Mei Zhong, PhD
Cards
About
Research
Publications
Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment
Lin H, Zhou J, Ding T, Zhu Y, Wang L, Zhong T, Wang X. Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment. European Journal Of Medical Research 2024, 29: 350. PMID: 38943222, PMCID: PMC11212438, DOI: 10.1186/s40001-024-01937-x.Peer-Reviewed Original ResearchConceptsPotential of extracellular vesiclesExtracellular vesiclesTumor growthDissemination of primary tumorsCancer treatmentBiological characteristics of extracellular vesiclesTherapeutic potential of extracellular vesiclesRegulate tumor growthEffective cancer treatmentCharacteristics of extracellular vesiclesCytoplasmic proteinsEngineered extracellular vesiclesPrimary tumorComplex diseasesDistant organsCancer therapyCancer developmentCell differentiationImmune responseInfluence cancerCancerTherapeutic potentialIntercellular communicationExcessive proliferationOncogenic factorResearch progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases
Zhu Y, Wang F, Xia Y, Wang L, Lin H, Zhong T, Wang X. Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases. Reviews In The Neurosciences 2024, 0 PMID: 38889403, DOI: 10.1515/revneuro-2024-0043.Peer-Reviewed Original ResearchAstrocyte-derived extracellular vesiclesProteins associated with neurodegenerative diseasesTreatment of neurodegenerative diseasesExtracellular vesiclesNeurodegenerative disordersNeurodegenerative diseasesHuntington's diseaseAggregation of pathogenic proteinsAlzheimer's diseaseTransfer of biomoleculesAmyotrophic lateral sclerosisCell to cellDiverse target cellsIntercellular communicationPathogenic proteinsContext of neurological disordersIntercellular transportAberrant accumulationPotential dual roleCentral nervous systemDevelopment of neurological disordersVesiclesProteinLateral sclerosisNeurological disordersRole of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
Huang D, Shen H, Xie F, Hu D, Jin Q, Hu Y, Zhong T. Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues. Journal Of Biological Engineering 2024, 18: 36. PMID: 38845032, PMCID: PMC11155050, DOI: 10.1186/s13036-024-00431-6.Peer-Reviewed Original ResearchMesenchymal stem cellsMSC-ExosTissue regenerationMesenchymal stem cell-derived exosomesStem cell-derived exosomesImmune effector cellsCell-derived exosomesIschemic heart diseaseMSC-derived exosomesEffector cellsLung injuryArticular cartilageTissue applicationsLiver fibrosisInflammatory diseasesImmune responseHeart diseaseAnti-inflammatory compoundsStem cellsIntercellular communicationClinical applicationDiseaseExosomesTissueLiverExtracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis
Ma Z, Sun Y, Yu Y, Xiao W, Xiao Z, Zhong T, Xiang X, Li Z. Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis. Cell Communication And Signaling 2024, 22: 295. PMID: 38802814, PMCID: PMC11131254, DOI: 10.1186/s12964-024-01669-9.Peer-Reviewed Original ResearchConceptsProteomic analysisExtracellular vesiclesSignaling pathwayCRC cell linesFlow cytometric analysisMacrophage efferocytosisCRC cellsClear apoptotic cellsCell linesMass spectrometry-based proteomic analysisCRISPR-Cas9 gene editing systemCytometric analysisInvolvement of extracellular vesiclesEfferocytosis in vitroCancer Genome AtlasGene editing systemTumor microenvironmentCRISPR-Cas9Apoptotic cellsCell surfacePromotion of drug resistanceMFGE8Genome AtlasProtein moleculesEditing systemMicrobial extracellular vesicles contribute to antimicrobial resistance
Jiang B, Lai Y, Xiao W, Zhong T, Liu F, Gong J, Huang J. Microbial extracellular vesicles contribute to antimicrobial resistance. PLOS Pathogens 2024, 20: e1012143. PMID: 38696356, PMCID: PMC11065233, DOI: 10.1371/journal.ppat.1012143.Peer-Reviewed Original ResearchConceptsMicrobial extracellular vesiclesAntimicrobial resistanceExtracellular vesiclesBacterial extracellular vesiclesDrug-resistant microbesAntimicrobial resistance crisisParasite extracellular vesiclesResistance crisisGlobal antimicrobial resistance crisisAntimicrobial approachesAntimicrobial therapyVesiclesFungalMicrobesResistanceTumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives
