Shangqin Guo, PhD
Associate Professor in Cell BiologyDownloadHi-Res Photo
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Cell Biology
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Associate Professor in Cell Biology
Appointments
Cell Biology
Associate Professor TenurePrimary
Other Departments & Organizations
- Cell Biology
- Genomics, Genetics, and Epigenetics
- Molecular Cell Biology, Genetics and Development
- Program in Translational Biomedicine (PTB)
- Status of Women in Medicine Committee (SWIM)
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
- YCCEH
Education & Training
- PhD
- Boston University (2005)
Research
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Overview
Medical Research Interests
Cell Biology; Cellular Reprogramming; Hematopoietic Stem Cells; Leukemia, Experimental
ORCID
0000-0003-1157-0423- View Lab Website
Guo lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Shangqin Guo's published research.
Publications Timeline
A big-picture view of Shangqin Guo's research output by year.
Research Interests
Research topics Shangqin Guo is interested in exploring.
Jun Lu, PhD
Cynthia Megyola
Diane Krause, MD, PhD
Mei Zhong, PhD
In-Hyun Park, PhD
Patrick Gallagher, MD, BS
40Publications
2,739Citations
Cellular Reprogramming
Hematopoietic Stem Cells
Publications
2025
Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors
Karatepe K, de Faria B, Zhang J, Chen X, Pinto H, Fyodorov D, Sefik E, Willcockson M, Flavell R, Skoultchi A, Guo S. Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509412122. PMID: 41118213, PMCID: PMC12582276, DOI: 10.1073/pnas.2509412122.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMyeloid-biased differentiationGenomic regionsChromatin accessibilityLinker histonesLymphoid fateHematopoietic stemResponse to interferon-alphaNucleosome organizationFate choiceGene expressionChromatinAspartyl protease inhibitorMarker genesMolecular mechanism(sMyeloid biasFate biasLymphoid potentialInterferon-alphaProgenitor cellsHSPCsHistoneMolecular scenarioGenesAspartylProtease inhibitorsMolecular basis of cell fate plasticity — insights from the privileged cells
Scalf S, Wu Q, Guo S. Molecular basis of cell fate plasticity — insights from the privileged cells. Current Opinion In Genetics & Development 2025, 93: 102354. PMID: 40327951, PMCID: PMC12277062, DOI: 10.1016/j.gde.2025.102354.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitations
2023
Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability
Zhang J, Wu Q, Hu X, Wang Y, Lu J, Chakraborty R, Martin K, Guo S. Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability. Stem Cells 2023, 41: 907-915. PMID: 37386941, PMCID: PMC11009695, DOI: 10.1093/stmcls/sxad051.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMouse pluripotent stem cellsSerum response factorPluripotent stem cellsCell fate stabilityRole of SRFGene expression noiseHeterogeneous gene expressionResponse factorStem cellsNaïve pluripotencyCell state heterogeneityLineage primingExpression noiseActin dynamicsCellular statesPluripotent cellsSRF functionCell statesMechanical signalingGene expressionFunctional modulationCentral mediatorSerum-containing culturesState heterogeneityCellsCell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
Feng X, Sun R, Lee M, Chen X, Guo S, Geng H, Müschen M, Choi J, Pereira J. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. ELife 2023, 12: e83533. PMID: 36912771, PMCID: PMC10042536, DOI: 10.7554/elife.83533.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMesenchymal stem cellsLymphotoxin beta receptorLeukemic cellsBeta receptorsLeukemic cell growthBone marrow microenvironmentStem cellsTransplant recipientsAML cellsMyeloblastic leukemiaMouse modelBone marrowLeukemia growthLymphotoxin α1β2Marrow microenvironmentPharmacological disruptionLymphopoiesisReceptorsHematopoietic outputMolecular mechanismsErythropoiesisDNA damage response pathwayCell growthCellsPhysiological mechanisms
2022
Incorporating signaling dynamics into fate decision
Guo S. Incorporating signaling dynamics into fate decision. Blood 2022, 140: 79-80. PMID: 35834282, PMCID: PMC9283969, DOI: 10.1182/blood.2022016420.Commentaries, Editorials and LettersAltmetricIntegrating mechanical signals into cellular identity
