served as the PI of the data coordinating center for the RUPP Autism Network study of Guanfacine for the treatment of hyperactivity. He is the Director of the Data Coordinating Center for the Autism Biomarkers Consortium for Clinical Trials (ABC-CT), a multicenter longitudinal study developing reproducible experimental biomarkers (e.g. from EEG, eye tracking) for use as stratification factors and outcomes in clinical trials.He is a senior biostatistician (and unblinded statistician for the DSMB) for the Data Coordinating Center of a large pragmatic cluster-randomized trial for the prevention of serious fall injuries (STRIDE) in 6,000 older persons from 86 health care practices.
  • Professor Emeritus of Biostatistics and Senior Research Scientist of Biostatistics; Director Yale Data Coordinating Center

    Peter is professor of biostatistics at YSPH and director of the Yale Center for Analytical Sciences (YCAS) and the Yale Data Coordinating Center. Dr. Peduzzi has nearly 40 years’ experience in the design, conduct and analysis of clinical trials with a particular focus on pragmatic trials. He is the PI of several data coordinating centers funded by NIH and PCORI. Before coming to Yale he was the Director of the Department of Veterans Affairs (VA) Cooperative Studies Program Coordinating Center in West Haven, Connecticut, which conducts multi-center, multi-national clinical trials and epidemiologic studies. He still maintains an affiliation with this center. His primary research interests have focused on the efficient design and analysis of clinical trials, with a recent focus on clustered randomized trials.