Wang L, Wang W, Hu D, Liang Y, Liu Z, Zhong T, Wang X. Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives. Frontiers In Immunology 2024, 15: 1346587. PMID: 38690261, PMCID: PMC11058222, DOI: 10.3389/fimmu.2024.1346587.Peer-Reviewed Original ResearchConceptsTumor-derived extracellular vesiclesTumor developmentBreast carcinomaLung carcinomaExtracellular vesiclesM2 phenotypeMacrophage polarizationM2 polarizationPromote tumor developmentStimulate macrophage polarizationAnti-tumor activityM2 to M1 macrophagesAnti-inflammatory effectsInduced M2 polarizationPancreatic carcinomaPro-tumorColorectal carcinomaTumor progressionHepatocellular carcinomaCarcinomaColorectal cancerRegulating tumor developmentCell ratioM1 macrophagesPromote M2 polarizationResearch progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases
Wang L, Fang X, Ling B, Wang F, Xia Y, Zhang W, Zhong T, Wang X. Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases. Frontiers In Cellular Neuroscience 2024, 18: 1359453. PMID: 38515787, PMCID: PMC10955106, DOI: 10.3389/fncel.2024.1359453.Peer-Reviewed Original ResearchNeurodegenerative diseasesHuntington's diseaseAlzheimer's diseaseAmyotrophic lateral sclerosisSignaling networksDisease-related researchTreatment of neurodegenerative diseasesCell deathPathogenic cascadeIron-dependentNeurodegenerative disordersBreakdown of cellsNeurodegenerative conditionsFerroptosisLateral sclerosisNeuronal lossParkinson's diseaseCellsHuntingtonTherapeutic approachesAlzheimerLipid peroxidationDiseaseMechanismLipidOxymatrine Inhibition of Hepatitis B Virus Replication Through ERK1/2 Pathway and HNF1α and HNF4α Block <em>in vitro</em>.
Wang F, Wang X, Ling B, Lu H, Huang J, Zhong T. Oxymatrine Inhibition of Hepatitis B Virus Replication Through ERK1/2 Pathway and HNF1α and HNF4α Block in vitro. Journal Of College Of Physicians And Surgeons Pakistan 2024, 34: 329-335. PMID: 38462870, DOI: 10.29271/jcpsp.2024.03.329.Peer-Reviewed Original ResearchConceptsTranscription factor HNF1AHepatitis B virusDNA copy numberHNF4A expressionCell-free culture mediumInhibition of hepatitis B virus replicationProtein translationRNA gene expressionDNA replicationHepatitis B virus DNA replicationHepatitis B virus DNAPhosphorylation of ERK1/2Copy numberGene transcriptionReal-time PCRERK1/2 protein expressionB virus replicationGene expressionReplication of hepatitis B virusEnzyme-linked immunosorbent assay kitHepatitis B virus replicationCell-based modelsSignaling factorsHBV DNA copy numberMolecular mechanismsGlycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis
Guo Q, Zhao M, Wang Q, Lu T, Luo P, Chen L, Xia F, Pang H, Shen S, Cheng G, Dai C, Meng Y, Zhong T, Qiu C, Wang J. Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis. Biomedicine & Pharmacotherapy 2024, 173: 116304. PMID: 38401519, DOI: 10.1016/j.biopha.2024.116304.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerMitochondrial apoptosisActivity-based protein profilingLung cancerTreatment of non-small cell lung cancerGlycyrrhetinic acidInhibit non-small cell lung cancerCombination of histopathologyCaspase-3Proteomic validationTarget of GAIn vivo resultsProtein profilesPeroxiredoxin 6Clinical applicationIn vitroApoptosisPotential targetCancerPrdx6Application of GAPromoterResearch progress of CTC, ctDNA, and EVs in cancer liquid biopsy
Wang X, Wang L, Lin H, Zhu Y, Huang D, Lai M, Xi X, Huang J, Zhang W, Zhong T. Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy. Frontiers In Oncology 2024, 14: 1303335. PMID: 38333685, PMCID: PMC10850354, DOI: 10.3389/fonc.2024.1303335.Peer-Reviewed Original ResearchCirculating tumor DNAExtracellular vehiclesLiquid biopsyTumor-derived materialCirculating cancer cellsLiquid biopsy biomarkersOriginal tumorTumor DNATumor cellsClinical trialsPrognosis of neoplastic diseasesCancer cellsPrognosis predictionTherapeutic monitoringClinical utilityNeoplastic diseaseBiopsyTumorPrecision medicinePrognosisCancer diagnosisBiomarkersCancerDiagnosisCells