John Lewin, MD
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
2015
Contrast-enhanced tomosynthesis: The best of both worlds or more of the same?
Chou C, Lewin J, Pan H. Contrast-enhanced tomosynthesis: The best of both worlds or more of the same? European Journal Of Radiology 2015, 85: 509. PMID: 26724999, DOI: 10.1016/j.ejrad.2015.11.033.Peer-Reviewed Original ResearchClinical evaluation of contrast-enhanced digital mammography and contrast enhanced tomosynthesis—Comparison to contrast-enhanced breast MRI
Chou C, Lewin J, Chiang C, Hung B, Yang T, Huang J, Liao J, Pan H. Clinical evaluation of contrast-enhanced digital mammography and contrast enhanced tomosynthesis—Comparison to contrast-enhanced breast MRI. European Journal Of Radiology 2015, 84: 2501-2508. PMID: 26456307, DOI: 10.1016/j.ejrad.2015.09.019.Peer-Reviewed Original ResearchConceptsContrast-enhanced digital mammographyDCE-MRIBreast MRIDigital mammographyBI-RADSNon-target breastInstitutional review board approvalBI-RADS 4Contrast-enhanced breast MRIReview board approvalConventional digital mammographyBI-RADS categoryCranio-caudal viewContrast agent injectionAbnormal mammographyBenign lesionsMalignant lesionsNo significant differenceBoard approvalDiagnostic accuracyMediolateral-oblique viewClinical evaluationDynamic contrastAgent injectionLesions
2011
Differential expression of prognostic biomarkers between interval and screen-detected breast cancers: does age or family history matter?
Lowery J, Byers T, Kittelson J, Hokanson J, Mouchawar J, Lewin J, Merrick D, Hines L, Singh M. Differential expression of prognostic biomarkers between interval and screen-detected breast cancers: does age or family history matter? Breast Cancer Research And Treatment 2011, 129: 211-219. PMID: 21431872, PMCID: PMC4675131, DOI: 10.1007/s10549-011-1448-8.Peer-Reviewed Original ResearchConceptsScreen-detected cancersScreen-detected breast cancerInterval cancersBreast cancerPrognostic biomarkerTriple negative statusInterval breast cancersScreen-detected tumorsFamilial riskFisher's exact testTissue micro arrayLobular histologyProgesterone receptorCancer Genetics NetworkExact testNegative statusOverexpress EGFRDifferential expressionCompare protein expressionImmuno-stainingProtein expressionCancerEGFROlder womenTherapeutic target
2010
Complementary approaches to assessing risk factors for interval breast cancer
Lowery J, Byers T, Hokanson J, Kittelson J, Lewin J, Risendal B, Singh M, Mouchawar J. Complementary approaches to assessing risk factors for interval breast cancer. Cancer Causes & Control 2010, 22: 23-31. PMID: 20978835, DOI: 10.1007/s10552-010-9663-x.Peer-Reviewed Original ResearchConceptsInterval breast cancersInterval cancersDense breastsRisk of interval cancerFamily historyBreast cancerScreen-detected cancersRisk factorsMammography programsScreened womenBreast densityHormone useIntensive screeningLogistic regressionNegative screeningYounger ageIndependent effectsWomenBreastDisproportionate numberReduced occurrenceCancerRiskScreeningIncidence
2009
Bias in trials comparing paired continuous tests can cause researchers to choose the wrong screening modality
Glueck D, Lamb M, O'Donnell C, Ringham B, Brinton J, Muller K, Lewin J, Alonzo T, Pisano E. Bias in trials comparing paired continuous tests can cause researchers to choose the wrong screening modality. BMC Medical Research Methodology 2009, 9: 4. PMID: 19154609, PMCID: PMC2657218, DOI: 10.1186/1471-2288-9-4.Peer-Reviewed Original Research
2007
Two-Modality Mammography May Confer an Advantage Over Either Full-Field Digital Mammography or Screen-Film Mammography
Glueck D, Lamb M, Lewin J, Pisano E. Two-Modality Mammography May Confer an Advantage Over Either Full-Field Digital Mammography or Screen-Film Mammography. Academic Radiology 2007, 14: 670-676. PMID: 17502256, PMCID: PMC1975808, DOI: 10.1016/j.acra.2007.02.011.Peer-Reviewed Original ResearchConceptsCancer detection rateReceiver operating characteristicArea under the curveFull-field digital mammographyScreen-film mammographyDigital mammographyMcNemar testReceiver operating characteristic curveProportion of cancersDetection of breast cancerDetection rateBreast cancerFilm mammographyCancerNonparametric testsMammographyAlpha levelCombined testScreen-filmMammograms
Clinical Trials
Current Trials
Prospective, Multicenter Confirmatory Clinical Evaluation of Novilase® Interstitial Laser Therapy for the Focal Destruction of Malignant Breast Tumors ≤15 mm (BR-003)
HIC ID2000032829RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsGenderFemaleAge18+ yearsI-SPY 2 Trial (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging And moLecular Analysis 2)
HIC ID2000020575RoleSub InvestigatorPrimary Completion Date12/01/2030Recruiting Participants
Academic Achievements & Community Involvement
Clinical Care
Overview
John Lewin, MD, is a specialist in breast cancer radiotherapy. He provides comprehensive care through breast imaging, including mammography, which helps in the early detection and management of breast cancer.
As an associate professor of radiology and biomedical imaging at Yale School of Medicine, Dr. Lewin is involved in research that aims to improve breast cancer screening and diagnosis. His notable research includes pioneering the first clinical trial of digital mammography and demonstrating dual-energy contrast-enhanced mammography.
Dr. Lewin completed his medical training at Harvard Medical School and pursued residency and fellowship in breast imaging at the University of Colorado.
Clinical Specialties
Breast Cancer Radiotherapy
Fact Sheets
Breast Cancer
Learn More on Yale MedicineCancer
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Board Certifications
Diagnostic Radiology
- Certification Organization
- AB of Radiology
- Original Certification Date
- 1995
Yale Medicine News
News
News
- May 05, 2025
Older Women May Benefit From Regular Mammograms
- September 06, 2024Source: Wall Street Journal
Why a Mammogram Isn’t Always Enough to Rule Out Cancer
- June 11, 2024Source: Everyday Health
3D vs. 2D Mammograms: What You Need to Know
- April 08, 2024Source: The New York Times
Is That A.I. Mammogram Worth the Cost?
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