Carley E, King MC, Guo S. Integrating mechanical signals into cellular identity. Trends In Cell Biology 2022, 32: 669-680. PMID: 35337714, PMCID: PMC9288541, DOI: 10.1016/j.tcb.2022.02.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsDistinct gene expression programsComplex cellular programsGene expression programsLineage-committed cellsPluripotent stem cellsMulticellular organismsExpression programsCellular identityCellular programsMechanical signalsCell typesStem cellsMechanical inputCellsBiochemical inputsFunction correlationGenomeCytoskeletonOrganismsNumber of studiesImportant determinantComplex axisIdentityLarge arrayVivo
2021
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Maxwell Scalf S, Eastman AE, Chen JJ, Zhu LJ, Heuberger JAAC, Guo S, Koury MJ, Nordsborg NB, Socolovsky M. EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications 2021, 12: 7334. PMID: 34921133, PMCID: PMC8683474, DOI: 10.1038/s41467-021-27562-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAnimalsAntigens, CDbcl-X ProteinCD4 AntigensCell CycleCell DifferentiationCell NucleusCell SizeCell SurvivalCyclin-Dependent Kinase Inhibitor p27Embryo, MammalianErythroblastsErythrocytesErythropoiesisErythropoietinFemaleFetusHealthy VolunteersHumansIronLiverMaleMice, Inbred C57BLModels, BiologicalProtein Serine-Threonine KinasesReceptors, ErythropoietinReceptors, TransferrinReticulocytesSignal TransductionConceptsCell size regulationCell sizeSequential cell divisionsEpoR functionErythroblast survivalMouse erythroblastsCell divisionSize regulationHuman erythropoiesisErythropoietin receptorCell cycleEpoRHypoxic stressRed cell sizeHigh erythropoietinLarger red cellsWild-type miceCyclingErythroblastsRegulationHigher EPO levelsMiceRed cellsSurvivalErythropoiesis
2020
Reprogramming progressive cells display low CAG promoter activity
Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park I, Guo S. Reprogramming progressive cells display low CAG promoter activity. Stem Cells 2020, 39: 43-54. PMID: 33075202, PMCID: PMC7821215, DOI: 10.1002/stem.3295.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsThe palette of techniques for cell cycle analysis
Eastman AE, Guo S. The palette of techniques for cell cycle analysis. FEBS Letters 2020, 594: 2084-2098. PMID: 32441778, PMCID: PMC9261528, DOI: 10.1002/1873-3468.13842.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsCell cycleCell cycle analysisCell fate specificationCell division cycleCell cycle speedSingle-cell eraSingle-cell resolutionCell cycle progressionCell cycle dynamicsMulticellular organismsFate specificationCell cycle heterogeneityGenomic fidelityDivision cycleBiochemical machineryTissue homeostasisCycle progressionCellular growthCell cycle measurementsCycle analysisPalette of techniquesGenerational periodCycle dynamicsCentral roleCell numberResolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter
Eastman AE, Chen X, Hu X, Hartman AA, Morales A, Yang C, Lu J, Kueh HY, Guo S. Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter. Cell Reports 2020, 31: 107804. PMID: 32579930, PMCID: PMC7418154, DOI: 10.1016/j.celrep.2020.107804.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFluorescent reportersLive-cell fluorescent reporterCell cycle speedFluorescent timer proteinsCell proliferationCell cycle dynamicsRed fluorescent proteinFaster cycling cellsFate transitionsFusion reporterActive lociTimer proteinFluorescent proteinLength heterogeneityComplex tissuesHematopoietic cellsCycling cellsReporterFluorescence ratioCycle dynamicsProteinFunctional heterogeneityMouse strainsSolid tissuesCycle speed
Academic Achievements & Community Involvement
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Honors
honor Director's New Innovator Award (DP2)
10/01/2016National AwardDetailsUnited Stateshonor Charles H. Hood Foundation Child Health Research Award
03/01/2016Regional AwardDetailsUnited Stateshonor Gilead Sciences Research Scholar in Hematology/oncology
12/05/2015International AwardDetailsUnited Stateshonor Yale Center for Clinical Investigation Scholar
09/01/2014Yale University AwardDetailsUnited States
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- Growing colonies during Yamanaka reprogramming captured by live-cell imaging. Green color indicates pluripotency (Oct4:GFP). Red color indicates G1 cell cycle phase (FUCCI).
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Cell Biology
10 Amistad St.
New Haven, CT 06520-8005
United States